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Volumn 75, Issue 3, 2009, Pages 854-861

Combination of Vandetanib, Radiotherapy, and Irinotecan in the LoVo Human Colorectal Cancer Xenograft Model

Author keywords

Angiogenesis inhibitor; CPT 11; LoVo colorectal cancer; Radiotherapy; Vandetanib

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTITUMOR EFFECT; ATHYMIC; COLORECTAL CANCER; COLORECTAL TUMORS; CPT-11; CYTOTOXIC; HIND LIMBS; INTRAPERITONEALLY; IRINOTECAN; LOVO CELLS; LOVO COLORECTAL CANCER; PHOSPHATE-BUFFERED SALINES; RECEPTOR TYROSINE KINASE; TUMOR GROWTH; TUMOR VOLUMES; VANDETANIB;

EID: 70349546300     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.06.016     Document Type: Article
Times cited : (16)

References (42)
  • 1
    • 0141613762 scopus 로고    scopus 로고
    • Capecitabine and irinotecan as first-line chemotherapy in patients with metastatic colorectal cancer: Results of an extended phase I study
    • Tewes M., Schleucher N., Achterrath W., et al. Capecitabine and irinotecan as first-line chemotherapy in patients with metastatic colorectal cancer: Results of an extended phase I study. Ann Oncol 14 (2003) 1442-1448
    • (2003) Ann Oncol , vol.14 , pp. 1442-1448
    • Tewes, M.1    Schleucher, N.2    Achterrath, W.3
  • 2
    • 0037022292 scopus 로고    scopus 로고
    • Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
    • Roberts R.B., Min L., Washington M.K., et al. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99 (2002) 1521-1526
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 1521-1526
    • Roberts, R.B.1    Min, L.2    Washington, M.K.3
  • 3
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351 (2004) 337-345
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 4
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 5
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Carlomagno F., Vitagliano D., Guida T., et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 62 (2002) 7284-7290
    • (2002) Cancer Res , vol.62 , pp. 7284-7290
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 6
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F., Caputo R., Damiano V., et al. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res 9 (2003) 1546-1556
    • (2003) Clin Cancer Res , vol.9 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 7
    • 21244475061 scopus 로고    scopus 로고
    • ZD6474-a novel inhibitor of VEGFR and EGFR tyrosine kinase activity
    • Ryan A.J., and Wedge S.R. ZD6474-a novel inhibitor of VEGFR and EGFR tyrosine kinase activity. Br J Cancer 92 Suppl 1 (2005) S6-S13
    • (2005) Br J Cancer , vol.92 , Issue.SUPPL. 1
    • Ryan, A.J.1    Wedge, S.R.2
  • 8
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge S.R., Ogilvie D.J., Dukes M., et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 62 (2002) 4645-4655
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 9
    • 33646915238 scopus 로고    scopus 로고
    • VEGF-associated tyrosine kinase inhibition increases the tumor response to single and fractionated dose radiotherapy
    • Brazelle W.D., Shi W., and Siemann D.W. VEGF-associated tyrosine kinase inhibition increases the tumor response to single and fractionated dose radiotherapy. Int J Radiat Oncol Biol Phys 65 (2006) 836-841
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 836-841
    • Brazelle, W.D.1    Shi, W.2    Siemann, D.W.3
  • 10
    • 23044500424 scopus 로고    scopus 로고
    • Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma
    • Damiano V., Melisi D., Bianco C., et al. Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma. Clin Cancer Res 11 (2005) 5639-5644
    • (2005) Clin Cancer Res , vol.11 , pp. 5639-5644
    • Damiano, V.1    Melisi, D.2    Bianco, C.3
  • 11
    • 29244461412 scopus 로고    scopus 로고
    • ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinase activity in combination with radiotherapy
    • Frederick B., Gustafson D., Bianco C., et al. ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinase activity in combination with radiotherapy. Int J Radiat Oncol Biol Phys 64 (2006) 33-37
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 33-37
    • Frederick, B.1    Gustafson, D.2    Bianco, C.3
  • 12
    • 38349085651 scopus 로고    scopus 로고
    • Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model
    • Sandstrom M., Johansson M., Bergstrom P., et al. Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model. J Neurooncol 88 (2008) 1-9
    • (2008) J Neurooncol , vol.88 , pp. 1-9
    • Sandstrom, M.1    Johansson, M.2    Bergstrom, P.3
  • 13
    • 11144223542 scopus 로고    scopus 로고
    • ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity
    • Williams K.J., Telfer B.A., Brave S., et al. ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity. Clin Cancer Res 10 (2004) 8587-8593
    • (2004) Clin Cancer Res , vol.10 , pp. 8587-8593
    • Williams, K.J.1    Telfer, B.A.2    Brave, S.3
  • 14
    • 0345734200 scopus 로고    scopus 로고
    • Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells
    • Koizumi F., Kanzawa F., Ueda Y., et al. Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells. Int J Cancer 108 (2004) 464-472
