Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy

Epilepsy and Behavior

Volumn 10, Issue 1, 2007, Pages 105-110

  Weintraub, D ^a   Buchsbaum, R ^b   Resor Jr , S R ^a   Hirsch, L J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Columbia University ^*  (United States)

Author keywords

Antiepileptic drugs; Behavioral; Epilepsy; Felbamate; Gabapentin; Lamotrigine; Levetiracetam; Oxcarbazepine; Psychiatric; Side effects; Topiramate; Vigabatrin; Zonisamide

Indexed keywords

ANTICONVULSIVE AGENT; ETIRACETAM; FELBAMATE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; TIAGABINE; TOPIRAMATE; VIGABATRIN; ZONISAMIDE;

ADULT; ANXIETY; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DEPRESSION; DRUG DOSE REGIMEN; DRUG WITHDRAWAL; EPILEPSY; FEMALE; HUMAN; INCIDENCE; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MONOTHERAPY; OUTPATIENT; PREDICTION; PSYCHOSIS; SIDE EFFECT;

ADULT; ANTIEMETICS; BEHAVIORAL SYMPTOMS; EPILEPSY; FEMALE; HUMANS; MALE; MENTAL DISORDERS; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 33846357448     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2006.08.008     Document Type: Article

References (18)

1. Besag F.M. Behavioural effects of the newer antiepileptic drugs: an update. Expert Opin Drug Saf 3 (2004) 1-8
2. Ketter T.A., Post R.M., and Theodore W.H. Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology 53 5Suppl. 2 (1999) S53-S67
3. Schmitz B. Psychiatric syndromes related to antiepileptic drugs. Epilepsia 40 Suppl.10 (1999) S65-S70
4. Glauser T.A. Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy. Epilepsy Behav 5 Suppl.3 (2004) S25-S32
5. Baker G.A., and Marson A.G. Cognitive and behavioural assessments in clinical trials: what type of measure?. Epilepsy Res 45 (2001) 163-167 discussion 169-70
6. Cramer J.A., Fisher R., Ben-Menachem E., French J., and Mattson R.H. New antiepileptic drugs: comparison of key clinical trials. Epilepsia 40 (1999) 590-600
7. Wong I.C., and Lhatoo S.D. Adverse reactions to new anticonvulsant drugs. Drug Saf 23 (2000) 35-56
8. Cramer J.A., De Rue K., Devinsky O., Edrich P., and Trimble M.R. A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials. Epilepsy Behav 4 (2003) 124-132
9. Dinkelacker V., Dietl T., Widman G., Lengler U., and Elger C.E. Aggressive behavior of epilepsy patients in the course of levetiracetam add-on therapy: report of 33 mild to severe cases. Epilepsy Behav 4 (2003) 537-547
10. Mula M., Trimble M.R., Yuen A., Liu R.S., and Sander J.W. Psychiatric adverse events during levetiracetam therapy. Neurology 61 (2003) 704-706
11. Weintraub D., Resor S., Bazil C., and Hirsch L.J. Head to head comparison of antiepileptic drug effectiveness in adults with epilepsy. Neurology 64 6Suppl.1 (2005) A188
12. Barbosa L., Berk M., and Vorster M. A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry 64 (2003) 403-407
13. GlaxoSmithKline. Lamotrigine Package Insert. 2005.
14. Meador K.J., Loring D.W., and Vahle V.J. Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers. Neurology 64 (2005) 2108-2114
15. Mula M., Trimble M.R., and Sander J.W. Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam. Seizure 13 (2004) 55-57
16. Mula M., Trimble M.R., Lhatoo S.D., and Sander J.W. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia 44 (2003) 659-663
17. Trimble M.R., Rusch N., Betts T., and Crawford P.M. Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables. Seizure 9 (2000) 249-254
18. Krishnamoorthy E.S. Psychiatric issues in epilepsy. Curr Opin Neurol 14 (2001) 217-224