Leukoencephalopathy with cognitive impairment following tocilizumab for the treatment of rheumatoid arthritis (RA)

Internal Medicine

Volumn 48, Issue 15, 2009, Pages 1307-1309

  Kobayashi, Katsuya ^a   Okamoto, Yoko ^a   Inoue, Haruhisa ^a   Usui, Takashi ^a   Ihara, Masafumi ^a   Kawamata, Jun ^a   Miki, Yukio ^a   Mimori, Tsuyeno ^a   Tomimoto, Hidekazu ^b   Takahashi, Ryosuke ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b MIE UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cognitive impairment; Interleukin 6; Leukoencephalopathy; MRI; Rheumatoid arthritis; Tocilizumab

Indexed keywords

ANTINUCLEAR ANTIBODY; ATLIZUMAB; HEMOGLOBIN A1C; IMMUNOGLOBULIN G; PREDNISOLONE; RHEUMATOID FACTOR; STROMELYSIN; VIRUS DNA;

ACHILLES REFLEX; AGED; ANKYLOSIS; ANTIBODY BLOOD LEVEL; ARTICLE; BEHAVIOR DISORDER; BRAIN FUNCTION; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; DEMENTIA; DRUG EFFICACY; DRUG WITHDRAWAL; EDEMA; ELECTROENCEPHALOGRAPHY; ENZYME BLOOD LEVEL; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; JC VIRUS; LEUKOENCEPHALOPATHY; MINI MENTAL STATE EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SPEECH DISORDER;

AGED; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; COGNITION DISORDERS; FEMALE; HUMANS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MAGNETIC RESONANCE IMAGING; RECEPTORS, INTERLEUKIN-6;

EID: 70349518575     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.48.1926     Document Type: Article

References (7)

1. Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 334: 494-500, 1996.
2. Shimono T, Miki Y, Toyoda H, et al. MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients. Eur Radiol 13: 986-993, 2003.
3. Yamamoto M, Takahashi H, Wakasugi H, et al. Leukoencephalopathy during administration of etanercept for refractory rheumatoid arthritis. Mod Rheumatol 17: 72-74, 2007.
4. Roos JC. Neurological complication of infliximab. J Rheumatol 34: 236-237, 2007.
5. US Food and Drug Administration. FDA alert: rituximab (marketed as Rituxan). December 2006.
6. Van Assche G, Van Ranst M, Sciot R, et al. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 353: 362-368, 2005.
7. Suzuki S, Tanaka K, Suzuki N. Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects. J Cereb Blood Flow Metab 29: 464-479, 2009.