TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain

Journal of Immunology

Volumn 183, Issue 6, 2009, Pages 3989-3995

  Carpenter, Susan ^a,b   Carlson, Thaddeus ^c   Dellacasagrande, Jerome ^b   Garcia, Amaya ^b,d   Gibbons, Sharon ^b   Hertzog, Paul ^e   Lyons, Anthony ^a   Lin, Lih Ling ^c   Lynch, Marina ^a   Monie, Tom ^f   Murphy, Caroline ^a,b   Seidl, Katherine J ^c   Wells, Christine ^g   Dunne, Aisling ^a   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ST JAMES S HOSPITAL   (Ireland)

^c PFIZER INC   (United States)

^d DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^e HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; LEUCINE RICH REPEAT KINASE 2; LIGAND; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; CARRIER PROTEIN; CYTOKINE; MEMBRANE PROTEIN; TLR4 PROTEIN, MOUSE; TRIL PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; BRAIN; CELL LINE; CYTOKINE PRODUCTION; GLIA CELL; HUMAN; KIDNEY PARENCHYMA; LUNG PARENCHYMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPINAL CORD; ANIMAL; BIOSYNTHESIS; BRAIN LEVEL; CELL CULTURE; CYTOLOGY; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PROTEIN BINDING; TUMOR CELL LINE;

ANIMALS; ASTROCYTOMA; BRAIN CHEMISTRY; CARRIER PROTEINS; CELL LINE, TUMOR; CELLS, CULTURED; CYTOKINES; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; TOLL-LIKE RECEPTOR 4;

EID: 70349336164     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901518     Document Type: Article

References (30)

