Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4

FASEB Journal

Volumn 23, Issue 5, 2009, Pages 1405-1414

  Dien Bard, J ^a   Gelebart, P ^a   Amin, H M ^b   Young, L C ^a   Ma, Y ^c   Lai, R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Department of Hematology Oncology   (United States)

Author keywords

Cell signaling; Chromatin immunoprecipitation; Luciferase assay

Indexed keywords

LUCIFERASE; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SALL4; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; BREAST CELL; BREAST TUMOR; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SITE DIRECTED MUTAGENESIS; UPREGULATION; WESTERN BLOTTING;

BASE SEQUENCE; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; DOWN-REGULATION; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS, GENETIC; STAT3 TRANSCRIPTION FACTOR; TETRACYCLINE; TRANSCRIPTION FACTORS;

EID: 70349336784     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-117721     Document Type: Article

References (44)

1. Clevenger, C. V. (2004) Roles and regulation of Stat family transcription factors in human breast cancer. Am. J. Pathol. 165, 1449-1460
2. Yu, H., and Jove, R. (2004) The STATs of cancer - new molecular targets come of age. Nat. Rev. Cancer 4, 97-105 (Pubitemid 38198738)
3. Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro-Cacho, C. A., Cox, C. E., Falcone, R., Fairclough, R., Parsons, S., Laudano, A., Gazit, A., Levitzki, A., Kraker, A., and Jove, R. (2001) Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 20, 2499-2513 (Pubitemid 32531347)
4. Scholz, A., Heinze, S., Detjen, K. M., Peters, M., Welzel, M., Hauff, P., Schirner, M., Wiedenmann, B., and Rosewicz, S. (2003) Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 125, 891-905 (Pubitemid 37070705)
5. Zamo, A., Chiarle, R., Piva, R., Howes, J., Fan, Y., Chilosi, M., Levy, D. E., and Inghirami, G. (2002) Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 21, 1038-1047 (Pubitemid 34174516)
6. Bowman, T., Garcia, R., Turkson, J., and Jove, R. (2000) STATs in oncogenesis. Oncogene 19, 2474-2488
7. Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., and Darnell, J. E., Jr. (1999) Stat3 as an oncogene. Cell 98, 295-303
8. Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., and Akira, S. (1997) Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. U. S. A. 94, 3801-3804 (Pubitemid 27180453)
9. Boeuf, H., Hauss, C., Graeve, F. D., Baran, N., and Kedinger, C. (1997) Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J. Cell Biol. 138, 1207-1217 (Pubitemid 27415048)
10. Niwa, H., Burdon, T., Chambers, I., and Smith, A. (1998) Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 12, 2048-2060 (Pubitemid 28323878)
11. Raz, R., Lee, C. K., Cannizzaro, L. A., d'Eustachio, P., and Levy, D. E. (1999) Essential role of STAT3 for embryonic stem cell pluripotency. Proc. Natl. Acad. Sci. U. S. A. 96, 2846-2851
12. Evans, M. J., and Kaufman, M. H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156 (Pubitemid 11050741)
13. Martin, G. R. (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. U. S. A. 78, 7634-7638
14. Skinnider, B. F., Connors, J. M., Sutcliffe, S. B., and Gascoyne, R. D. (1999) Anaplastic large cell lymphoma: a clinicopathologic analysis. Hematol. Oncol. 17, 137-148 (Pubitemid 30180098)
15. Gearing, D. P., Thut, C. J., VandeBos, T., Gimpel, S. D., Delaney, P. B., King, J., Price, V., Cosman, D., and Beckmann, M. P. (1991) Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 10, 2839-2848 (Pubitemid 21905301)
16. Smith, A. G., Heath, J. K., Donaldson, D. D., Wong, G. G., Moreau, J., Stahl, M., and Rogers, D. (1988) Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336, 688-690 (Pubitemid 19007952)
17. Chambers, I., and Smith, A. (2004) Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 23, 7150-7160 (Pubitemid 39382149)
18. Niwa, H. (2001) Molecular mechanism to maintain stem cell renewal of ES cells. Cell Struct. Funct. 26, 137-148
19. Niwa, H., Miyazaki, J., and Smith, A. G. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24, 372-376 (Pubitemid 30187435)
20. Vernallis, A. B., Hudson, K. R., and Heath, J. K. (1997) An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M. J. Biol. Chem. 272, 26947-26952
21. Al-Baradie, R., Yamada, K., St Hilaire, C., Chan, W. M., Andrews, C., McIntosh, N., Nakano, M., Martonyi, E. J., Raymond, W. R., Okumura, S., Okihiro, M. M., and Engle, E. C. (2002) Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Am. J. Hum. Genet. 71, 1195-1199 (Pubitemid 35305238)
