Brief report: Biochemical correlates of clinical impairment in high functioning autism and asperger's disorder

Journal of Autism and Developmental Disorders

Volumn 39, Issue 7, 2009, Pages 1079-1086

  Kleinhans, Natalia M ^a   Richards, Todd ^a,b   Weaver, Kurt E ^a   Liang, Olivia ^a   Dawson, Geraldine ^b,c   Aylward, Elizabeth ^a,b,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Autism Speaks Inc   (United States)

^d SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

Amygdala; Asperger's disorder; Autism; MRS

Indexed keywords

CHOLINE; CREATINE PHOSPHATE; INOSITOL; N ACETYLASPARTIC ACID; ASPARTIC ACID; CREATINE; DRUG DERIVATIVE; N-ACETYLASPARTATE;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; ASPERGER SYNDROME; AUTISM; AUTISM DIAGNOSTIC INTERVIEW; BIOCHEMISTRY; BRAIN DISEASE; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; INTERVIEW; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; ADOLESCENT; BRAIN MAPPING; CASE CONTROL STUDY; COMPARATIVE STUDY; HEMISPHERIC DOMINANCE; HOSPITALIZATION; IMAGE PROCESSING; METABOLISM; METHODOLOGY; PROGNOSIS; TIME;

ADOLESCENT; ADULT; AMYGDALA; ASPARTIC ACID; ASPERGER SYNDROME; AUTISTIC DISORDER; BRAIN MAPPING; CASE-CONTROL STUDIES; CHOLINE; CREATINE; FEMALE; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INOSITOL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHOSPHOCREATINE; PROGNOSIS; SEVERITY OF ILLNESS INDEX; TIME FACTORS; YOUNG ADULT;

EID: 70349575429     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-009-0707-6     Document Type: Article

References (39)

