메뉴 건너뛰기




Volumn 11, Issue 4, 2009, Pages 492-500

The effects of punctured nucleus pulposus on lumbar radicular pain in rats: A behavioral and immunohistochemical study - Laboratory investigation

Author keywords

Animal model; Intervertebral disc degeneration; Radicular pain; Rat; Tumor necrosis factor

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

EID: 70349645330     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2009.4.SPINE08744     Document Type: Article
Times cited : (19)

References (47)
  • 1
    • 33747355707 scopus 로고    scopus 로고
    • What is intervertebral disc degeneration, and what causes it?
    • DOI 10.1097/01.brs.0000231761.73859.2c, PII 0000763220060815000024
    • Adams MA, Roughley PJ: What is intervertebral disc degeneration, and what causes it? Spine 31:2151-2161, 2006 (Pubitemid 44246394)
    • (2006) Spine , vol.31 , Issue.18 , pp. 2151-2161
    • Adams, M.A.1    Roughley, P.J.2
  • 2
    • 33645575176 scopus 로고    scopus 로고
    • Relevance of in vitro and in vivo models for intervertebral disc degeneration
    • An HS, Masuda K: Relevance of in vitro and in vivo models for intervertebral disc degeneration. J Bone Joint Surg Am 88 (Suppl 2):88-94, 2006
    • (2006) J Bone Joint Surg Am , vol.88 , Issue.SUPPL. 2 , pp. 88-94
    • An, H.S.1    Masuda, K.2
  • 4
    • 0033554190 scopus 로고    scopus 로고
    • Epidemiological features of chronic low-back pain
    • DOI 10.1016/S0140-6736(99)01312-4
    • Andersson GB: Epidemiological features of chronic low back pain. Lancet 354:581-585, 1999 (Pubitemid 29381383)
    • (1999) Lancet , vol.354 , Issue.9178 , pp. 581-585
    • Andersson, G.B.J.1
  • 5
    • 0036894572 scopus 로고    scopus 로고
    • Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science
    • Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG: Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 27: 2631-2644, 2002
    • (2002) Spine , vol.27 , pp. 2631-2644
    • Boos, N.1    Weissbach, S.2    Rohrbach, H.3    Weiler, C.4    Spratt, K.F.5    Nerlich, A.G.6
  • 6
    • 0029008944 scopus 로고
    • Aging and degeneration of the human intervertebral disc
    • Buckwalter JA: Aging and degeneration of the human intervertebral disc. Spine 20:1307-1314, 1995
    • (1995) Spine , vol.20 , pp. 1307-1314
    • Buckwalter, J.A.1
  • 9
    • 0028814665 scopus 로고
    • Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion
    • Chatani K, Kawakami M, Weinstein JN, Meller ST, Gebhart GF: Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion. Spine 20:277-289, 1995
    • (1995) Spine , vol.20 , pp. 277-289
    • Chatani, K.1    Kawakami, M.2    Weinstein, J.N.3    Meller, S.T.4    Gebhart, G.F.5
  • 10
    • 36148987305 scopus 로고    scopus 로고
    • Biological and mechanical consequences of transient intervertebral disc bending
    • Court C, Chin JR, Liebenberg E, Colliou OK, Lotz JC: Biological and mechanical consequences of transient intervertebral disc bending. Eur Spine J 16:1899-1906, 2007
    • (2007) Eur Spine J , vol.16 , pp. 1899-1906
    • Court, C.1    Chin, J.R.2    Liebenberg, E.3    Colliou, O.K.4    Lotz, J.C.5
  • 12
    • 60549106892 scopus 로고    scopus 로고
    • A simple disc degeneration model induced by percutaneous needle puncture in the rat tail
    • Han B, Zhu K, Li FC, Xiao YX, Feng J, Shi ZL, et al: A simple disc degeneration model induced by percutaneous needle puncture in the rat tail. Spine 33:1925-1934, 2008
    • (2008) Spine , vol.33 , pp. 1925-1934
    • Han, B.1    Zhu, K.2    Li, F.C.3    Xiao, Y.X.4    Feng, J.5    Shi, Z.L.6
  • 13
    • 0141738716 scopus 로고    scopus 로고
    • Chronic inflammation and compression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats
    • Hou SX, Tang JG, Chen HS, Chen J: Chronic inflammation and compression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats. Pain 105: 255-264, 2003
    • (2003) Pain , vol.105 , pp. 255-264
