Triggered release of small molecules from proteinoid microspheres

Journal of Biomedical Materials Research - Part A

Volumn 91, Issue 2, 2009, Pages 391-399

  Quirk, Stephen ^a  

^a KIMBERLY CLARK CORPORATION   (United States)

Author keywords

Controlled release; Drug delivery; Fluorescence assay; Thermal condensation; Vessicle

Indexed keywords

BIOCHEMICAL REACTIONS; BREAKDOWN PRODUCTS; CONTROLLED DELIVERY; CONTROLLED RELEASE; DELIVERY VEHICLE; EVOLUTIONARY THEORIES; FLUORESCENCE ASSAY; INTERIOR MATERIALS; INTERIOR SPACE; MOLECULAR BRIDGING; ORGANIC SMALL MOLECULE; REDUCING ENVIRONMENT; REDUCTION POTENTIAL; SMALL MOLECULES; THERMAL CONDENSATION; TRIGGERED RELEASE; VESSICLE;

AMINATION; AMINES; AMINO ACIDS; CONDENSATION; FLUORESCENCE; MICROSPHERES; ORGANIC ACIDS; PERMANENT MAGNETS; WINDOWS;

CONTROLLED DRUG DELIVERY;

MICROSPHERE; PROTEINOID MICROSPHERE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLUORESCENCE ANALYSIS; HUMAN; POLYMERIZATION; TEMPERATURE DEPENDENCE;

AMINO ACIDS; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; TEMPERATURE;

EID: 70349439025     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32241     Document Type: Article

References (41)

