Predicting age-specific dosing of antipsychotics

Clinical Pharmacology and Therapeutics

Volumn 86, Issue 4, 2009, Pages 360-362

  Uchida, H ^a,b   Pollock, B G ^a,c,d   Bies, R R ^a,e   Mamo, D C ^a,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

^d ROTMAN RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE RECEPTOR; NEUROLEPTIC AGENT; PALIPERIDONE; RACLOPRIDE C 11; RISPERIDONE;

AGE DISTRIBUTION; AGING; AUDITORY HALLUCINATION; COMORBIDITY; DELUSION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; DRUG TOLERABILITY; EXTRAPYRAMIDAL SYMPTOM; HUMAN; LIFESPAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SCHIZOPHRENIA; TREATMENT RESPONSE;

AGING; ANTIPSYCHOTIC AGENTS; BASAL GANGLIA DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, DOPAMINE; SCHIZOPHRENIA;

EID: 70349451390     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.133     Document Type: Review

References (5)

1. Uchida, H., Mamo, D.C., Mulsant, B.H., Pollock, B.G. & Kapur, S. Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms. J. Clin. Psychiatry 70, 397-405 (2009).
2. Feng, Y. et al. Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study. Br. J. Clin. Pharmacol. 66, 629-639 (2008).
3. Uchida, H., Kapur, S., Mulsant, B.H., Graff-Guerrero, A., Pollock, B.G. & Mamo, D.C. Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. Am. J. Geriatr. Psychiatry 17, 255-263 (2009).
4. Uchida, H. et al. Effects of age and age of onset on prescribed antipsychotic dose in schizophrenia spectrum disorders: a survey of 1,418 patients in Japan. Am. J. Geriatr. Psychiatry 16, 584-593 (2008).
5. Mamo, D.C., Sweet, R.A., Chengappa, K.N., Reddy, R.R. & Jeste, D.V. The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders. Int. J. Geriatr. Psychiatry 17, 1012-1017 (2002).