1. R Adolphs 2001 The neurobiology of social cognition Current Opinion in Neurobiology 11 2 231 239 10.1016/S0959-4388(00)00202-6 11301245 10.1016/S0959-4388(00)00202-6 (Pubitemid 32289412)
2. R Adolphs L Sears J Piven 2001 Abnormal processing of social information from faces in autism Journal of Cognitive Neuroscience 13 2 232 240 10.1162/089892901564289 11244548 10.1162/089892901564289 (Pubitemid 32209765)
3. R Adolphs D Tranel S Hamann AW Young AJ Calder EA Phelps, et al. 1999 Recognition of facial emotion in nine individuals with bilateral amygdala damage Neuropsychologia 37 10 1111 1117 10.1016/S0028-3932(99)00039-1 10509833 10.1016/S0028-3932(99)00039-1 (Pubitemid 29376469)
4. DG Amaral MD Bauman CM Schumann 2003 The amygdala and autism: Implications from non-human primate studies Genes Brain & Behavior 2 5 295 302 10.1034/j.1601-183X.2003.00043.x 10.1034/j.1601-183X.2003.00043.x (Pubitemid 37345667)
5. JA Amat R Bansal R Whiteman R Haggerty J Royal BS Peterson 2008 Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults Brain and Cognition 66 2 105 114 10.1016/j.bandc. 2007.05.009 17651879 10.1016/j.bandc.2007.05.009 (Pubitemid 351163427)
6. C Ashwin S Baron-Cohen S Wheelwright M O'Riordan ET Bullmore 2006 Differential activation of the amygdala and the 'social brain' during fearful face-processing in Asperger Syndrome Neuropsychologia 1 349 363
7. EH Aylward NJ Minshew K Field BF Sparks N Singh 2002 Effects of age on brain volume and head circumference in autism Neurology 59 2 175 183 12136053
8. EH Aylward NJ Minshew G Goldstein NA Honeycutt AM Augustine KO Yates, et al. 1999 MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults Neurology 53 9 2145 2150 10599796
9. J Bachevalier KA Loveland 2006 The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism Neuroscience and Biobehavioral Reviews 30 1 97 117 10.1016/j.neubiorev.2005.07.002 16157377 10.1016/j.neubiorev.2005.07.002 (Pubitemid 41779409)
10. PB Barker BJ Soher SJ Blackband JC Chatham VP Mathews RN Bryan 1993 Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference NMR in Biomedicine 6 1 89 94 10.1002/nbm.1940060114 8384470 10.1002/nbm.1940060114
11. S Baron-Cohen HA Ring ET Bullmore S Wheelwright C Ashwin SC Williams 2000 The amygdala theory of autism Neuroscience and Biobehavioral Reviews 24 3 355 364 10.1016/S0149-7634(00)00011-7 10781695 10.1016/S0149-7634(00)00011-7 (Pubitemid 30227251)
12. S Baron-Cohen HA Ring S Wheelwright ET Bullmore MJ Brammer A Simmons, et al. 1999 Social intelligence in the normal and autistic brain: An fMRI study The European Journal of Neuroscience 11 6 1891 1898 10.1046/j.1460-9568.1999.00621. x 10336657 10.1046/j.1460-9568.1999.00621.x (Pubitemid 29240553)
13. WM Brooks SD Friedman CA Stidley 1999 Reproducibility of 1H-MRS in vivo Magnetic Resonance in Medicine 41 1 193 197 10.1002/(SICI)1522-2594(199901)41: 1<193::AID-MRM27>3.0.CO;2-P 10025629 10.1002/(SICI)1522- 2594(199901)41:1<193::AID-MRM27>3.0.CO;2-P
14. E Courchesne CM Karns HR Davis R Ziccardi RA Carper ZD Tigue, et al. 2001 Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study Neurology 57 2 245 254 11468308
15. HD Critchley EM Daly ET Bullmore SC Williams T Van Amelsvoort DM Robertson, et al. 2000 The functional neuroanatomy of social behaviour: Changes in cerebral blood flow when people with autistic disorder process facial expressions Brain 123 Pt 11 2203 2212 10.1093/brain/123.11.2203 11050021 10.1093/brain/123.11.2203
16. KM Dalton BM Nacewicz T Johnstone HS Schaefer MA Gernsbacher HH Goldsmith, et al. 2005 Gaze fixation and the neural circuitry of face processing in autism Nature Neuroscience 8 4 519 526 15750588
17. T Endo T Shioiri H Kitamura T Kimura S Endo N Masuzawa, et al. 2007 Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders Biological Psychiatry 62 9 1030 1037 10.1016/j.biopsych.2007.05.015 17631869 10.1016/j.biopsych.2007.05.015 (Pubitemid 47562375)
18. SD Friedman DW Shaw AA Artru TL Richards J Gardner G Dawson, et al. 2003 Regional brain chemical alterations in young children with autism spectrum disorder Neurology 60 1 100 107 12525726
19. L Gabis H Wei A Azizian C DeVincent A Tudorica Y Kesner-Baruch, et al. 2008 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders Journal of Child Neurology 23 7 766 774 10.1177/0883073808315423 18487520 10.1177/ 0883073808315423 (Pubitemid 351998165)
20. RE Jung WM Brooks RA Yeo SJ Chiulli DC Weers WL Sibbitt Jr 1999 Biochemical markers of intelligence: A proton MR spectroscopy study of normal human brain Proc Biol Sci 266 1426 1375 1379 10.1098/rspb.1999.0790 10445292 10.1098/rspb.1999.0790 (Pubitemid 29353789)
