Diastereoselective, large-scale synthesis of β-amino acids via asymmetric aza-Michael addition as α2δ ligands for the treatment of generalized anxiety disorder and insomnia

Tetrahedron Letters

Volumn 50, Issue 46, 2009, Pages 6325-6328

  Magano, Javier ^a   Bowles, Daniel ^a   Conway, Brian ^a   Nanninga, Thomas N ^b   Winkle, Derick D ^c  

^a PFIZER INC   (United States)

^b Bridge Organics   (United States)

^c Pleotint LLC   (United States)

Author keywords

2 Ligand; Amino acid; Asymmetric aza Michael addition; Asymmetric Michael addition; Generalized anxiety disorder; Insomnia

Indexed keywords

ALPHA2DELTA LIGAND; AMINO ACID DERIVATIVE; BETA AMINO ACID; CALCIUM CHANNEL; CITRONELLOL; LIGAND; OXAZOLIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CHEMISTRY; CHIRALITY; CRYSTALLIZATION; DIASTEREOISOMER; DRUG SYNTHESIS; GENERALIZED ANXIETY DISORDER; INSOMNIA; MICHAEL ADDITION; PLANT; PROTEIN QUATERNARY STRUCTURE; STEREOCHEMISTRY;

EID: 70349508830     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.08.119     Document Type: Article

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