22. Kohlhase, J., Schuh, R., Dowe, G., Kuhnlein, R. P., Jackle, H., Schroeder, B., Schulz-Schaeffer, W., Kretzschmar, H. A., Kohler, A., Muller, U., Raab-Vetter, M., Burkhardt, E., Engel, W., and Stick, R. (1996) Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt. Genomics 38, 291-298 (Pubitemid 27030117)
23. Zhang, J., Tam, W. L., Tong, G. Q., Wu, Q., Chan, H. Y., Soh, B. S., Lou, Y., Yang, J., Ma, Y., Chai, L., Ng, H. H., Lufkin, T., Robson, P., and Lim, B. (2006) Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat. Cell Biol. 8, 1114-1123 (Pubitemid 44473607)
24. Yang, J., Chai, L., Liu, F., Fink, L. M., Lin, P., Silberstein, L. E., Amin, H. M., Ward, D. C., and Ma, Y. (2007) Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc. Natl. Acad. Sci. U. S. A. 104, 10494-10499 (Pubitemid 47185693)
25. Ma, Y., Cui, W., Yang, J., Qu, J., Di, C., Amin, H. M., Lai, R., Ritz, J., Krause, D. S., and Chai, L. (2006) SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 108, 2726-2735 (Pubitemid 44777010)
26. Bohm, J., Sustmann, C., Wilhelm, C., and Kohlhase, J. (2006) SALL4 is directly activated by TCF/LEF in the canonical Wnt signaling pathway. Biochem. Biophys. Res. Commun. 348, 898-907 (Pubitemid 44233503)
27. Burke, W. M., Jin, X., Lin, H. J., Huang, M., Liu, R., Reynolds, R. K., and Lin, J. (2001) Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 20, 7925-7934 (Pubitemid 34002969)
28. Dien, J., Amin, H. M., Chiu, N., Wong, W., Frantz, C., Chiu, B., Mackey, J. R., and Lai, R. (2006) Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer. Am. J. Pathol. 169, 633-642 (Pubitemid 44156319)
29. Amin, H. M., McDonnell, T. J., Medeiros, L. J., Rassidakis, G. Z., Leventaki, V., O'Connor, S. L., Keating, M. J., and Lai, R. (2003) Characterization of 4 mantle cell lymphoma cell lines. Arch. Pathol. Lab. Med. 127, 424-431
30. Cui, W., Kong, N. R., Ma, Y., Amin, H. M., Lai, R., and Chai, L. (2006) Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod. Pathol. 19, 1585-1592 (Pubitemid 44789927)
31. Qian, L., Chen, L., Shi, M., Yu, M., Jin, B., Hu, M., Xia, Q., Zhang, X., Shen, B., and Guo, N. (2006) A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells. Biochem. Biophys. Res. Commun. 345, 660-668 (Pubitemid 43776992)
32. Kunisada, K., Tone, E., Fujio, Y., Matsui, H., Yamauchi-Takihara, K., and Kishimoto, T. (1998) Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. Circulation 98, 346-352 (Pubitemid 28348057)
33. Yang, J., Chai, L., Gao, C., Fowles, T. C., Alipio, Z., Dang, H., Xu, D., Fink, L. M., Ward, D. C., and Ma, Y. (2008) SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood 112, 805-813
34. Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E., Jr., Stein, R. B., and Rosen, J. (1995) Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. U. S. A. 92, 3041-3045
35. Ehret, G. B., Reichenbach, P., Schindler, U., Horvath, C. M., Fritz, S., Nabholz, M., and Bucher, P. (2001) DNA binding specificity of different STAT proteins: comparison of in vitro specificity with natural target sites. J. Biol. Chem. 276, 6675-6688 (Pubitemid 37373532)
36. Amin, H. M. McDonnell, T. J., Ma, Y., Lin, Q., Fujio, Y., Kunisada, K., Leventaki, V., Das, P., Rassidakis, G. Z., Cutler, C., Medeiros, L. J., and Lai, R. (2004) Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene 23, 5426-5434 (Pubitemid 39044053)
37. Zhang, F. L. C., Halfter, H., and Liu, J. (2003) Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 22, 894-905 (Pubitemid 36255825)
38. Elling, U., Klasen, C., Eisenberger, T., Anlag, K., and Treier, M. (2006) Murine inner cell mass-derived lineages depend on Sall4 function. Proc. Natl. Acad. Sci. U. S. A. 103, 16319-16324 (Pubitemid 44715194)
39. Monk, M., and Holding, C. (2001) Human embryonic genes re-expressed in cancer cells. Oncogene 20, 8085-8091 (Pubitemid 34028332)
40. Ezeh, U. I., Turek, P. J., Reijo, R. A., and Clark, A. T. (2005) Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 104, 2255-2265
41. Ben-Porath, I., Thomson, M. W., Carey, V. J., Ge, R., Bell, G. W., Regev, A., and Weinberg, R. A. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40, 499-507 (Pubitemid 351601215)
42. Chambers, I. (2004) The molecular basis of pluripotency in mouse embryonic stem cells. Cloning Stem Cells 6, 386-391 (Pubitemid 40023493)
43. Gibbs, C. P., Kukekov, V. G., Reith, J. D., Tchigrinova, O., Suslov, O. N., Scott, E. W., Ghivizzani, S. C., Ignatova, T. N., and Steindler, D. A. (2005) Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia 7, 967-976
44. Guo, Y., Mantel, C., Hromas, R. A., and Broxmeyer, H. E. (2008) Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin. Stem Cells 26, 30-34