    • Hou, S.X.1    Tang, J.G.2    Chen, H.S.3    Chen, J.4
  • 14
    • 0033562764 scopus 로고    scopus 로고
    • Compression-induced changes in intervertebral disc properties in a rat tail model
    • Iatridis JC, Mente PL, Stokes IA, Aronsson DD, Alini M: Compression-induced changes in intervertebral disc properties in a rat tail model. Spine 24:996-1002, 1999
    • (1999) Spine , vol.24 , pp. 996-1002
    • Iatridis, J.C.1    Mente, P.L.2    Stokes, I.A.3    Aronsson, D.D.4    Alini, M.5
  • 15
    • 0034407331 scopus 로고    scopus 로고
    • 2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats
    • Igarashi T, Kikuchi S, Shubayev V, Myers RR: 2000 Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 25:2975-2980, 2000
    • (2000) Spine , vol.25 , pp. 2975-2980
    • Igarashi, T.1    Kikuchi, S.2    Shubayev, V.3    Myers, R.R.4
  • 16
    • 49149120060 scopus 로고    scopus 로고
    • Role of the tumor necrosis factor-alpha, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model
    • Iwabuchi S, Ito M, Chikanishi T, Azuma Y, Haro H: Role of the tumor necrosis factor-alpha, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model. J Orthop Res 26: 1274-1278, 2008
    • (2008) J Orthop Res , vol.26 , pp. 1274-1278
    • Iwabuchi, S.1    Ito, M.2    Chikanishi, T.3    Azuma, Y.4    Haro, H.5
  • 17
    • 33645556769 scopus 로고    scopus 로고
    • Lumbar disc disorders and low-back pain: Socioeconomic factors and consequences
    • Katz JN: Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. J Bone Joint Surg Am 88 (Suppl 2):21-24, 2006
    • (2006) J Bone Joint Surg Am , vol.88 , Issue.SUPPL. 2 , pp. 21-24
    • Katz, J.N.1
  • 18
    • 0038405091 scopus 로고    scopus 로고
    • Comparison of neuropathic pain induced by the application of normal and mechanically compressed nucleus pulposus to lumbar nerve roots in the rat
    • DOI 10.1016/S0736-0266(02)00192-4
    • Kawakami M, Hashizume H, Nishi H, Matsumoto T, Tamaki T, Kuribayashi K: Comparison of neuropathic pain induced by the application of normal and mechanically compressed nucleus pulposus to lumbar nerve roots in the rat. J Orthop Res 21:535-539, 2003 (Pubitemid 36546821)
    • (2003) Journal of Orthopaedic Research , vol.21 , Issue.3 , pp. 535-539
    • Kawakami, M.1    Hashizume, H.2    Nishi, H.3    Matsumoto, T.4    Tamaki, T.5    Kuribayashi, K.6
  • 19
    • 24744467562 scopus 로고    scopus 로고
    • Osteogenic protein-1 (osteogenic protein-1/bone morphogenetic protein-7) inhibits degeneration and pain-related behavior induced by chronically compressed nucleus pulposus in the rat
    • Kawakami M, Matsumoto T, Hashizume H, Kuribayashi K, Chubinskaya S, Yoshida M: Osteogenic protein-1 (osteogenic protein-1/bone morphogenetic protein-7) inhibits degeneration and pain-related behavior induced by chronically compressed nucleus pulposus in the rat. Spine 30:1933-1939, 2005
    • (2005) Spine , vol.30 , pp. 1933-1939
    • Kawakami, M.1    Matsumoto, T.2    Hashizume, H.3    Kuribayashi, K.4    Chubinskaya, S.5    Yoshida, M.6
  • 20
    • 0036124054 scopus 로고    scopus 로고
    • Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat
    • DOI 10.1016/S0736-0266(01)00114-0, PII S0736026601001140
    • Kawakami M, Matsumoto T, Hashizume H, Kuribayashi K, Tamaki T: Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat. J Orthop Res 20:376-381, 2002 (Pubitemid 34218286)
    • (2002) Journal of Orthopaedic Research , vol.20 , Issue.2 , pp. 376-381
    • Kawakami, M.1    Matsumoto, T.2    Hashizume, H.3    Kuribayashi, K.4    Tamaki, T.5
  • 21
    • 0029856176 scopus 로고    scopus 로고
    • Incision of the anulus fibrosus induces nerve root morphologic, vascular, and functional changes: An experimental study
    • DOI 10.1097/00007632-199611150-00002
    • Kayama S, Konno S, Olmarker K, Yabuki S, Kikuchi S: Incision of the anulus fibrosus induces nerve root morphologic, vascular, and functional changes: an experimental study. Spine 21:2539-2543, 1996 (Pubitemid 26419089)
