Clinical and human leucocyte antigen class II haplotype associations of autoantibodies to small ubiquitin-like modifier enzyme, a dermatomyositis- specific autoantigen target, in UK Caucasian adult-onset myositis

Annals of the Rheumatic Diseases

Volumn 68, Issue 10, 2009, Pages 1621-1625

  Betteridge, Z E ^a   Gunawardena, H ^a,b   Chinoy, H ^c   North, J ^a   Ollier, W E R ^c   Cooper, R G ^c   McHugh, N J ^a,b  

^a University of Bath   (United Kingdom)

^b ROYAL NATIONAL HOSPITAL FOR RHEUMATIC DISEASES   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DNA; HLA ANTIGEN CLASS 2; SMALL UBIQUITIN LIKE MODIFIER ACTIVATING ENZYME AUTOANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; CAUCASIAN; CLINICAL FEATURE; CONTROLLED STUDY; DERMATOMYOSITIS; DNA DETERMINATION; DYSPHAGIA; FEMALE; GENE FREQUENCY; GENE LOCATION; GENETIC ASSOCIATION; GENETIC RISK; GENOME ANALYSIS; HAPLOTYPE; HUMAN; HUMAN CELL; IMMUNOGENICITY; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; RADIOIMMUNOPRECIPITATION; UNITED KINGDOM;

AGED; AUTOANTIBODIES; AUTOANTIGENS; COHORT STUDIES; DERMATOMYOSITIS; FEMALE; GREAT BRITAIN; HAPLOTYPES; HISTOCOMPATIBILITY TESTING; HLA-D ANTIGENS; HUMANS; MALE; MIDDLE AGED; MYOSITIS; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS;

EID: 70349398823     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2008.097162     Document Type: Article

References (29)

1. Mimori T, Imura Y, Nakashima R, et al. Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance. Curr Opin Rheum 2007;19:523-529 (Pubitemid 47530870)
2. Hirakata M. Autoantibodies to aminoacyl-tRNA synthetases. Intern Med 2005;44:527-528
3. Hengstman GJ, ter Laak HJ, Vree Egberts WT, et al. Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis 2006;65:1635.
4. Ghirardello A, Zampieri S, Iaccarino L, et al. Anti-Mi-2 antibodies. Autoimmunity 2005;38:79-83.
5. Targoff IN, Mamyrova G, Trieu EP,et al. A novel autoantibody to a 155-kd protein is associated with dermatomyositis. Arthritis Rheum 2006;54:3682-3689
6. Chinoy H, Fertig N, Oddis CV, et al. The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis. Ann Rheum Dis 2007;66:1345-1349 (Pubitemid 47492479)
7. Kaji K, Fujimoto M, Hasegawa M, et al. Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy. Rheumatology (Oxford) 2007;46:25-28 (Pubitemid 44932779)
8. Gunawardena H, Wedderburn L, North J, et al. Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis. Rheumatology (Oxford) 2008;47:324-328 (Pubitemid 351267200)
9. Chinoy H, Salway F, Fertig N, et al. In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. Arthritis Res Ther 2006;8:R13.
10. Betteridge Z, Gunawardena H, North J, et al. Identification of a novel autoantibody directed against small ubiquitin-like modifier activating enzyme in dermatomyositis. Arthritis Rheum 2007;56:3132-3137 (Pubitemid 47502761)
11. Bohan A, Peter JB. Polymyositis and dermatomyositis (part 1). N Engl J Med 1975;292:344-347
12. Bohan A, Peter JB. Polymyositis and dermatomyositis (part 2). N Engl J Med 1975;292:403-407
13. Betteridge Z, Gunawardena H, North J, et al. Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia. Rheumatology 2007;46:1005-1008 (Pubitemid 47062512)
14. Doherty DG, Vaughan RW, Donaldson PT, et al. HLA DQA, DQB, and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British caucasoids. Hum Immunol 1992;34:53-63.
15. Targoff IN, Trieu EP, Levy-Neto M, et al. Autoantibodies to transcriptional intermediary factor 1-gamma (TIF1-g) in dermatomyositis. Arthritis Rheum 2006;54:S518.
16. Sato S, Hirakata M, Kuwana M, et al. Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum 2005;52:1571-1576 (Pubitemid 40663949)
17. Wedderburn LR, McHugh NJ, Chinoy H, et al. HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. Rheumatology 2007;46:1786-1791 (Pubitemid 350176276)
18. Wang HB, Zhang Y. Mi2, an autoantigen for dermatomyositis, is an ATP-dependant nucleosome remodeling factor. Nucleic Acid Res 2001;29:2517-2521 (Pubitemid 32600307)
19. Yan KP, Dollé P, Mark M, et al. Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene. Gene 2004;334:3-13. (Pubitemid 38902710)
20. Gill G. SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev 2004;18:2046-2059
21. Dohmen RJ. SUMO protein modification. Biochim Biophys Acta 2004;1695:113-131
22. Pichler A, Melchior F. Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport. Traffic 2002;3:381-387 (Pubitemid 34746405)
23. Hemelaar J, Borodovsky A, Kessler BM, et al. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol 2004;24:84-95. (Pubitemid 38010037)
24. Gong Z, Brackertz M, Renkawitz. SUMO modification enhances p66-mediated transcriptional repression of the Mi-2/NuRD complex. Mol Cell Biol 2006;26:4519-4528
25. Oddis CV, Fertig N, Goel A, et al. Clinical and serological characterization of the anti- MJ antibody in childhood myositis. Arthritis Rheum 1997;40:S139.
26. Targoff IN, Trieu EP, Levy-Neto M, et al. Sera with Autoantibodies to the MJ antigen react with NXP2. Arthritis Rheum 2007;56:S787.
27. Rosendorff A, Sakakibara S, Lu S, et al. NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci USA 2006;103:5308-5313
28. Casciola-Rosen L, Nagaraju K, Plotz P, et al. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 2005;201:591-601. (Pubitemid 40289549)
29. Levine SM, Raben N, Xie D, et al. Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis. Arthritis Rheum 2007;56:2729-2739 (Pubitemid 47237292)