Biochemical studies on the effect of curcumin and embelin during N-nitrosodiethylamine/phenobarbital induced-hepatocarcinogenesis in wistar rats

African Journal of Biotechnology

Volumn 8, Issue 18, 2009, Pages 4618-4622

  Jagadeesh, M C ^a   Sreepriya, M ^a   Bali, Geetha ^a   Manjulakumari, D ^a  

^a BANGALORE UNIVERSITY   (India)

Author keywords

Cholesterolaemia; Curcumin; Embelin; N nitrosodiethylamine; Phenobarbital; Triglyceridaemia

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; CURCUMIN; DIETHYLNITROSAMINE; EMBELIN; FATTY ACID; GLUCOSE; LIPID; LOW DENSITY LIPOPROTEIN; PHENOBARBITAL; TRIACYLGLYCEROL LIPASE; UREA; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CURCUMA LONGA; DRUG EFFECT; EMBELIA; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; KIDNEY FUNCTION TEST; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER CARCINOGENESIS; MALE; NONHUMAN; RAT; RAT STRAIN; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; WISTAR RAT;

CURCUMA LONGA; EMBELIA RIBES; RATTUS; RATTUS NORVEGICUS;

EID: 70349521966     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Ravelo AG, Estevez-Braun A, Chavez-Orellana H, Perez-Sacau E, Mesa-Siverio D (2004). Recent studies on natural products as anticancer agents. Curr. Top. Med. Chem. 4: p. 241.
2. Modzelewska A, Sur S, Kumar SK, Khan SR (2005). Sesquiterpenes: natural products that decrease cancer growth. Curr. Med. Chem. Anticancer Agents, 5: p. 477.
3. Atal CK, Siddiqui MA, Zutshi U, Amla V, Johri RK, Rao PG, Kour S (1984). Non-narcotic orally effective, centrally acting analgesic from an Ayurvedic drug. J. Ethnopharmacol. 11: p. 309. (Pubitemid 14045968)
4. Zutshi U, Sharma SC, Kaul JL, Atal CK (1990). Kinetic fate of potassium embelate, a non-narcotic centrally acting analgesic after oral and intravenous administration. Pharmacology, 40: p. 179. (Pubitemid 20120986)
5. Gupta S, Sanyal SN, Kanwar U (1989). Antispermatogenic effect of embelin, a plant benzoquinone, on male albino rats in vivo and in vitro. Contraception, 39(3): 307-320. (Pubitemid 19057479)
6. Agarwal S, Chauhan S, Mathur R (1986). Antifertility effects of embelin in male rats. Andrologia, 18(2): 125-131 (Pubitemid 16110361)
7. Chitra M, Sukumar E, Devi CS (1995). Thymidine uptake and lipid peroxidation by tumor cells on embelin treatment: an in vitro study. Oncology, 52(1): 66-68.
8. Chitra M, Sukumar E, Suja V, Devi CS (1994). Antitumor, antiinflammatory and analgesic property of embelin, a plant product. Chemotherapy, 40(2): 109-113 (Pubitemid 2019281)
9. Chan WH, Yu JS, Yang SD (2000). Apoptotic signaling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2. Biochem J. 351: p. 221.
10. Rukkumani R, SriBalasubashini MN, Menon VP (2003). Protective effects of curcumin and photo-irradiated curcumin on circulatory lipids and lipid peroxidation products in alcohol and polyunsaturated fatty acid-induced toxicity. Phytother. Res. 17: p. 925.
11. Handler N, Jaeger W, Puschacher H, Leisser K, Erker T (2007). Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chem. Pharm. Bull. 55: p. 64.
12. Sreepriya M, Bali G (2005). Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepato-carcinogenesis in Wistar rats. Fitoterapia, 76: p. 549. (Pubitemid 41749743)
13. Sreepriya M, Bali G (2006). Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital induced hepatocarcinogenesis in Wistar rats. Mol. Cell Biochem. 284: p. 49.
14. Yoshiji H, Nakae D, Kinugasa T, Matsuzaki M, Denda A, Tsujii T, Konishi Y (1991). Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethyl-nitrosamine and promoted by phenobarbital. Br. J. Cancer, 64: p. 839.
15. Park TJ, Kim HS, Byun KH, Jang JJ, Lee YS, Lim IK (2001). Sequential changes in hepatocarcinogenesis induced by diethyl-nitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16 (INK4A) exon 1 in hepatocellular carcinoma. Mol. Carcinog. 30: p. 138.
16. Loeppen S, Schneider D, Gaunitz F, Gebhardt R, Kurek R, Buchmann A, Schwarz M (2002). Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res. 62: p. 5685. (Pubitemid 35204722)
17. Sasaki T, Matsui S (1972). Effect of acetic acid concentration on the colour reaction in the O-toluidine-boric acid method for blood glucose determination. Rinsho Kagaku. 1: p. 346.
18. Natelson S, Scott ML, Beffa C (1951). A rapid method for the estimation of urea in biologic fluids. Am. J. Clin. Pathol. 21: p. 275.
19. Broad J, Sirota JH (1948). Renal clearance of endogenous Creatinine in man. J. Clin. Invest. 27: p. 645.
20. Parekh AC, Jung DH (1970). Cholesterol determination with ferric acetate-uranyl acetate and sulphuric acid-ferrous sulphite reagents. Anal. Chem. 42: p. 1423.
21. Foster LB, Dunn RT (1973). Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin. Chem. 196: p. 338.
22. Hron WT, Menahan LA (1981). A sensitive method for the determination of free fatty acids in plasma. J. Lipid Res.122: p. 377.
23. Pereira MA, Herren-Freund SL, Britt AL, Khoury MM (1984). Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats. J. Natl. Cancer Inst. 72: p. 741.
24. Watanabe T, Sugie S, Okamoto K, Rahman KM, Ushida J, Mori H (2001). Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. Jpn. J. Cancer Res. 92: p. 603.
25. Kikuchi E, Fukui H, Matsumoto M, Tsujita M, Matsumura M, Uemura M, Sujii T (1994). Effect of prostaglandin E1 on experimental acute hepatic failure in rabbits: prostaglandin E1 prevents the development of multiple-organ failure. J. Hepatol. 20: p. 478. (Pubitemid 24146361)
26. Anandan R, Priya MS, Devi KP, Devaki T (1999). Protective effect of Picrorhiza kurroa extract against D-galactosamine-induced hepatitis in rats. Med. Sci. Res. 27: p. 127.
27. Schmike RT (1962). Adaptive characteristics of urea cycle enzyme in the rat. J. Biol. Chem. 237: p. 469.
28. Kuklin AI, Mynatt RL, Klebig ML, Kiefer LL, Wilkison WO, Woychik RP, Michaud EJ (2004). Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes. Mol. Cancer. 3: p. 17.
29. Plaa GL, Wewitt WR (1989). Detection and evaluation of chemically induced liver injury. In: Hayes WA (ed). Principles and methods of toxicology, Second edition, Raven Press Ltd., New York p. 599.
30. Dianzani MU, Slatter (1978). Biochemical aspects of fatty liver. In: Slatter TF (ed). Biochemical mechanisms of liver injury, Academic Press New York. p. 45.
31. Jiang J, Nilsson-Ehle P, Xu N (2006). Influence of liver cancer on lipid and lipoprotein metabolism. Lipids Health Dis. 3: p. 5.