    • (1996) Spine , vol.21 , Issue.22 , pp. 2539-2543
    • Kayama, S.1    Konno, S.2    Olmarker, K.3    Yabuki, S.4    Kikuchi, S.5
  • 22
    • 27144470232 scopus 로고    scopus 로고
    • Human anulus fibrosis and nucleus pulposus cells of the intervertebral disc: Effect of degeneration and culture system on cell phenotype
    • DOI 10.1097/01.brs.0000192204.89160.6d
    • Kluba T, Niemeyer T, Gaissmaier C, Gründer T: Human anulus fibrosis and nucleus pulposus cells of the intervertebral disc: effect of degeneration and culture system on cell phenotype. Spine 30:2743-2748, 2005 (Pubitemid 43011034)
    • (2005) Spine , vol.30 , Issue.24 , pp. 2743-2748
    • Kluba, T.1    Niemeyer, T.2    Gaissmaier, C.3    Grunder, T.4
  • 23
    • 33747337754 scopus 로고    scopus 로고
    • Electromyographic findings in nucleus pulposus-induced radiculopathy in the rat
    • Lee SJ, Han TR, Hyun JK, Jeon JY, Myong NH: Electromyographic findings in nucleus pulposus-induced radiculopathy in the rat. Spine 31:2053-2058, 2006
    • (2006) Spine , vol.31 , pp. 2053-2058
    • Lee, S.J.1    Han, T.R.2    Hyun, J.K.3    Jeon, J.Y.4    Myong, N.H.5
  • 24
    • 29744447597 scopus 로고    scopus 로고
    • The role of interleukin- 1 in the pathogenesis of human intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin- 1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 7:R732-R745, 2005
    • (2005) Arthritis Res Ther , vol.7
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 25
    • 14844339516 scopus 로고    scopus 로고
    • Animal models of intervertebral disc degeneration: Lessons learned
    • DOI 10.1097/01.brs.0000146498.04628.f9
    • Lotz JC: Animal models of intervertebral disc degeneration: lessons learned. Spine 29:2742-2750, 2004 (Pubitemid 40353260)
    • (2004) Spine , vol.29 , Issue.23 , pp. 2742-2750
    • Lotz, J.C.1
  • 26
    • 0032411120 scopus 로고    scopus 로고
    • Compression-induced degeneration of the intervertebral disc: An in vivo mouse model and finite-element study
    • Lotz JC, Colliou OK, Chin JR, Duncan NA, Liebenberg E: Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study. Spine 23: 2493-2506, 1998
    • (1998) Spine , vol.23 , pp. 2493-2506
    • Lotz, J.C.1    Colliou, O.K.2    Chin, J.R.3    Duncan, N.A.4    Liebenberg, E.5
  • 27
    • 13444302219 scopus 로고    scopus 로고
    • A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: Correlation between the degree of disc injury and radiological and histological appearances of disc degeneration
    • Masuda K, Aota Y, Muehleman C, Imai Y, Okuma M, Thonar EJ, et al: A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine 30:5-14, 2005 (Pubitemid 40209270)
    • (2005) Spine , vol.30 , Issue.1 , pp. 5-14
    • Masuda, K.1    Aota, Y.2    Muehleman, C.3    Imai, Y.4    Okuma, M.5    Thonar, E.J.6    Andersson, G.B.7    An, H.S.8
  • 28
    • 38149038056 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-alpha in apoptosis of dorsal root ganglion cells induced by herniated nucleus pulposus in rats
    • Murata Y, Nannmark U, Rydevik B, Takahashi K, Olmarker K: The role of tumor necrosis factor-alpha in apoptosis of dorsal root ganglion cells induced by herniated nucleus pulposus in rats. Spine 33:155-162, 2008
    • (2008) Spine , vol.33 , pp. 155-162
    • Murata, Y.1    Nannmark, U.2    Rydevik, B.3    Takahashi, K.4    Olmarker, K.5
  • 29
    • 4944267462 scopus 로고    scopus 로고
    • Distribution and appearance of tumor necrosis factor-alpha in the dorsal root ganglion exposed to experimental disc herniation in rats
    • DOI 10.1097/01.brs.0000142223.30453.e5
    • Murata Y, Onda A, Rydevik B, Takahashi K, Olmarker K: Distribution and appearance of tumor necrosis factor alpha in the dorsal root ganglion exposed to experimental disc herniation in rats. Spine 29:2235-2241, 2004 (Pubitemid 40362217)
