Ears "made of stone" - Secondary phenomenon of undersubstituted adrenal insufficiency;Ohren "aus stein" - ungewöhnlicher begleitbefund aufgrund einer untersubstituierten nebenniereninsuffizienz

Deutsche Medizinische Wochenschrift

Volumn 134, Issue 38, 2009, Pages 1869-1871

  Richter, J C ^a,b   Chappuis, B ^a  

^a Medizinische Klinik   (Switzerland)

^b SOUTHLAND HOSPITAL   (New Zealand)

Author keywords

Adrenal insufficiency; Auricular ossification; Elastic cartilage; Glucocorticoids

Indexed keywords

HYDROCORTISONE; ANTIINFLAMMATORY AGENT;

ADRENAL CORTEX INSUFFICIENCY; ADRENAL INSUFFICIENCY; AGED; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; HUMAN; LUNG INFECTION; MALE; ADDISON DISEASE; CALCINOSIS; CARTILAGE; EAR DISEASE; HETEROTOPIC OSSIFICATION; LEGIONNAIRE DISEASE; PATHOLOGY; RADIOGRAPHY;

ADDISON DISEASE; AGED; ANTI-INFLAMMATORY AGENTS; CALCINOSIS; CARTILAGE; EAR DISEASES; HUMANS; HYDROCORTISONE; LEGIONNAIRES' DISEASE; MALE; OSSIFICATION, HETEROTOPIC;

EID: 70349330666     PISSN: 00120472     EISSN: 14394413     Source Type: Journal    
DOI: 10.1055/s-0029-1237526     Document Type: Article

References (15)

1. Agut Fuster MÀ et al. Calcification of auricular cartilages in adrenal insufficiency.Acta Otorrinolaringol Esp 2007; 58: 167-168
2. Barkan A, Glantz I. Calcification of auricular cartilages in patients with hypopituitarism. J Clin Endocrinol Metab 1982; 55: 354
3. Clarke J T., Clarke L E., Miller J J. Petrified ears: calcification of the auricular cartilage. J Am Acad Dermatol 2004 51 799-800
4. Derfoul A et al. Glucocorticoids promote chondrogenic differentiation of adult human mesenchymal stem cells by enhancing expression of cartilage extracellular matrix genes. Stem Cells 2006; 24: 1487-1495
5. Fukushima K, et al. Shock and stony hard ears. Lancet 2007 369 856
6. High WA et al. Idiopathic bilateral auricular ossificans: a case report and review of the literature. Arch Pathol Lab Med 2004; 128: 1432-1434
7. James CG, Ulici V, Tuckermann J et al. Expression profiling of dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in enchondral bone development. BMC Genomics 2007; 8: 205
8. Manni JJ, Berénos-Riley LCM. Ossification of the external ear: a case report and review of the literature. Eur Arch Otorhinolaryngol 2005; 262: 961-964
9. Nilsson O, Marino R, De Luca F, Phillip M, Baron J. Endocrine regulation of the growth plate. Horm Res 2005 64 157-165
10. Randall RE, Spong FW. Calcification of the auricular cartilage in a patient with hypopituitarism. N Engl J Med 1963; 269: 1135-1137
11. Schäfer C, Heiss A, Schwarz A et al. The serum protein α2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 2003; 112: 357-366
12. Siebenmann R E. Die Ohrknorpelverknöcherung beim Morbus Addison. Schweiz Med Wochenschr 1977 107 468-474
13. Van der Eerden BCJ, Karperien M, Wit JM. Systemic and local regulation of the growth plate. Endocr Rev 2003; 24: 782-801
14. Wöltje M, Tschöke B, von Blow V et al. CCAAT enhancer binding protein β and hepatocyte nuclear factor 3β are necessary and sufficient to mediate dexamethasone-induced up-regulation of alpha2-HS glycoprotein/fetuin - A gene expression. J Mol Endocrinol 2006; 36: 261-277
15. Zillessen E, Gless KH, Baldauf G. Verknöcherung der Ohrmuschel bei partieller Hypophyseninsuffizienz mit selektivem ACTH- und STH-Mangel. Dtsch Med Wochenschr 1978; 103: 698-701