Cefepime-associated Status epilepticus in an ICU patient with renal failure

Journal of Chemotherapy

Volumn 21, Issue 4, 2009, Pages 452-454

  Shaheen, T ^a   Volles, D ^a   Calland, F ^a   Sifri, C D ^a   Mytinger, J ^a   Hagspiel, K ^a   Sawyer, R ^a   Bonatti, Hugo ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; CEFEPIME; CIPROFLOXACIN; CREATININE; ETIRACETAM; LORAZEPAM; MIDAZOLAM; PIPERACILLIN PLUS TAZOBACTAM; UREA; VANCOMYCIN; ANTIINFECTIVE AGENT; CEPHALOSPORIN DERIVATIVE;

AGED; ANAMNESIS; ARTICLE; BACTERIUM CULTURE; CASE REPORT; CLINICAL FEATURE; COMORBIDITY; CONTINUOUS INFUSION; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DOSE CALCULATION; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; FEMALE; HUMAN; INTENSIVE CARE UNIT; KIDNEY FAILURE; KIDNEY FUNCTION; LAPAROTOMY; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PSEUDOMONAS INFECTION; SEPSIS; TREATMENT DURATION; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL; CHEMICALLY INDUCED DISORDER;

AGED; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; FEMALE; HUMANS; INTENSIVE CARE UNITS; KIDNEY FAILURE; STATUS EPILEPTICUS;

EID: 70349562605     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.2009.21.4.452     Document Type: Article

References (19)

1. Abanades S, Nolla J, Rodriguez-Campello A, Pedro C, Valls A, Farre M. Reversible coma secondary to cefepime neurotoxicity. Ann Pharmacother. 2004;38(4):606-608 (Pubitemid 38352223)
2. Barbey F, Bugnon D, Wauters JP. Severe neurotoxicity of cefepime in uremic patients. Ann Intern Med. 2001;135(11):1011. (Pubitemid 33131630)
3. Capparelli FJ, Diaz MF, Hlavnika A, Wainsztein NA, Leiguarda R, Del Castillo ME. Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. Neurology. 2005;65(11):1840.
4. Garces EO, Andrade de Anzambuja MF, da Silva D, Bragatti JA, Jacoby T, Saldanha Thome F. Renal failure is a risk factor for cefepime-induced encephalopathy. J Nephrol. 2008;21(4):526-534
5. Wong KM, Chan WK, Chan YH, Li CS. Cefepime-related neurotoxicity in a haemodialysis patient. Nephrol Dial Transplant. 1999;14(9):2265-2266
6. Chatellier D, Jourdain M, Mangalaboyi J, Ader F, Chopin C, Derambure P, et al. Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure. Intensive Care Med. 2002;28(2):214-217 (Pubitemid 34293837)
7. Ferrara N, Abete P, Giordano M, Ferrara P, Carnovale V, Leosco D, et al. Neurotoxicity induced by Cefepime in a very old hemodialysis patient. Clin Nephrol. 2003;59(5):388-390 (Pubitemid 36592216)
8. Lin CS, Cheng CJ, Chou CH, Lin SH. Piperacillin/tazobactam-induced seizure rapidly reversed by high flux hemodialysis in a patient on peritoneal dialysis. Am J Med Sci. 2007;333(3):181-184
9. Lam S, Gomolin IH. Cefepime neurotoxicity: case report, pharmacokinetic considerations, and literature review. Pharmacotherapy. 2006;26(8):1169-1174 (Pubitemid 44167825)
10. Bresson J, Paugam-Burtz C, Josserand J, Bardin C, Mantz J, Pease S. Cefepime overdosage with neurotoxicity recovered by high-volume haemofiltration. J Antimicrob Chemother. 2008;62(4):849-850
11. Yahav D, Paul M, Fraser A, Sarid N, Leibovici L. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis. 2007;7(5):338-348 (Pubitemid 46591956)
12. Sonck J, Laureys G, Verbeelen D. The neurotoxicity and safety of treatment with cefepime in patients with renal failure. Nephrol Dial Transplant. 2008;23(3):966-970 (Pubitemid 351767571)
13. Drago L, De Vecchi E. The safety of cefepime in the treatment of infection. Expert Opin Drug Saf. 2008;7(4):377-387
14. Dakdouki GK, Al-Awar GN. Cefepime-induced encephalopathy. Int J Infect Dis. 2004;8(1):59-61.
15. Fernandez-Torre JL. Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. Neurology. 2006 25;67(2):367; author reply
16. Sugimoto M, Uchida I, Mashimo T, Yamazaki S, Hatano K, Ikeda F, et al. Evidence for the involvement of GABA(A) receptor blockade in convulsions induced by cephalosporins. Neuropharmacology. 2003;45(3):304-314
17. Stahlmann R, Lode H. fluoroquinolones in the elderly: safety considerations. Drugs Aging. 2003;20(4):289-302. (Pubitemid 36403432)
18. Neu HC. Safety of cefepime: a new extended-spectrum parenteral cephalosporin. Am J Med. 1996;100(6A):68S-75S.
19. Chow KM, Szeto CC, Hui AC, Wong TY, Li PK. Retrospective review of neurotoxicity induced by cefepime and ceftazidime. Pharmacotherapy. 2003;23(3):369-373