21. RE Jung RA Yeo SJ Chiulli WL Sibbitt Jr WM Brooks 2000 Myths of neuropsychology: Intelligence, neurometabolism, and cognitive ability The Clinical Neuropsychologist 14 4 535 545 10.1076/clin.14.4.535.7198 11262722
22. NM Kleinhans T Richards L Sterling KC Stegbauer R Mahurin LC Johnson, et al. 2008 Abnormal functional connectivity in autism spectrum disorders during face processing Brain 131 Pt 4 1000 1012 10.1093/brain/awm334 18234695 10.1093/brain/awm334
23. C Lord S Risi L Lambrecht E Cook B Leventhal P DiLavore, et al. 2000 The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism Journal of Autism and Developmental Disorders 30 3 205 223 10.1023/A:1005592401947 11055457 10.1023/A:1005592401947 (Pubitemid 30748714)
24. C Lord M Rutter A Le Couteur 1994 Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders Journal of Autism and Developmental Disorders 24 5 659 685 10.1007/BF02172145 7814313 10.1007/BF02172145 (Pubitemid 24309810)
25. J Munson G Dawson R Abbott S Faja SJ Webb SD Friedman, et al. 2006 Amygdalar volume and behavioral development in autism Archives of General Psychiatry 63 6 686 693 10.1001/archpsyc.63.6.686 16754842 10.1001/archpsyc.63. 6.686 (Pubitemid 43848300)
26. DG Murphy HD Critchley N Schmitz G McAlonan T Van Amelsvoort D Robertson, et al. 2002 Asperger syndrome: A proton magnetic resonance spectroscopy study of brain Archives of General Psychiatry 59 10 885 891 10.1001/archpsyc.59.10.885 12365875 10.1001/archpsyc.59.10.885
27. BM Nacewicz KM Dalton T Johnstone MT Long EM McAuliff TR Oakes, et al. 2006 Amygdala volume and nonverbal social impairment in adolescent and adult males with autism Archives of General Psychiatry 63 12 1417 1428 10.1001/archpsyc.63.12.1417 17146016 10.1001/archpsyc.63.12.1417 (Pubitemid 44878525)
28. H Otsuka M Harada K Mori S Hisaoka H Nishitani 1999 Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: An 1H-MR spectroscopy study Neuroradiology 41 7 517 519 10.1007/s002340050795 10450847 10.1007/s002340050795 (Pubitemid 29348670)
29. Page, L. A., Daly, E., Schmitz, N., Simmons, A., Toal, F., Deeley, Q., et al. (2006). In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism. American Journal of Psychiatry, 163, 2189-2192.
30. A Pfefferbaum E Adalsteinsson D Spielman EV Sullivan KO Lim 1999 In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: Effects of normal aging Magnetic Resonance in Medicine 41 2 276 284 10.1002/(SICI)1522-2594(199902)41: 2<276::AID-MRM10>3.0.CO;2-8 10080274 10.1002/(SICI)1522- 2594(199902)41:2<276::AID-MRM10>3.0.CO;2-8
31. K Pierce RA Muller J Ambrose G Allen E Courchesne 2001 Face processing occurs outside the fusiform 'face area' in autism: Evidence from functional MRI Brain 124 Pt 10 2059 2073 10.1093/brain/124.10.2059 11571222 10.1093/brain/124.10.2059
32. SW Provencher 1993 Estimation of metabolite concentrations from localized in vivo proton NMR spectra Magnetic Resonance in Medicine 30 6 672 679 10.1002/mrm.1910300604 8139448 10.1002/mrm.1910300604 (Pubitemid 23360802)
33. E Redcay E Courchesne 2005 When is the brain enlarged in autism? A meta-analysis of all brain size reports Biological Psychiatry 58 1 1 9 10.1016/j.biopsych.2005.03.026 15935993 10.1016/j.biopsych.2005.03.026 (Pubitemid 40909929)
34. CM Schumann DG Amaral 2006 Stereological analysis of amygdala neuron number in autism The Journal of Neuroscience 26 29 7674 7679 10.1523/JNEUROSCI.1285-06.2006 16855095 10.1523/JNEUROSCI.1285-06.2006 (Pubitemid 44315187)
35. CM Schumann J Hamstra BL Goodlin-Jones LJ Lotspeich H Kwon MH Buonocore, et al. 2004 The amygdala is enlarged in children but not adolescents with autism; The hippocampus is enlarged at all ages The Journal of Neuroscience 24 28 6392 6401 10.1523/JNEUROSCI.1297-04.2004 15254095 10.1523/JNEUROSCI.1297-04. 2004 (Pubitemid 38944230)
36. BF Sparks SD Friedman DW Shaw EH Aylward D Echelard AA Artru, et al. 2002 Brain structural abnormalities in young children with autism spectrum disorder Neurology 59 2 184 192 12136055
37. AT Wang M Dapretto AR Hariri M Sigman SY Bookheimer 2004 Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder Journal of the American Academy of Child and Adolescent Psychiatry 43 4 481 490 10.1097/00004583-200404000-00015 15187809 10.1097/00004583-200404000-00015 (Pubitemid 38812389)
38. D Watson R Friend 1969 Measurement of social-evaluative anxiety Journal of Consulting and Clinical Psychology 33 4 448 457 10.1037/h0027806 5810590 10.1037/h0027806
39. JH Williams GD Waiter A Gilchrist DI Perrett AD Murray A Whiten 2006 Neural mechanisms of imitation and 'mirror neuron' functioning in autistic spectrum disorder Neuropsychologia 44 4 610 621 10.1016/j.neuropsychologia.2005. 06.010 16140346 10.1016/j.neuropsychologia.2005.06.010 (Pubitemid 43113384)