    • (2004) Spine , vol.29 , Issue.20 , pp. 2235-2241
    • Murata, Y.1    Onda, A.2    Rydevik, B.3    Takahashi, K.4    Olmarker, K.5
  • 30
    • 0031789495 scopus 로고    scopus 로고
    • Walking analysis of rats subjected to experimental disc herniation
    • DOI 10.1007/s005860050096
    • Olmarker K, Iwabuchi M, Larsson K, Rydevik B: Walking analysis of rats subjected to experimental disc herniation. Eur Spine J 7:394-399, 1998 (Pubitemid 28505898)
    • (1998) European Spine Journal , vol.7 , Issue.5 , pp. 394-399
    • Olmarker, K.1    Iwabuchi, M.2    Larsson, K.3    Rydevik, B.4
  • 31
    • 0032411612 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury
    • DOI 10.1097/00007632-199812010-00008
    • Olmarker K, Larsson K: Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury. Spine 23:2538-2544, 1998 (Pubitemid 29003527)
    • (1998) Spine , vol.23 , Issue.23 , pp. 2538-2544
    • Olmarker, K.1    Larsson, K.2
  • 32
    • 0031770778 scopus 로고    scopus 로고
    • Pathogenesis of sciatic pain: Role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion
    • Olmarker K, Myers RR: Pathogenesis of sciatic pain: role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion. Pain 78:99-105, 1998
    • (1998) Pain , vol.78 , pp. 99-105
    • Olmarker, K.1    Myers, R.R.2
  • 33
    • 0035870863 scopus 로고    scopus 로고
    • Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: Possible implications for future pharmacologic treatment strategies of sciatica
    • DOI 10.1097/00007632-200104150-00007
    • Olmarker K, Rydevik B: Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica. Spine 26:863-869, 2001 (Pubitemid 32373971)
    • (2001) Spine , vol.26 , Issue.8 , pp. 863-869
    • Olmarker, K.1    Rydevik, B.2
  • 34
    • 0037096714 scopus 로고    scopus 로고
    • Pathogenesis of sciatic pain: A study of spontaneous behavior in rats exposed to experimental disc herniation
    • DOI 10.1097/00007632-200206150-00013
    • Olmarker K, Storkson R, Berge OG: Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc herniation. Spine 27:1312-1317, 2002 (Pubitemid 34655138)
    • (2002) Spine , vol.27 , Issue.12 , pp. 1312-1317
    • Olmarker, K.1    Storkson, R.2    Berge, O.-G.3
  • 35
    • 34247216719 scopus 로고    scopus 로고
    • Biological treatment strategies for disc degeneration: Potentials and shortcomings
    • DOI 10.1007/s00586-006-0220-y
    • Paesold G, Nerlich AG, Boos N: Biological treatment strate gies for disc degeneration: potentials and shortcomings. Eur Spine J 16:447-468, 2007 (Pubitemid 46626252)
    • (2007) European Spine Journal , vol.16 , Issue.4 , pp. 447-468
    • Paesold, G.1    Nerlich, A.G.2    Boos, N.3
  • 36
    • 0029130631 scopus 로고
    • Vascular changes and demyelination induced by the intraneural injection of tumour necrosis factor
    • Redford EJ, Hall SM, Smith KJ: Vascular changes and demyelination induced by the intraneural injection of tumour necrosis factor. Brain 118:869-878, 1995
    • (1995) Brain , vol.118 , pp. 869-878
    • Redford, E.J.1    Hall, S.M.2    Smith, K.J.3
  • 37
    • 33846070972 scopus 로고    scopus 로고
    • Stab incision for inducing intervertebral disc degeneration in the rat
    • DOI 10.1097/01.brs.0000251013.07656.45, PII 0000763220070101000004
    • Rousseau M-A, Ulrich JA, Bass EC, Rodriguez AG, Liu JJ, Lotz JC: Stab incision for inducing intervertebral disc degeneration in the rat. Spine 32:17-24, 2007 (Pubitemid 46058579)
    • (2007) Spine , vol.32 , Issue.1 , pp. 17-24
    • Rousseau, M.-A.A.1    Ulrich, J.A.2    Bass, E.C.3    Rodriguez, A.G.4    Liu, J.J.5    Lotz, J.C.6
  • 39
    • 28244497107 scopus 로고    scopus 로고
    • Animal models for human disc degeneration
    • DOI 10.1016/j.spinee.2005.02.016, PII S152994300500094X
    • Singh K, Masuda K, An HS: Animal models for human disc degeneration. Spine J 5:267S-279S, 2005 (Pubitemid 41700071)
    • (2005) Spine Journal , vol.5 , Issue.6 SUPPL.
