Preparation and characterization of pH-sensitive proteinoid microspheres for the oral delivery of methotrexate

Biomaterials

Volumn 19, Issue 7-9, 1998, Pages 725-732

  Madhan Kumar, A B ^a   Panduranga Rao, K ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

Amino acids; Drug delivery; Methotrexate; Microspheres; Proteinoid; Self assembly

Indexed keywords

AMINO ACIDS; BLOOD; CONFORMATIONS; CONTROLLED DRUG DELIVERY; DISSOLUTION; MORPHOLOGY; OPTICAL MICROSCOPY; PH EFFECTS; SCANNING ELECTRON MICROSCOPY; SYNTHESIS (CHEMICAL);

METHOTREXATE; POLYPEPTIDE; PROTEINOID;

BIOMATERIALS;

METHOTREXATE; MICROSPHERE; POLYPEPTIDE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; MICROSCOPY; ORAL DRUG ADMINISTRATION; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

ADMINISTRATION, ORAL; ANTIMETABOLITES, ANTINEOPLASTIC; BUFFERS; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; HYDROGEN-ION CONCENTRATION; METHOTREXATE; MICROSPHERES; PARTICLE SIZE; PROTEINS;

EID: 0032053116     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(97)00188-9     Document Type: Article

References (26)

1. [1] Forni F, Maria AV, Riccardo C. Influence of drug loading level on drug release and dynamic swelling of crosslinked gelatin microspheres. J Microencapsulation 1992;9:29-39.
2. [2] Jayakrishnan A, Knepp WA, Goldberg EP. Casein microspheres: preparation and evaluation as a carrier for controlled drug delivery. Int J Pharm 1994;106:221-28.
3. [3] Chithambara Thanoo B, Sunny MC, Jayakrishnan A. Crosslinked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J Pharm Pharmacol 1992;44:283-86.
4. [4] Levy MC, Andry MC. Mixed walled microcapsules made of cross-linked proteins and polysaccharides: preparation and properties. J Microencapsulation 1991;8:335-47.
5. [5] Wan LSC, Heng PWS, Chan LW. Drug encapsulation in alginate microspheres by emulsification. J Microencapsulation 1992; 9:309-16.
6. [6] Cohen S, Lobel E, Goda AT, Peled Y. A novel in situ-forming opthalmic drug delivery system from alginates undergoing gelation in the eye. J Controlled Release 1997;44:201-8.
7. [7] Wan LSC, Heng PWS, Chan LW. Surfactant effects on alginate microspheres. Int J Pharm 1994;103:267-75.
8. [8] Schepky G, Busch V, Heinzel G, Josk K, Lechner V, Mielenz H, Su CA. Influence of enteric coating on drug delivery and absorption of fusidic acid film-coated tablets. Pharm Ind 1991;53:1135-39.
9. [9] Lin SX, Tzan YL, Lee CJ, Weng CN. Preparation of enteric coated microspheres of mycoplasma hyopneumoniae vaccine with cellulose acetate phthalate. Formation condition and micromeritic properties. J Microencapsulation 1991;8:311-25.
10. [10] Fox SW. How did life begin? Science 1960;132:200-8.
11. [11] Madhan Kumar AB, Jayakumar R, Panduranga Rao K. Synthesis and aggregational behavior of acidic proteinoid. J Polym Sci Polym Chem 1996;34:2915-24.
12. [12] Bodmeir R, Chen H, Paeratakul O. A novel approach to the oral delivery of micro or nanoparticles. Pharm Res 1989;6:413-17.
13. [13] Bertino JR. Folate antagonists. In: Sonotelli AC, Johns DG, editors. Antineoplastic and immunosuppressive agents. Berlin: Springer, 1975:408.
14. [14] Siggia S, Hanna JG. Quantitative organic analysis via functioinal groups. 4th edn. New York: John Wiley & Sons, 1979:164-65.
15. [15] Greenfield N, Fasman GD. Computed circular Dichroism spectra for the evaluation of protein conformation. Biochemistry 1969;8:4108-16.
16. [16] Woody RW. Optical rotatory properties of biopolymers. J Polym Sci Macromol Rev 1977;12:181-90.
17. [17] Steiner S, Rosen R. Delivery systems for pharmacological agents encapsulated with proteinoids. US Patent No. 4, 925, 673, 15 May 1990.
18. [18] Fox SW, Harada K. The thermal copolymerization of amino acids common to protein. J Am Chem Soc 1960;82:3745-51.
19. [19] Marck KW, Wildevuar ChRH, Sederal WL, Bantjes A, Feijen J. Biodegradability and tissue reaction of random copolymers of L-leucine, L-aspartic acid and L-aspartic acid esters. J Biomed Mater Res 1977;11:405-22.
20. [20] Martin EC, May PD, McMahon WA. Amino acid polymers for biomedical applications. I. Permeability properties of L-leucine and DL-methionine copolymers. J Biomed Mater Res 1971;5:53-62.
21. [21] Biji A, Cojazzi G, Roveri N, Koch MHJ. Differential scanning calorimetry and X-ray diffraction study of tendon collagen thermal denaturation. Int J Biol Macromol 1987;9:363-67.
22. [22] Loke WK, Khor E. Validation of the shrinkage temperature of animal tissue for bioprosthetic heart valve application by differential scanning calorimetry. Biomaterials 1995;16:251-58.
23. a shifts: Implications for efficiency of conversion to chemical energy. J Am Chem Soc 1995;117:8478-79.
24. [24] Clerc JT, Pretsch E, Seibl J. Structural analysis of organic compounds by combined application of spectroscopic methods. vol. 1. Amsterdam: Elsevier Scientific Publishing Co., 1981:22.
25. [25] Santiago N, Milstein S, Rivera T, Garcia E, Zaidi T, Hong H, Bucher D. Oral immunization of rats with proteinoid microspheres encapsulating influenza virus Antigens. Pharm Res 1993;8:1243-47.
26. [26] Smith PL, Wall DA, Gochoco CH, Wilson G. Oral absorption of peptides and proteins. Adv Drug Delivery Rev 1992;8:253-90.