Long-term outcomes of idiopathic membranous nephropathy in Japanese patients treated with low-dose cyclophosphamide and prednisolone

Nephrology Dialysis Transplantation

Volumn 24, Issue 10, 2009, Pages 3082-3088

  Eriguchi, Masahiro ^a   Oka, Hideaki ^a   Mizobuchi, Takeshi ^a   Kamimura, Taro ^a   Sugawara, Koji ^a   Harada, Atsumi ^a  

^a MATSUYAMA RED CROSS HOSPITAL   (Japan)

Author keywords

Idiopathic membranous nephropathy; Japanese patients; Low dose cyclophosphamide; Nephrotic syndrome; Renal prognosis

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN; METHYLPREDNISOLONE; MIZORIBINE; PREDNISOLONE;

ADULT; ALOPECIA; APHERESIS; ARTICLE; CAUCASIAN; CLINICAL TRIAL; COHORT ANALYSIS; COLITIS; COLON CANCER; CORTICOSTEROID THERAPY; CYSTITIS; CYTOMEGALOVIRUS INFECTION; DEATH; DRUG DOSE REDUCTION; ESOPHAGUS CANCER; FEMALE; HERPES ZOSTER; HUMAN; IDIOPATHIC MEMBRANOUS NEPHROPATHY; JAPANESE; KIDNEY DYSFUNCTION; KIDNEY FAILURE; LEUKOPENIA; LONG TERM CARE; LOW DRUG DOSE; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MEMBRANOUS GLOMERULONEPHRITIS; MENOPAUSE; MULTIVARIATE ANALYSIS; NEOPLASM; NEPHROTIC SYNDROME; PANCYTOPENIA; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROTEINURIA; RECTUM CANCER; REMISSION; RENAL DEATH; RESPIRATORY TRACT INFECTION; RISK FACTOR; SEPSIS; SIDE EFFECT; STOMACH CANCER; STOMACH ULCER; THYROID CANCER; TREATMENT FAILURE; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; CYCLOPHOSPHAMIDE; FEMALE; GLOMERULONEPHRITIS, MEMBRANOUS; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JAPAN; MALE; MIDDLE AGED; PREDNISOLONE; PROSPECTIVE STUDIES; TIME FACTORS; YOUNG ADULT;

EID: 70349487292     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp251     Document Type: Article

References (34)

