Respiratory syncytial virus bronchiolitis and asthma - Insights from recent studies and implications for therapy

Inflammation and Allergy - Drug Targets

Volumn 8, Issue 3, 2009, Pages 202-207

  Mailaparambil, Beena ^a   Grychtol, Ruth ^a   Heinzmann, Andrea ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Association; Asthma; Bronchiolitis; Genetics; Polymorphism; RSV; Wheezing

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; DESLORATADINE; FORMOTEROL; HELPER FACTOR; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 8; MONTELUKAST; MOTAVIZUMAB; PALIVIZUMAB; RESPIRATORY SYNCYTIAL VIRUS ANTIBODY; RIBAVIRIN; SALBUTAMOL; SURFACTANT PROTEIN C; TUMOR NECROSIS FACTOR ALPHA; ALLERGEN; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT;

ASTHMA; CHRONIC LUNG DISEASE; COST EFFECTIVENESS ANALYSIS; DRUG COST; DRUG EFFICACY; DRUG SAFETY; EPIDEMIOLOGICAL DATA; GENE ACTIVITY; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; ONSET AGE; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; UNSPECIFIED SIDE EFFECT; VIRAL BRONCHIOLITIS; VIRUS INFECTION; WHEEZING; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; LUNG; PATHOLOGY; VIROLOGY;

ALLERGENS; ANTI-INFLAMMATORY AGENTS; ANTIVIRAL AGENTS; ASTHMA; BRONCHIOLITIS, VIRAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUNG; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN;

EID: 70349332589     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152809788681056     Document Type: Review

References (59)

