Expeditious, large scale preparation of ethyl (R)-5-methyl-3-oxo octanoate via a cross Claisen reaction between N-acyl oxazolidinone derivatives and the magnesium enolate of potassium ethyl malonate

Tetrahedron Letters

Volumn 49, Issue 18, 2008, Pages 2956-2959

  Magano, Javier ^a   Nanninga, Thomas N ^b   Winkle, Derick D ^c  

^a PFIZER INC   (United States)

^b Bridge Organics   (United States)

^c Pleotint LLC   (United States)

Author keywords

Keto ester; Claisen; Magnesium enolate; Malonic acid ester; Oxazolidinone

Indexed keywords

BETA KETO ESTER; ESTER DERIVATIVE; ETHYL 5 METHYL 3 OXO OCTANOATE; LEWIS ACID; LITHIUM; MAGNESIUM; MAGNESIUM ENOLATE; MALONIC ACID; N ACYL OXAZOLIDINONE DERIVATIVE; OCTANOIC ACID; OXAZOLIDINONE DERIVATIVE; POTASSIUM ETHYL MALONATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE;

EID: 41349110825     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.03.004     Document Type: Article

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