1. Harada K, Fox SW. The thermal condensation of glutamic acid and glycine to linear peptides. J Am Chem Soc 1958;80:2694-2697.
2. Harada K, Fox SW. The thermal copolymerization of aspartic acid and glutamic acid. Arch Biochem Biophys 1960;86:274-280.
3. Fox SW, Harada K. The thermal copolymerization of amino acids common to protein. J Am Chem Soc 1960;82:3745-3751.
4. Fox SW. Thermal polymerization of amino acids and production of formed microparticles on lava. Nature 1964;201:336-337.
5. Fox SW, Jungck JR, Nakashima T. From proteinoid microsphere to contemporary cell: Formation of internucleotide and peptide bonds by proteinoid particles. Orig Life 1974;5:227-237.
6. Fox SW. The evolutionary significance of phase-separated microsystems. Orig Life 1976;7:49-68.
7. Fox SW. Synthesis of life in the lab? Defining a protoliving system. Q Rev Biol 1991;66:181-185.
8. McAlhaney WW, Rohlfing DL. Formation of proteinoid microspheres under simulated prebiotic atmospheres and individual gases. Biosystems 1976;8:45-50.
9. Snyder WD, Fox SW. A model for the origin of stable protocells in a primitive alkaline ocean. Biosystems 1975;7:222-229.
10. Rohlfing DL. Coacervate-like microspheres from lysine-rich proteinoid. Orig Life 1975;6:203-209.
11. Berger G. Hypotheses on the establishment of a genetic code and transfer of information from proteinoids to nucleic acids. C R Acad Sci III 1984;299:333-338. (Pubitemid 14019230)
12. Matsuno K. Self-sustaining multiplication and reproduction of microsystems in protobiogenesis. Biosystems 1981;14:163-170. (Pubitemid 12251923)
13. Fox SW. Self-sequencing of amino acids and origins of polyfunctional protocells. Orig Life 1984;14:485-488.
14. Brooke S, Fox SW. Compartmentalization in proteinoid microspheres. Biosystems 1977;9:1-22.
15. Hsu LL, Brooke S, Fox SW. Conjugation of proteinoid microspheres: A model of primordial communication. Curr Mod Biol 1971;4:12-25.
16. Hsu LL, Fox SW. Interactions between diverse proteinoids and microspheres in simulation of primordial evolution. Biosystems 1976;8:89-101.
17. Nakashima T, Fox SW. Synthesis of peptides from amino acids and ATP with lysine-rich proteinoid. J Mol Evol 1980;15:161-168.
18. Fox SW, Nakashima T. The assembly and properties of protobiological structures: The beginnings of cellular peptide synthesis. Biosystems 1980;12:155-166. (Pubitemid 10002153)
19. Ryan JW, Fox SW. Activation of glycine by ATP, a divalent cation, and proteinoid microspheres. Curr Mod Biol 1973;5:115-118.
20. Jungck JR, Fox SW. Synthesis of oligonucleotides by proteinoid microspheres acting on ATP. Naturwissenschaften 1973;60:425-427.
21. Masinovsky Z, Lozovaya GI, Sivash AA, Drasner M. Porphyrin-proteinoid complexes as models of prebiotic photosensitizers. Biosystems 1989;22:305-310.
22. Masinovsky Z. The origin and early development of biological catalysts. Cas Lek Cesk 1995;134:607-610.
23. Hartmann J, Brand MC, Dose K. Formation of specific amino acid sequences during thermal polymerization of amino acids. Biosystems 1981;13:141-147.
24. Muller-Herold U, Nickel G. The stability of proteinoid microspheres. Biosystems 1994;33:215-220.
25. Syren RM, Sanjur A, Fox SW. Proteinoid microspheres more stable in hot than in cold water. Biosystems 1985;17:275-280. (Pubitemid 16228206)
26. Fox SW, Nakashima T. Fractionation and characterization of an amidated thermal 1:1:1 proteinoid. Biochim Biophys Acta 1974;140:155-167.
27. Phillips RD, Melius P. The thermal polymerization of amino acids. Int J Pept Protein Res 1974;6:309-319.
28. Luque-Romero MM, de Medina LS, Blanco JM. Fractionation and amino acid composition of an aspartic acid-containing thermal proteinoid population. Biosystems 1986;19:267-272.
29. Kokufuta E, Sakai H, Harada K. Factors controlling the size of proteinoid microspheres. Biosystems 1983;16:175-181.
30. Matsuno K. Material self-assembly as a physiochemical process. Biosystems 1981;13:237-241.
31. Matsuno K. Electrical excitability of proteinoid microspheres composed of basic and acidic proteinoids. Biosystems 1984;17:11-14. (Pubitemid 14063628)
32. Przybylski AT. Excitable cell made of thermal proteinoids. Biosystems 1985;17:281-288.
33. Przybylski AT, Stratten WP, Syren RM, Fox SW. Membrane, action, and oscillatory potentials in simulated protocells. Naturwissenschaften 1982;69:561-563.
34. Ishima Y, Przybylski AT, Fox SW. Electrical membrane phenomena in spherules from proteinoid and lecithin. Biosystems 1981;13:243-251. (Pubitemid 11039052)
35. Ma X, Santiago N, Chen YS, Chaudhary K, Milstein SJ, Baughman RA. Stability study of drug-loaded proteinoid microsphere formulations during freeze-drying. J Drug Target 1994;2:9-21. (Pubitemid 24106956)
36. Santiago N, Milstein S, Rivera T, Garcia E, Zaidi T, Hong H, Bucher D. Oral immunization of rats with proteinoid microspheres encapsulating influenza virus antigens. Pharm Res 1993;10:1243-1247. (Pubitemid 23244185)
37. Madhan Kumar AB, Panduranga Rao K. Preparation and characterization of pH-sensitive proteinoid microspheres for the oral delivery of methotrexate. Biomaterials 1998;19:725-732. (Pubitemid 28276622)
38. Green NS, Reisler E, Houk KN. Quantitative evaluation of the lengths of homobifunctional protein cross-inking reagents used as molecular probes. Prot Sci 2001;10:1293-1304. (Pubitemid 32568096)
39. Lakowicz JR. Principles of Fluorescence Spectroscopy. New York: Plenum Press; 1983. Chapter 10.
40. Kiyota T, Lee S, Sugihara G. Design and synthesis of amphiphilic alpha helical model peptides with systematically varied hydrophobic-hydrophilic balance and their interaction with lipid- and bio-membranes. Biochemistry 1996;35:13196-13204. (Pubitemid 26349472)
41. Bae SK, Kim JD. Aggregation behaviors and their pH sensitivity of cholesterol conjugated proteinoids composed of glutamic acid and aspartic acid matrix. J Biomed Mater Res A 2003;64:282-290.