1. SchieppatiA,MosconiL,PernaA et al.Prognosisofuntreated patients with idiopathic membranous nephropathy. N Engl J Med 1993; 329: 85-89
2. Ponticelli C, Zuchelli P, Passerini P et al. A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy. Kidney Int 1995; 48: 1600-1604
3. MacTier R, Boulton Jones JM, Payton CD et al. The natural history of membranous nephropathy in the west of Scotland. Q J Med 1986; 60: 793-802
4. Zuchelli P, Ponticelli C, Gagnoli P et al. Long-term outcome of idio-pathic membranous nephropathy with nephrotic syndrome. Nephrol Dial Transplant 1987; 2: 73-78
5. Donadio JV Jr, Torres VE, Velosa JA et al. Idiopathic membranous nephropathy: the natural historyofuntreated patients. Kidney Int 1988; 33: 708-715
6. Wehrmann M, Bohle A, Bogenschutz O et al. Long-term prognosis of chronic idiopathic membranous glomerulonephritis. An analysis of 334 cases with particular regard to tubulo-interstitial changes. Clin Nephrol 1989; 31: 67-76
7. Durin S, Barbanel C, Landais P et al. Long term course of idiopathic extramembranous glomerulonephritis. Study of predictive factors of terminal renal insufficiency in 82 untreated patients. Nephrologie 1990; 11: 67-71
8. du Buf-Vereijken PW, Branten AJ, Wetzels JF. Idiopathic membranous nephropathy: outline and rationale of a treatment strategy. Am J Kidney Dis 2005; 46:1012-1029
9. du Buf-Vereijken PW, Branten AJ, Wetzels JF. Membranous Nephropathy Study Group: cytotoxic therapy for membranous nephropathy and renal insufficiency; improved renal survival but high relapse rate. Nephrol Dial Transplant 2004; 19: 1142-1148
10. du Buf-Vereijken PW, Feith GW, Hollander D et al. Membranous Nephropathy Study Group: restrictive use of immunosuppressive treatment in patients with idiopathic membranous nephropathy: high renal survival in a large patient cohort. Q J Med 2004; 97: 353-360
11. Ponticelli C, Zucchelli P, Passerini P et al. A randomized trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy. N Engl J Med 1989; 320: 8-13
12. Ponticelli C, Zucchelli P, Passerini P et al. (the Italian Idiopathic Membranous Treatment Study Group). Methylprednisolone plus chloram-bucil versus methylprednisolone alone for the treatment of idiopathic membranous nephropathy. N Engl J Med 1992; 327: 599-603
13. Ponticelli C, Altieri P, Scolari F et al. A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J Am Soc Nephrol 1998; 9: 444-450
14. Jha V, Ganguli A, Saha TK et al. A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J Am Soc Nephrol 2007; 18: 1899-1904
15. Kida H, Asamoto T, Yokoyama H et al. Long-term prognosis of membranous nephropathy. Clin Nephrol 1986; 25: 64-69
16. Shiiki H, Saito T, Nishitani Y et al. Research Group on Progressive Renal Diseases in Japan. Prognosis and risk factors for idiopathic membranous nephropathy with nephritic syndrome in Japan. Kidney Int 2004; 65: 1400-1407
17. Japanese Society of Nephrology. Clinical practice guidelines for diagnosis and treatment of chronic kidney disease. Jpn J Nephrol 2007; 49: 755-870
18. Takaichi K, Takemoto F, Ubara Y et al. The clinically significant estimated glomerular filtration rate for hyperkalemia. Intern Med 2008; 47: 1315-1323
19. Reichert LJ, Koene RA, Wetzels JF. Prognostic factors in idiopathic membranous nephropathy. Am J Kidney Dis 1998; 31: 1-11
20. Cattran DC, Delmore T, Roscoe J et al. A randomized controlled trial of prednisone in patients with idiopathic membranous nephropathy. N Engl J Med 1989; 320: 210-215
21. Cameron JS, Healy MJ, Adu D (the MRC Glomerulonephritis Working Party). The Medical Research Council Trial of short-term high-dose alternate day prednisolone in idiopathic membranous nephropa-thy with nephrotic syndrome in adults. Q J Med 1990; 74: 133-156
22. Rastogi SP, Hart-Mercer J, Kerr DN. Idiopathic membranous glomerulonephritis in adults: remission following steroid therapy. Q J Med 1969; 38: 335-350
23. Branten AJ, Wetzels JF (for the Study Group). Short-and long-term efficacy of oral cyclophosphamide and steroids in patients with membranous nephropathy and renal insufficiency. Clin Nephrol 2001; 56: 1-9
24. Du Buf-Vereijken PW, Wetzels JF. Efficacy of a second course of im-munosuppressive therapy in patients with membranous nephropathy and persistent or relapsing disease activity. Nephrol Dial Transplant 2004; 19: 2036-2043
25. Wall RL, Clausen KP. Carcinoma of the urinary bladder in patients receiving cyclophosphamide. N Engl J Med 1975; 293: 271-273
26. Kinlen LJ, Sheil AGR, Peto J et al. Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppres-sive drugs. Br Med J 1979; 2: 1461-1466
27. Curtis RE, Boice JD Jr, Stovall M et al. Risk of leukemia after chemotherapy and radiation treatment for breast cancer. N Engl J Med 1992; 326: 1745-1751
28. Knight A, Askling J, Granath F et al. Urinary bladder cancer in We-gener's granulomatosis: risks and relation to cyclophosphamide. Ann Rheum Dis 2004; 63: 1307-1311
29. Travis LB, Curtis RE, Glimelius B et al. Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin's lymphoma. J Natl Cancer Inst 1995; 87: 524-530
30. The Research Group for Population-based Cancer Registration in Japan. Cancer incidence and incidence rates in Japan in 1999: estimates based in data from 11 population-based cancer registries. Jpn J Clin Oncol 2004; 34: 352-356
31. Complete life tables for 2005. Japanese Ministry of Health, Labour and Welfare. http://www.mhlw.go.jp/toukei/saikin/hw/life/20th/index.html. Accessed 10 July 2008.
32. Wakai S, Magil AB. Focal glomerulosclerosis in idiopathic membranous glomerulonephritis. Kidney Int 1992; 44: 428-434
33. Branten AJ, du Buf-Vereijken PW, Klasen IS et al. Urinary excretion of beta2-microglobulin and IgG predict prognosis in idiopathic membranous nephropathy: a validation study. J Am Soc Nephrol 2005; 16: 169-174
34. Cattran DC, Pei Y, Greenwood CM et al. Validation of a predictive model of idiopathic membranous nephropathy: its clinical and research implications. Kidney Int 1997; 51: 901-907