1. Hall, C.B.; Weinberg, G.A.; Iwane, M.K.; Blumkin, A.K.;, Edwards, K.M.; Staat, M.A.; Auinger, P.; Griffin, M.R.; Poehling, K.A.; Erdman, D.; Grijalva, C.G.; Zhu, Y.; Szilagyi, P. The burden of respiratory syncytial virus infection in young children. N. Eng. L. Med., 2009, 360, 588-598.
2. Stein, R.T.; Sherrill, D.; Morgan, W.J.; Holberg, C.J.; Halonen, M.; Taussig, L.M.; Wright, A.L.; Martinez, F.D. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet, 1999, 354, 541-545.
3. Sigurs, N.; Gustafsson, P.M.; Bjarnason, R.; Lundberg, F.; Schmidt, S.; Sigurbergsson, F.; Kjellman, B. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am. J. Respir. Crit. Care Med., 2005, 17, 137-141.
4. Stensballe, L.G.; Simonsen, J.B.; Thomsen, S.F.; Larsen, A.M.; Lysdal, S.H.; Aaby, P.; Kyvik, K.O.; Skytthe, A.; Backer, V., Bisgaard, H. The causal direction in the association between respiratory syncytial virus hospitalization and asthma J. Allergy Clin. Immunol., 2009, 123, 131-137.
5. Mohapatra, S.S.; Boyapalle, S. Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma. Clin. Microbiol. Rev., 2008, 21, 495-504.
6. Thomsen, S.F.; Sluis, S.V.; Stensballe, L.G.; Posthuma, D.; Skytthe, A.; Kyvik, K.O.; Duffy, D.L.; Backer, V.; Bisgaard, H. Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study. Am. J. Respir. Crit. Care Med., 2009 Mar 12.
7. Openshaw, P.J.; Dean, G.S.; Culley, F.J. Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches. Pediatr. Infect. Dis. J. 2003, 22, 58-64.
8. Henderson, J.; Hilliard, T.N.; Sherriff, A.; Stalker, D; Al Shammari, N.; Thomas, H.M. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr. Allergy Immunol., 2005, 16, 386-392.
9. Pérez-Yarza, E.G.; Moreno, A.; Lázaro, P; Mejías, A.; Ramilo, O. The association between respiratory syncytial virus infection and the development of childhood asthma: a systematic review of the literature. Pediatr. Infect. Dis. J., 2007, 26, 733-739.
10. Cassimos, D.C.; Tsalkidis, A.; Tripsianis, G.A.; Stogiannidou, A.; Anthracopoulos, M.; Ktenidou-Kartali, S.; Aivazis, V.; Gardikis, S.; Chatzimichael, A.. Asthma, lung function and sensitization in school children with a history of bronchiolitis. Pediatr. Int., 2008, 50, 51-56.
11. Sigurs, N.; Bjarnason, R.; Sigurbergsson, F.; Kjellman, B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am. J. Respir. Crit. Care Med., 2000, 161, 1501-1507.
12. Kusel, M.M.; de Klerk, N.H.; Kebadze, T.; Vohma, V.; Holt, P.G.; Johnston, S.L.; Sly, P.D. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J. Allergy Clin. Immunol., 2007, 119, 1105-1110.
13. Piippo-Savolainen, E.; Remes, S.; Kannisto, S.; Korhonen, K.; Korppi, M. Asthma and lung function 20 years after wheezing in infancy: results from a prospective follow-up study. Arch Pediatr. Adolesc. Med., 2004, 158, 1070-1076.
14. Korppi, M.; Piippo-Savolainen, E.; Korhonen, K.; Remes, S. Respiratory morbidity 20 years after RSV infection in infancy. Pediatr. Pulmonol., 2004, 38, 155-160.
15. Martinez, F.D. Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma. Pediatr. Infect. Dis. J., 2003, 22, 76-82.
16. Martinez, F.D.; Wright, A.L.; Taussig, L.M.; Holberg, C.J.; Halonen, M.; Morgan, W.J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N. Engl. J. Med., 1995, 332, 133-138.
17. Lemanske, R.F. Jr. The childhood origins of asthma (COAST) study. Pediatr. Allergy Immunol., 2002, 13, 38-43.
18. Jackson, D.J.; Gangnon, R.E.; Evans, M.D.; Roberg, K.A.; Anderson, E.L.; Pappas, T.E.; Printz, M.C.; Lee, W.M.; Shult, P.A.; Reisdorf, E.; Carlson-Dakes, K.T.; Salazar, L.P.; DaSilva, D.F.; Tisler, C.J.; Gern, J.E.; Lemanske, R.F. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am. J. Respir. Crit. Care Med., 2008, 178, 667-667.
19. Lemanske, R.F. Jr; Jackson, D.J.; Gangnon, R.E.; Evans, M.D.; Li, Z.; Shult, P.A.; Kirk, C.J.; Reisdorf, E.; Roberg, K.A.; Anderson, E.L.; Carlson-Dakes, K.T.; Adler, K.J.; Gilbertson-White, S.; Pappas, T.E.; Dasilva, D.F.; Tisler, C.J.; Gern, J.E. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J. Allergy Clin. Immunol., 2005, 116, 571-577.