1. Janeway, C. A., Jr. 1992. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13: 11-16.
2. Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397. (Pubitemid 27334820)
3. Nagai, Y., S. Akashi, M. Nagafuku, M. Ogata, Y. Iwakura, S. Akira, T. Kitamura, A. Kosugi, M. Kimoto, and K. Miyake. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3: 667-672. (Pubitemid 34752476)
4. Kim, H. M., B. S. Park, J. I. Kim, S. E. Kim, J. Lee, S. C. Oh, P. Enkhbayar, N. Matsushima, H. Lee, O. J. Yoo, and J. O. Lee. 2007. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130: 906-917.
5. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433.
6. Latz, E., A. Visintin, E. Lien, K. A. Fitzgerald, B. G. Monks, E. A. Kurt-Jones, D. T. Golenbock, and T. Espevik. 2002. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J. Biol. Chem. 277: 47834-47843. (Pubitemid 36159310)
7. Wakabayashi, Y., M. Kobayashi, S. Akashi-Takamura, N. Tanimura, K. Konno, K. Takahashi, T. Ishii, T. Mizutani, H. Iba, T. Kouro, et al. 2006. A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4. J. Immunol. 177: 1772-1779. (Pubitemid 44092514)
8. Takahashi, K., T. Shibata, S. Akashi-Takamura, T. Kiyokawa, Y. Wakabayashi, N. Tanimura, T. Kobayashi, F. Matsumoto, R. Fukui, T. Kouro, et al. 2007. A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. J. Exp. Med. 204: 2963-2976.
9. Yang, Y., B. Liu, J. Dai, P. K. Srivastava, D. J. Zammit, L. Lefrancois, and Z. Li. 2007. Heat shock protein gp96 is a master chaperone for Toll-like receptors and is important in the innate function of macrophages. Immunity 26: 215-226.
10. Harding, C. V. 2007. gp96 leads the way for toll-like receptors. Immunity 26: 141-143.
11. Divanovic, S., A. Trompette, S. F. Atabani, R. Madan, D. T. Golenbock, A. Visintin, R. W. Finberg, A. Tarakhovsky, S. N. Vogel, Y. Belkaid, et al. 2005. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat. Immunol. 6: 571-578.
12. Sali, A., and T. L. Blundell. 1993. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234: 779-815. (Pubitemid 24007801)
13. Wang, W., Y. Yang, L. Li, and Y. Shi. 2003. Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses. Biochem. Biophys. Res. Commun. 305: 981-988. (Pubitemid 36597860)
14. Landgren, C., D. R. Beier, R. Fassler, D. Heinegard, and Y. Sommarin. 1998. The mouse chondroadherin gene: characterization and chromosomal localization. Genomics 47: 84-91. (Pubitemid 28080084)
15. King, K. W., F. C. Sheppard, C. Westwater, P. L. Stern, and K. A. Myers. 1999. Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. Biochim. Biophys. Acta 1445: 257-270.
16. Bendtsen, J. D., H. Nielsen, G. von Heijne, and S. Brunak. 2004. Improved prediction of signal peptides: SignalP 3.0. J. Mol. Biol. 340: 783-795.
17. Dolan, J., K. Walshe, S. Alsbury, K. Hokamp, S. O'Keeffe, T. Okafuji, S. F. Miller, G. Tear, and K. J. Mitchell. 2007. The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics 8: 320.
18. Matsushima, N., T. Tanaka, P. Enkhbayar, T. Mikami, M. Taga, K. Yamada, and Y. Kuroki. 2007. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics 8: 124.
19. Nakata, T., M. Yasuda, M. Fujita, H. Kataoka, K. Kiura, H. Sano, and K. Shibata. 2006. CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex. Cell Microbiol. 8: 1899-1909. (Pubitemid 44680872)
20. 3 complex senses bacterial lipopeptides via vitronectin. Nat. Immunol. 9: 761-768.
21. Bruce, A. J., W. Boling, M. S. Kindy, J. Peschon, P. J. Kraemer, M. K. Carpenter, F. W. Holtsberg, and M. P. Mattson. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat. Med. 2: 788-794.
22. Clark, W. M., L. G. Rinker, N. S. Lessov, K. Hazel, J. K. Hill, M. Stenzel-Poore, and F. Eckenstein. 2000. Lack of interleukin-6 expression is not protective against focal central nervous system ischemia. Stroke 31: 1715-1720.
23. Caso, J. R., J. M. Pradillo, O. Hurtado, P. Lorenzo, M. A. Moro, and I. Lizasoain. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115: 1599-1608. (Pubitemid 46648645)
24. Caso, J. R., J. M. Pradillo, O. Hurtado, J. C. Leza, M. A. Moro, and I. Lizasoain. 2008. Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. Stroke 39: 1314-1320.
25. Klein, M., B. Obermaier, B. Angele, H. W. Pfister, H. Wagner, U. Koedel, and C. J. Kirschning. 2008. Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. J. Infect. Dis. 198: 1028-1036.
26. Rolls, A., R. Shechter, A. London, Y. Ziv, A. Ronen, R. Levy, and M. Schwartz. 2007. Toll-like receptors modulate adult hippocampal neurogenesis. Nat. Cell Biol. 9: 1081-1088. (Pubitemid 47338146)
27. Chen, Y., S. Aulia, L. Li, and B. L. Tang. 2006. AMIGO and friends: an emerging family of brain-enriched, neuronal growth modulating, type I transmembrane proteins with leucine-rich repeats (LRR) and cell adhesion molecule motifs. Brain. Res. Rev. 51: 265-274. (Pubitemid 44183828)
28. Ma, Y., J. Li, I. Chiu, Y. Wang, J. A. Sloane, J. Lu, B. Kosaras, R. L. Sidman, J. J. Volpe, and T. Vartanian. 2006. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J. Cell Biol. 175: 209-215. (Pubitemid 44631415)
29. Akiyama, H., S. Barger, S. Barnum, B. Bradt, J. Bauer, G. M. Cole, N. R. Cooper, P. Eikelenboom, M. Emmerling, B. L. Fiebich, et al. 2000. Inflammation and Alzheimer's disease. Neurobiol. Aging 21: 383-421.
30. Rojo, L. E., J. A. Fernandez, A. A. Maccioni, J. M. Jimenez, and R. B. Maccioni. 2008. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch. Med. Res. 39: 1-16.