    • (2004) Int J Cancer , vol.108 , pp. 464-472
    • Koizumi, F.1    Kanzawa, F.2    Ueda, Y.3
  • 15
    • 0842304926 scopus 로고    scopus 로고
    • Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo
    • Nyati M.K., Maheshwari D., Hanasoge S., et al. Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo. Clin Cancer Res 10 (2004) 691-700
    • (2004) Clin Cancer Res , vol.10 , pp. 691-700
    • Nyati, M.K.1    Maheshwari, D.2    Hanasoge, S.3
  • 16
    • 33745938085 scopus 로고    scopus 로고
    • Tissue distribution and metabolism of the tyrosine kinase inhibitor ZD6474 (Zactima) in tumor-bearing nude mice following oral dosing
    • Gustafson D.L., Bradshaw-Pierce E.L., Merz A.L., et al. Tissue distribution and metabolism of the tyrosine kinase inhibitor ZD6474 (Zactima) in tumor-bearing nude mice following oral dosing. J Pharmacol Exp Ther 318 (2006) 872-880
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 872-880
    • Gustafson, D.L.1    Bradshaw-Pierce, E.L.2    Merz, A.L.3
  • 17
    • 33745590870 scopus 로고    scopus 로고
    • Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases
    • Morelli M.P., Cascone T., Troiani T., et al. Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases. J Cell Physiol 208 (2006) 344-353
    • (2006) J Cell Physiol , vol.208 , pp. 344-353
    • Morelli, M.P.1    Cascone, T.2    Troiani, T.3
  • 18
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • Morabito A., Piccirillo M.C., Falasconi F., et al. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions. Oncologist 14 (2009) 378-390
    • (2009) Oncologist , vol.14 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3
  • 19
    • 64649096230 scopus 로고    scopus 로고
    • Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer
    • Michael M., Gibbs P., Smith R., et al. Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer. Invest New Drugs 27 (2009) 253-261
    • (2009) Invest New Drugs , vol.27 , pp. 253-261
    • Michael, M.1    Gibbs, P.2    Smith, R.3
  • 20
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part, double-blind, randomized Phase II Study
    • Natale R.B., Bodkin D., Govindan R., et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part, double-blind, randomized Phase II Study. J Clin Oncol 27 (2009) 2523-2529
    • (2009) J Clin Oncol , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 21
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson D.H., Fehrenbacher L., Novotny W.F., et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22 (2004) 2184-2191
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 22
    • 10744227199 scopus 로고    scopus 로고
    • Circulating angiogenic factors and the risk of preeclampsia
    • Levine R.J., Maynard S.E., Qian C., et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350 (2004) 672-683
    • (2004) N Engl J Med , vol.350 , pp. 672-683
    • Levine, R.J.1    Maynard, S.E.2    Qian, C.3
  • 23
    • 34247899028 scopus 로고    scopus 로고
    • Design of clinical trials of radiation combined with antiangiogenic therapy
    • Senan S., and Smit E.F. Design of clinical trials of radiation combined with antiangiogenic therapy. Oncologist 12 (2007) 465-477
    • (2007) Oncologist , vol.12 , pp. 465-477
    • Senan, S.1    Smit, E.F.2
  • 24
    • 36149001692 scopus 로고    scopus 로고
    • Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer
    • Shibuya K., Komaki R., Shintani T., et al. Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 69 (2007) 1534-1543
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 1534-1543
    • Shibuya, K.1    Komaki, R.2    Shintani, T.3
  • 25
    • 66249135629 scopus 로고    scopus 로고
    • Combined inhibition of the VEGFR and EGFR signaling pathways in the treatment of NSCLC
    • Pennell N.A., and Lynch Jr. T.J. Combined inhibition of the VEGFR and EGFR signaling pathways in the treatment of NSCLC. Oncologist 14 (2009) 399-411
    • (2009) Oncologist , vol.14 , pp. 399-411
    • Pennell, N.A.1    Lynch Jr., T.J.2
  • 26
    • 35948979658 scopus 로고    scopus 로고
    • Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model
    • Troiani T., Serkova N.J., Gustafson D.L., et al. Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model. Clin Cancer Res 13 (2007) 6450-6458
    • (2007) Clin Cancer Res , vol.13 , pp. 6450-6458
    • Troiani, T.1    Serkova, N.J.2    Gustafson, D.L.3
  • 27
    • 33845789166 scopus 로고    scopus 로고
    • Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer
    • Bianco C., Giovannetti E., Ciardiello F., et al. Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer. Clin Cancer Res 12 (2006) 7099-7107
    • (2006) Clin Cancer Res , vol.12 , pp. 7099-7107
    • Bianco, C.1    Giovannetti, E.2    Ciardiello, F.3
  • 28
    • 0038626211 scopus 로고    scopus 로고
    • Tumor response to radiotherapy regulated by endothelial cell apoptosis
    • Garcia-Barros M., Paris F., Cordon-Cardo C., et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300 (2003) 1155-1159
    • (2003) Science , vol.300 , pp. 1155-1159
    • Garcia-Barros, M.1    Paris, F.2    Cordon-Cardo, C.3
  • 29
    • 0035854479 scopus 로고    scopus 로고
    • Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
    • Paris F., Fuks Z., Kang A., et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293 (2001) 293-297
    • (2001) Science , vol.293 , pp. 293-297
    • Paris, F.1    Fuks, Z.2    Kang, A.3
  • 30
    • 0000091450 scopus 로고    scopus 로고
    • The effect of ionizing radiation on signal transduction: Antibodies to EGF receptor sensitize A431 cells to radiation
    • Balaban N., Moni J., Shannon M., et al. The effect of ionizing radiation on signal transduction: Antibodies to EGF receptor sensitize A431 cells to radiation. Biochim Biophys Acta 1314 (1996) 147-156
    • (1996) Biochim Biophys Acta , vol.1314 , pp. 147-156
    • Balaban, N.1    Moni, J.2    Shannon, M.3
  • 31
    • 0030772168 scopus 로고    scopus 로고
    • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
    • Schmidt-Ullrich R.K., Mikkelsen R.B., Dent P., et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15 (1997) 1191-1197
    • (1997) Oncogene , vol.15 , pp. 1191-1197
    • Schmidt-Ullrich, R.K.1    Mikkelsen, R.B.2    Dent, P.3
  • 32
    • 33745059265 scopus 로고    scopus 로고
    • Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non-small cell lung cancer cells
    • Van S.S., Kyula J., Kelly D.M., et al. Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non-small cell lung cancer cells. Mol Cancer Ther 5 (2006) 1154-1165
    • (2006) Mol Cancer Ther , vol.5 , pp. 1154-1165
    • Van, S.S.1    Kyula, J.2    Kelly, D.M.3
  • 33
    • 0035555569 scopus 로고    scopus 로고
    • Squamous cell head and neck cancer: Evidence of angiogenic regeneration during radiotherapy
    • Koukourakis M.I., Giatromanolaki A., Sivridis E., et al. Squamous cell head and neck cancer: Evidence of angiogenic regeneration during radiotherapy. Anticancer Res 21 (2001) 4301-4309
    • (2001) Anticancer Res , vol.21 , pp. 4301-4309
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3
  • 34
    • 0036554864 scopus 로고    scopus 로고
    • Tumor-specific regulation of angiogenic growth factors and their receptors during recovery from cytotoxic therapy
    • Taylor A.P., Osorio L., Craig R., et al. Tumor-specific regulation of angiogenic growth factors and their receptors during recovery from cytotoxic therapy. Clin Cancer Res 8 (2002) 1213-1222
    • (2002) Clin Cancer Res , vol.8 , pp. 1213-1222
    • Taylor, A.P.1    Osorio, L.2    Craig, R.3
  • 35
    • 0033564974 scopus 로고    scopus 로고
    • Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • Gorski D.H., Beckett M.A., Jaskowiak N.T., et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59 (1999) 3374-3378
    • (1999) Cancer Res , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3
  • 36
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., and Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8 (2008) 592-603
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 37
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O., Hicklin D.J., Bergers G., et al. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8 (2005) 299-309
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3
  • 38
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R., Lu K.V., Petritsch C., et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13 (2008) 206-220
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3
  • 39
    • 54849186800 scopus 로고    scopus 로고
    • Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts
    • Sasaki T., Tanno S., Shibukawa K., et al. Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts. Int J Oncol 33 (2008) 525-532
    • (2008) Int J Oncol , vol.33 , pp. 525-532
    • Sasaki, T.1    Tanno, S.2    Shibukawa, K.3
  • 40
    • 70349552354 scopus 로고    scopus 로고
    • Showalter TN, Daroczi B, Halko R, et al. ZD6474 enhances radiation therapy in human glioblastoma xenografts which contain the EGFRvIII mutation or overexpress wtEGFR. Abstract, Radiation Research Society Annual Meeting 2008 (Boston, MA) Radiation Research Society Annual Meeting 2008.
    • Showalter TN, Daroczi B, Halko R, et al. ZD6474 enhances radiation therapy in human glioblastoma xenografts which contain the EGFRvIII mutation or overexpress wtEGFR. Abstract, Radiation Research Society Annual Meeting 2008 (Boston, MA) Radiation Research Society Annual Meeting 2008.
  • 41
    • 84887212345 scopus 로고    scopus 로고
    • Combination of two but not three current targeted drugs can improve therapy of chronic myeloid leukemia
    • Komarova N.L., Katouli A.A., and Wodarz D. Combination of two but not three current targeted drugs can improve therapy of chronic myeloid leukemia. PLoS ONE 4 (2009) e4423
    • (2009) PLoS ONE , vol.4
    • Komarova, N.L.1    Katouli, A.A.2    Wodarz, D.3
  • 42
    • 61349153697 scopus 로고    scopus 로고
    • Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines with MET amplification
    • Okabe T., Okamoto I., Tsukioka S., et al. Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines with MET amplification. Clin Cancer Res 15 (2009) 907-913
    • (2009) Clin Cancer Res , vol.15 , pp. 907-913
    • Okabe, T.1    Okamoto, I.2    Tsukioka, S.3


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