Efficacy of a second course of immunosuppressive therapy in patients with membranous nephropathy and persistent or relapsing disease activity

Nephrology Dialysis Transplantation

Volumn 19, Issue 8, 2004, Pages 2036-2043

  du Buf Vereijken P W G , Peggy ^a,b   Wetzels, Jack F M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b AMPHIA HOSPITAL   (Netherlands)

Author keywords

Chlorambucil; Cyclophosphamide; Immunosuppressive therapy; Membranous nephropathy; Relapse; Renal survival

Indexed keywords

AZATHIOPRINE; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; METHYLPREDNISOLONE; PREDNISONE;

ADULT; ANEMIA; ARTICLE; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; DIALYSIS; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; FOLLOW UP; HERPES ZOSTER; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FAILURE; KIDNEY FUNCTION; LEUKOPENIA; MALE; MEMBRANOUS GLOMERULONEPHRITIS; NAUSEA; NEPHROTIC SYNDROME; PRIORITY JOURNAL; PROTEINURIA; RECURRENT DISEASE; REMISSION; RESPIRATORY TRACT INFECTION; SURVIVAL RATE; THRUSH;

ADULT; AGED; CYCLOPHOSPHAMIDE; FEMALE; GLOMERULONEPHRITIS, MEMBRANOUS; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FUNCTION TESTS; LEUKOPENIA; MALE; MIDDLE AGED; PREDNISONE; RECURRENCE; RETREATMENT; TREATMENT OUTCOME;

EID: 4344666402     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh312     Document Type: Article

References (21)

1. Haas M, Meehan SM, Karrison TG, Spargo BH. Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997. Am J Kidney Dis 1997; 30: 621-631
2. Marx BE, Marx M. Prognosis of idiopathic membranous nephropathy: a methodologic meta-analysis. Kidney Int 1997; 51: 873-879
3. Ponticelli C, Zucchelli P, Passerini P et al. A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy. Kidney Int 1995; 48: 1600-1604
4. Cattran DC. Idiopathic membranous glomerulonephritis. Kidney Int 2001; 59: 1983-1994
5. Branten AJ, Reichert LJ, Koene RA, Wetzels JF. Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency. Q J Med 1998; 91: 359-366
6. Stirling CM, Simpson K, Boulton-Jones JM. Immunosuppression and outcome in idiopathic membranous nephropathy. Q J Med 1998; 91: 159-164
7. Torres A, Dominguez-Gil B, Carreno A et al. Conservative versus immurosuppressive treatment of patients with idiopathic membranous nephropathy. Kidney Int 2002; 61: 219-227
8. Du Buf-Vereijken PW, Branten AJ, Wetzels JF. Cytotoxic therapy for membranous nephropathy and renal insufficiency: improved renal survival but high relapse rate. Nephrol Dial Transplant 2004; 19: 1142-1148
9. Branten AJ, Wetzels JF. Short- and long-term efficacy of oral cyclophosphamide and steroids in patients with membranous nephropathy and renal insufficiency. Study Group. Clin Nephrol 2001; 56: 1-9
10. Ponticelli C, Passerini P, Altieri P, Locatelli F, Pappalettera M. Remissions and relapses in idiopathic membranous nephropathy. Nephrol Dial Transplant 1992; 7 [Suppl 1]: 85-90
11. Ponticelli C, Altieri P, Scolari F et al. A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J Am Soc Nephrol 1998; 9: 444-450
12. Laluck BJ, Jr, Cattran DC. Prognosis after a complete remission in adult patients with idiopathic membranous nephropathy. Am J Kidney Dis 1999; 33: 1026-1032
13. Jindal K, West M, Bear R, Goldstein M. Long-term benefits of therapy with cyclophosphamide and prednisone in patients with membranous glomerulonephritis and impaired renal function. Am J Kidney Dis 1992; 19: 61-67
14. Faedda R, Satta A, Bosincu L, Pirisi M, Bartoli E. Immunosuppressive treatment of membranous glomerulonephritis. J Nephrol 1995; 8: 107-112
15. Suki WN, Trimarchi H, Frommer JP. Relapsing membranous nephropathy. Response to therapy of relapses compared to that of the original disease. Am J Nephrol 1999; 19: 474-479
16. Du Buf-Vereijken PW, Feith GW, Hollander D et al. Restrictive use of immunosuppressive treatment in patients with idiopathic membranous nephropathy: high renal survival in a large patient cohort. Q J Med 2004; 97 (in press)
17. Talar-Williams C, Hijazi YM, Walther MM et al. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis. Ann Intern Med 1996; 124: 477-484
18. Knight A, Askling J, Ekbom A. Cancer incidence in a population-based cohort of patients with Wegener's granulomatosis. Int J Cancer 2002; 100: 82-85
19. Cattran DC, Greenwood C, Ritchie S et al. A controlled trial of cyclosporine in patients with progressive membranous nephropathy. Canadian Glomerulonephritis Study Group. Kidney Int 1995; 47: 1130-1135
20. Rostoker G, Belghiti D, Ben Maadi A et al. Long-term cyclosporin A therapy for severe idiopathic membranous nephropathy. Nephron 1993; 63: 335-341
21. Fritsche L, Budde K, Farber L et al. Treatment of membranous glomerulopathy with cyclosporin A: how much patience is required? Nephrol Dial Transplant 1999; 14: 1036-1038