    • Singh, K.1    Masuda, K.2    An, H.S.3
  • 40
    • 33847039868 scopus 로고    scopus 로고
    • Does facet joint inflammation induce radiculopathy? An investigation using a rat model of lumbar facet joint inflammation
    • DOI 10.1097/01.brs.0000255094.08805.2f, PII 0000763220070215000004
    • Tachihara H, Kikuchi S, Konno S, Sekiguchi M: Does facet joint inflammation induce radiculopathy?: an investigation using a rat model of lumbar facet joint inflammation. Spine 32: 406-412, 2007 (Pubitemid 46272421)
    • (2007) Spine , vol.32 , Issue.4 , pp. 406-412
    • Tachihara, H.1    Kikuchi, S.-I.2    Konno, S.-I.3    Sekiguchi, M.4
  • 41
    • 39049144760 scopus 로고    scopus 로고
    • ISSLS prize winner: Repeated disc injury causes persistent inflammation
    • Ulrich JA, Liebenberg EC, Thuillier DU, Lotz JC: ISSLS prize winner: repeated disc injury causes persistent inflammation. Spine 32:2812-2819, 2007
    • (2007) Spine , vol.32 , pp. 2812-2819
    • Ulrich, J.A.1    Liebenberg, E.C.2    Thuillier, D.U.3    Lotz, J.C.4
  • 42
    • 2042429009 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor
    • van der Poll T, Jansen PM, Van Zee KJ, Welborn MB III, de Jong I, Hack CE, et al: Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor. Blood 88:922-927, 1996
    • (1996) Blood , vol.88 , pp. 922-927
    • Van Der Poll, T.1    Jansen, P.M.2    Van Zee, K.J.3    Welborn III, M.B.4    De Jong, I.5    Hack, C.E.6
  • 43
    • 0030474099 scopus 로고    scopus 로고
    • Endoneurial injection of TNF-alpha produces neuropathic pain behaviors
    • Wagner R, Myers RR: Endoneurial injection of TNF-alpha produces neuropathic pain behaviors. Neuroreport 7:2897-2901, 1996 (Pubitemid 26426355)
    • (1996) NeuroReport , vol.7 , Issue.18 , pp. 2897-2901
    • Wagner, R.1    Myers, R.R.2
  • 44
    • 13444268945 scopus 로고    scopus 로고
    • Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: A study in surgical specimen and autopsy controls
    • Weiler C, Nerlich AG, Bachmeier BE, Boos N: Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 30:44-54, 2005 (Pubitemid 40209276)
    • (2005) Spine , vol.30 , Issue.1 , pp. 44-53
    • Weiler, C.1    Nerlich, A.G.2    Bachmeier, B.E.3    Boos, N.4
  • 45
    • 0036123303 scopus 로고    scopus 로고
    • The role of mechanical deformation in lumbar radiculopathy: An in vivo model
    • Winkelstein BA, Weinstein JN, Deleo JA: The role of mechanical deformation in lumbar radiculopathy: an in vivo model. Spine 27:27-33, 2002
    • (2002) Spine , vol.27 , pp. 27-33
    • Winkelstein, B.A.1    Weinstein, J.N.2    Deleo, J.A.3
  • 46
    • 33745700149 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-alpha in the neuropathic pain induced by lumbar 5 ventral root transection in rat
    • Xu JT, Xin WJ, Zang Y, Wu CY, Liu XG: The role of tumor necrosis factor-alpha in the neuropathic pain induced by lumbar 5 ventral root transection in rat. Pain 123:306-321, 2006
    • (2006) Pain , vol.123 , pp. 306-321
    • Xu, J.T.1    Xin, W.J.2    Zang, Y.3    Wu, C.Y.4    Liu, X.G.5
  • 47
    • 44849107741 scopus 로고    scopus 로고
    • A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings: Laboratory investigation
    • DOI 10.3171/SPI/2008/8/5/450
    • Yoon SH, Miyazaki M, Hong SW, Tow B, Morishita Y, Hu M, et al: A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings. Laboratory investigation. J Neurosurg Spine 8:450-457, 2008 (Pubitemid 351792087)
    • (2008) Journal of Neurosurgery: Spine , vol.8 , Issue.5 , pp. 450-457
    • Yoon, S.-H.1    Miyazaki, M.2    Hong, S.-W.3    Tow, B.4    Morishita, Y.5    Hu, M.6    Ahn, S.-J.7    Wang, J.C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.