Altered Na+ transport after an intracellular α-subunit deletion reveals strict external sequential release of Na+ from the Na/K pump

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 36, 2009, Pages 15507-15512

  Yaragatupalli, Siddhartha ^a   Fernando Olivera, J ^a   Gatto, Craig ^b   Artigas, Pablo ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b ILLINOIS STATE UNIVERSITY   (United States)

Author keywords

C terminal truncation; Ion access channel; Ion binding; Na,K ATPase; Voltage dependence

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); GUANIDINE; POTASSIUM ION; SODIUM ION;

ALPHA CHAIN; ARTICLE; BINDING AFFINITY; BINDING SITE; ELECTRIC POTENTIAL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SODIUM TRANSPORT; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ELECTROPHYSIOLOGY; GENE DELETION; GUANIDINE; ION TRANSPORT; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; SODIUM; SODIUM-POTASSIUM-EXCHANGING ATPASE; XENOPUS;

ANIMALIA;

EID: 70349349159     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903752106     Document Type: Article

References (35)

1. Post RL, Sen AK, Rosenthal AS (1965) A phosphorylated intermediate in adenosine triphosphate-dependent sodium and potassium transport across kidney membranes. J Biol Chem 240:1437-1445.
2. Albers RW (1967) Biochemical aspects of active transport. Annu Rev Biochem 36:727-756.
3. Morth JP, et al. (2007) Crystal structure of the sodium-potassium pump. Nature 450:1043-1049.
4. Geering K, et al. (2003) FXYD proteins: New tissue- and isoform-specific regulators of Na,K-ATPase. Ann NY Acad Sci 986:388-394. (Pubitemid 36584139)
5. +-ATPase. Proc Natl Acad Sci USA 99:15977-15982.
6. +-binding site in the sodium pump. Proc Natl Acad Sci USA 102:12706-12711.
7. Peluffo RD, Berlin JR (1997) Electrogenic K+ transport by the Na(+)-K+ pump in rat cardiac ventricular myocytes. J Physiol 501(Pt 1):33-40.
8. Gadsby DC, Rakowski RF, De Weer P (1993) Extracellular access to the Na,K pump: Pathway similar to ion channel. Science 260:100-103. (Pubitemid 23122754)
9. Sagar A, Rakowski RF (1994) Access channel model for the voltage dependence of the forward-running Na+/K+ pump. J Gen Physiol 103:869-893.
10. Heyse S, Wuddel I, Apell HJ, Sturmer W (1994) Partial reactions of the Na,K-ATPase: Determination of rate constants. J Gen Physiol 104:197-240. (Pubitemid 24262238)
11. +-ATPase. Nature 403:898-901.
12. +]. J Membr Biol 121:177-187.
13. Nakao M, Gadsby DC (1989) [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes. J Gen Physiol 94:539-565. (Pubitemid 19235797)
14. Nakao M. Gadsby DC (1986) Voltage dependence of Na translocation by the Na/K pump. Nature 323:628-630. (Pubitemid 16008555)
15. Hilgemann DW (1994) Channel-like function of the Na,K pump probed at microsecond resolution in giant membrane patches. Science 263:1429-1432.
16. Holmgren M, Rakowski RF (2006) Charge translocation by the Na+/K+ pump under Na+/Na+ exchange conditions: Intracellular Na+ dependence. Biophys J 90:1607-1616.
17. Schneeberger A, Apell HJ (2001) Ion selectivity of the cytoplasmic binding sites of the Na,K-ATPase: II. Competition of various cations. J Membr Biol 179:263-273. (Pubitemid 32165799)
18. Apell HJ, Karlish SJ (2001) Functional properties of Na,K-ATPase, and their structural implications, as detected with biophysical techniques. J Membr Biol 180:1-9.
19. Wang X, Horisberger JD (1995) A conformation of Na(+)-K+ pump is permeable to proton. Am J Physiol 268:C590-595.
20. Rettinger J (1996) Characteristics of Na+/K(+)-ATPase mediated proton current in Na(+)- and K(+)-free extracellular solutions. Indications for kinetic similarities between H+/K(+)-ATPase and Na+/K(+)-ATPase. Biochim Biophys Acta 1282:207-215.
21. Li C, Geering K, Horisberger JD (2006) The third sodium binding site of Na,K-ATPase is functionally linked to acidic pH-activated inward current. J Membr Biol 213:1-9. (Pubitemid 46440138)
22. Vasilyev A, Khater K, Rakowski RF (2004) Effect of extracellular pH on presteady-state and steady-state current mediated by the Na+/K+ pump. J Membr Biol 198:65-76. (Pubitemid 38581014)
23. Gatto C, et al. (2006) Similarities and differences between organic cation inhibition of the Na,K-ATPase and PMCA. Biochemistry 45:13331-13345. (Pubitemid 44707693)
24. Hille B (1971) The permeability of the sodium channel to organic cations in myelinated nerve. J Gen Physiol 58:599-619.
25. Kellenberger S, et al. (2001) Permeability properties of ENaC selectivity filter mutants. J Gen Physiol 118:679-692. (Pubitemid 33131100)
26. Morth JP, et al. (2009) The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations. Philos Trans R Soc Lond Ser B 364:217-227.
27. Pietrobon D (2007) Familial hemiplegic migraine. Neurotherapeutics 4:274-284.
28. Tavraz NN et al. (2008) Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. J Biol Chem 283:31097-31106.
29. Koenderink JB, et al. (2003) Electrophysiological analysis of the mutated Na,K-ATPase cation binding pocket. J Biol Chem 278:51213-51222.
30. Peluffo RD, Hara Y, Berlin JR (2004) Quaternary organic amines inhibit Na,K pump current in a voltage-dependent manner: Direct evidence of an extracellular access channel in the Na,K-ATPase. J Gen Physiol 123:249-263. (Pubitemid 38282974)
31. Nutter TJ, Adams DJ (1995) Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia. J Gen Physiol 105:701-723.
32. Villarroel A, Burnashev N, Sakmann B (1995) Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys J 68:866-875.
33. Artigas P, Gadsby DC (2004) Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands. J Gen Physiol 123:357-376. (Pubitemid 38469280)
34. Takeuchi A, Reyes N, Artigas P, Gadsby DC (2008) The ion pathway through the opened Na(+),K(+)-ATPase pump. Nature 456:413-416.
35. 935. J Biol Chem 284:18715-18725.