20. Lander, E.S.; Schork, N.J. Genetic dissection of complex traits Science, 1994, 265, 2037-2048.
21. Thomsen, S.F.; Stensballe, L.G.; Skytthe, A.; Kyvik, K.O.; Backer, V.; Bisgaard, H. Increased concordance of severe respiratory syncytial virus infection in identical twins. Pediatrics, 2008, 121, 493-496.
22. Vercelli, D. Discovering susceptibility genes for asthma and allergy. Nat. Rev. Immunol., 2008, 8, 169-182.
23. Ober, C.; Hoffjan, S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun., 2006, 7, 95-100.
24. Puthothu, B.; Bierbaum, S.; Kopp, M.V.; Forster, J.; Heinze, J.; Weckmann, M.; Krueger, M.; Heinzmann, A. Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma. Pediatr. Allergy Immunol., 2008, 20, 157-63.
25. Randolph, A.G.; Lange, C.; Silverman, E.K.; Lazarus, R.; Weiss, S.T. Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am. J. Respir. Crit. Care Med., 2005, 172, 687-692.
26. Puthothu, B.; Krueger, M.; Bernhardt, M.; Heinzmann, A. ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels. Genes Immun., 2006, 7, 322-326.
27. Li, Y.F.; Tsao, Y.H.; Gauderman, W.J.; Conti, D.V.; Avol, E.; Dubeau, L.; Gilliland, F.D. Intercellular adhesion molecule-1 and childhood asthma. Hum. Genet., 2005, 117, 476-484.
28. Puthothu, B.; Krueger, M.; Forster, J.; Heinze, J.; Weckmann, M.; Heinzmann, A. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Pediatr. Infect. Dis. J., 2007, 26, 1094-1098.
29. Basehore, M.J.; Howard, T.D.; Lange, L.A.; Moore, W.C.; Hawkins, G.A.; Marshik, P.L.; Harkins, M.S.; Meyers, D.A.; Bleecker, E.R. A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects. J. Allergy Clin. Immunol., 2004, 114, 80-87.
30. Forton, J.T.; Rowlands, K.; Hanchard, N.; Herbert, M.; Kwiatkowski, D.P.; Hull, Genetic association study for RSV Bronchiolitis in infancy at the 5q31 cytokine cluster. J. Thorax, 2009, Jan 8.
31. Janssen, R.; Bont, L.; Siezen, C.L.; Hodemaekers, H.M.; Ermers, M.J.; Doornbos, G.; van 't Slot, R.; Wijmenga, C.; Goeman, J.J.; Kimpen, J.L.; van Houwelingen, H.C.; Kimman, T.G.; Hoebee, B. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J. Infect. Dis., 2007, 196, 826-834.
32. Holla, L.I.; Jurajda, M.; Pohunek, P.; Znojil, V. Haplotype analysis of the endothelial nitric oxide synthase gene in asthma. Hum. Immunol., 2008, 69, 306-311.
33. Weidinger, S.; Gieger, C.; Rodriguez, E.; Baurecht, H.; Mempel, M.; Klopp, N.; Gohlke, H.; Wagenpfeil, S.; Ollert, M.; Ring, J.; Behrendt, H.; Heinrich, J.; Novak, N.; Bieber, T.; Krämer, U.; Berdel, D.; von Berg, A.; Bauer, C.P.; Herbarth, O.; Koletzko, S.; Prokisch, H.; Mehta, D.; Meitinger, T.; Depner, M.; von Mutius, E.; Liang, L.; Moffatt, M.; Cookson, W.; Kabesch, M.; Wichmann, H.E.; Illig, T. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet., 2008, 4, e1000166.
34. Zhang, H.; Zhang, Q.; Wang, L.; Chen, H.; Li, Y.; Cui, T.; Huang, W.; Zhang, L.; Yan, F.; Wang, L.; Xu, Y.; Hu, L.; Kong, X. Association of IL4R gene polymorphisms with asthma in Chinese populations. Hum. Mutat., 2007, 28, 1046-1050.
35. Weidinger, S.; Klopp, N.; Wagenpfeil, S.; Rümmler, L.; Schedel, M.; Kabesch, M.; Schäfer, T.; Darsow, U.; Jakob, T.; Behrendt, H.; Wichmann, H.E.; Ring, J.; Illig, T. Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J. Med. Genet., 2004, 41, 658-563.
36. Lyon, H.; Lange, C.; Lake, S.; Silverman, E.K.; Randolph, A.G.; Kwiatkowski, D.; Raby, B.A.; Lazarus, R.; Weiland, K.M.; Laird, N.; Weiss, S.T. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet. Epidemiol., 2004, 26, 155-165.
37. Zhang, J.; Paré, P.D.; Sandford, A.J. Recent advances in asthma genetics. Respir. Res., 2008, 9, 4.
38. Puthothu, B.; Forster, J.; Heinze, J.; Heinzmann, A.; Krueger, M. Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma. BMC Pulm. Med., 2007, 7, 6.
