Perivascular gene transfer of dominant-negative N19RhoA attenuates neointimal formation via inhibition of TGF-β1-Smad2 signaling in rats after carotid artery balloon injury

Biochemical and Biophysical Research Communications

Volumn 389, Issue 2, 2009, Pages 217-223

  Chen, WenDong ^a,b,c   Chu, YuFeng ^d   Zhu, DingLiang ^a,b,c   Yan, Chen ^e   Liu, JianJun ^a   Ji, KaiDa ^a   Gao, PingJin ^a,b,c  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c State Key Laboratory of Medical Genomics   (China)

^d SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Adventitial fibroblast; Myofibroblast; Restenosis; RhoA; Smad2; TGF 1

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SMOOTH MUSCLE ACTIN; CALPONIN; COLLAGEN; GREEN FLUORESCENT PROTEIN; PROTEIN N19RHOA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY INJURY; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; FIBROBLAST; GENE TRANSFER; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

ACTINS; ADENOVIRIDAE; ANGIOPLASTY, BALLOON; ANIMALS; CALCIUM-BINDING PROTEINS; CAROTID ARTERIES; CAROTID ARTERY INJURIES; CELL DIFFERENTIATION; FIBROBLASTS; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HYPERPLASIA; MALE; MICROFILAMENT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ADENOVIRIDAE; RATTUS; RENILLA;

EID: 70349329229     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.104     Document Type: Article

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