Auditioning of CHO host cell lines using the artificial chromosome expression (ACE) technology

Biotechnology and Bioengineering

Volumn 104, Issue 3, 2009, Pages 526-539

  Kennard, Malcolm L ^a   Goosney, Danika L ^b   Monteith, Diane ^c   Roe, Susanna ^d   Fischer, David ^d   Mott, John ^d  

^a Kennard Biologic Consultants   (Canada)

^b CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

^c Centre for Drug Research and Development   (Canada)

^d PFIZER INC   (United States)

Author keywords

ACE; CHO; MAb; Protein expression

Indexed keywords

ACCEPTOR SITES; ACE; ANTIBODY EXPRESSION; ARTIFICIAL CHROMOSOMES; CELL LINES; CELL PHENOTYPE; CHO; CHO CELL; CULTURE CONDITIONS; GENE COPY NUMBER; GENE LOCATION; GENETIC FACTORS; HOST CELLS; KEY FEATURE; MAB; MAMMALIAN CELLS; PROTEIN EXPRESSION; PROTEIN EXPRESSIONS; RECOMBINANT PROTEIN EXPRESSION; SCREENING TECHNIQUES; TRANSFECTION METHODS; VECTOR CONSTRUCTION; WHETHER DIFFERENCES;

ANIMAL CELL CULTURE; AUDITION; CELL MEMBRANES; CHROMOSOMES; MAMMALS; MONOCLONAL ANTIBODIES; NUCLEIC ACIDS; PROTEINS;

CELL CULTURE;

IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; ARTIFICIAL CHROMOSOME; BIOTECHNOLOGY; CELL CLONE; CHO CELL; GENE LOCATION; GENETIC RECOMBINATION; GENETIC TRANSFECTION; GENOME; HOST CELL; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PURIFICATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMOSOMES, ARTIFICIAL; CRICETINAE; CRICETULUS; GENE EXPRESSION; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN G; RECOMBINANT PROTEINS; TRANSFECTION;

MAMMALIA;

EID: 70349338828     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22407     Document Type: Article

References (12)

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