39. Puthothu, B.; Forster, J.; Heinzmann, A.; Krueger, M. TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease. Dis. Markers, 2006, 22, 303-308.
40. Tal, G.; Mandelberg, A.; Dalal, I.; Cesar, K.; Somekh, E.; Tal, A.; Oron, A.; Itskovich, S.; Ballin, A.; Houri, S.; Beigelman, A.; Lider, O.; Rechavi, G.; Amariglio, N. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J. Infect. Dis., 2004, 189, 2057-2063.
41. Roth, D.E.; Jones, A.B.; Prosser, C.; Robinson, J.L.; Vohra, S. Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. J. Infect. Dis., 2008, 197, 676-680.
42. Heinzmann, A.; Ahlert, I.; Kurz, T.; Berner, R.; Deichmann, K.A. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J. Allergy Clin. Immunol., 2004, 114, 671-676.
43. Puthothu, B.; Krueger, M.; Heinze, J.; Forster, J.; Heinzmann, A. Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. Clin. Mol. Allergy, 2006, 4, 2.
44. Puthothu, B.; Krueger, M.; Heinze, J.; Forster, J.; Heinzmann, A. Haplotypes of surfactant protein C are associated with common paediatric lung diseases. Pediatr. Allergy Immunol., 2006, 17, 572-577.
45. Hall, C.B. Respiratory syncytial virus and parainfluenza virus. N. Engl. J. Med., 2001, 344, 1917-928.
46. Lemanske, R.F. Viral infections and asthma inception. J. Allergy Clin. Immunol., 2004, 114, 1023-1026.
47. Cornell, A.; Shaker, M.; Woodmansee, D.P. Update on the pathogenesis and management of childhood asthma. Curr. Opin. Pediatr., 2008, 20, 597-604.
48. Davison, C.; Ventre, K.M.; Luchetti, M.; Randolph, A.G. Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis. Pediatr. Crit. Care Med., 2004, 5, 482-489.
49. Patel, H.; Platt, R.; Lozano, J.M.; Wang, E.E. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst. Rev., 2004, 3, CD004878.
50. Ventre, K.; Randolph, A.G. Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst. Rev., 2007, 1, CD000181.
51. Fuller, H.; Del Mar, C. Immunoglobulin treatment for respiratory syncytial virus infection Cochrane Database Syst. Rev., 2006, 4, CD004883.
52. Blümchen, K.; Gerhold, K.; Thorade, I.; Seib, C.; Wahn, U.; Hamelmann, E. Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyperreactivity in mice. Clin. Exp. Allergy, 2004, 34, 1124-1130.
53. Bryce, P.J.; Geha, R.; Oettgen, H.C. Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. J. Allergy Clin. Immunol., 2003, 112, 149-158.
54. Wang, D.; Cummins, C.; Bayliss, S.; Sandercock, J.; Burls, A. Immunoprophylaxis against respiratory syncytial virus (RSV) with palivizumab in children: a systematic review and economic evaluation. Health Technol. Assess., 2008, 12, 1-86.
55. Abarca, K.; Jung, E.; Fernández, P.; Zhao, L.; Harris, B.; Connor, E.M.; Losonsky, G.A. for the Motavizumab Study Group. Safety, tolerability, pharmacokinetics, and immunogenicity of motavizumab, a humanized, enhanced-potency monoclonal antibody for the prevention of respiratory syncytial virus infection in At-risk children. Pediatr. Infect. Dis. J., 2009, 28, 267-272.
56. Moffatt, M.F.; Kabesch, M.; Liang, L.; Dixon, A.L.; Strachan, D.; Heath, S.; Depner, M.; von Berg, A.; Bufe, A.; Rietschel, E.; Heinzmann, A.; Simma, B.; Frischer, T.; Willis-Owen, S.A.; Wong, K.C.; Illig, T.; Vogelberg, C.; Weiland, S.K.; von Mutius, E.; Abecasis, G.R.; Farrall, M.; Gut, I.G.; Lathrop, G.M.; Cookson, W.O. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 2007, 448, 470-3
57. Drazen, J.M.; Yandava, C.N.; Dubé, L.; Szczerback, N.; Hippensteel, R.; Pillari, A.; Israel, E.; Schork, N.; Silverman, E.S.; Katz, D.A.; Drajesk, J. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat. Genet., 1999, 22, 168-70.
58. Mougey, E.B.; Feng, H.; Castro, M.; Irvin, C.G.; Lima, J.J. Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. Pharmacogenet. Genom., 2009, 19, 129-138.
59. Telleria, J.J.; Blanco-Quiros, A.; Varillas; D.; Armentia; A.; Fernandez-Carvajal, I.; Jesus Alonso, M.; Diez, I. ALOX5 promoter genotype and response to montelukast in moderate persistent asthma. Respir. Med., 2008, 102, 857-61.