RapidTEG Observation Suggests Activation of Factor VII May Overcome Argatroban-Induced Coagulopathy

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 23, Issue 5, 2009, Pages 752-753

  Schmitz, Michael L ^a   St Amour, Edgar D ^a   Harness, H Lynn ^a   McKamie, Wesley A ^a   Johnson, Charles E ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGATROBAN; BLOOD CLOTTING FACTOR 7A; HEPARIN; KAOLIN; THROMBOPLASTIN;

ANTICOAGULATION; ARTERY RUPTURE; BLEEDING; BLOOD CLOTTING DISORDER; CASE REPORT; CHILD; FEMALE; HEMOSTASIS; HUMAN; LETTER; PRESCHOOL CHILD; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA; THROMBOELASTOGRAPHY; THROMBOGENESIS;

BLOOD COAGULATION DISORDERS; CHILD; FACTOR VII; FEMALE; HUMANS; PIPECOLIC ACIDS; THROMBELASTOGRAPHY; TIME FACTORS;

EID: 70349326729     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2008.08.009     Document Type: Letter

References (4)

1. Young G., Yonekawa K.E., Nakagawa P.A., et al. Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography. Blood Coagul Fibrinolysis 18 (2007) 547-553
2. Malherbe S., Tsui B.C., Stobart K., et al. Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII. Anesthesiology 100 (2004) 443-447
3. Chi L., Gibson G., Peng Y.-W., et al. Characterization of a tissue factor/factor VIIa-dependent model of thrombosis in hypercholestrolemic rabbits. J Thromb Haemost 2 (2004) 85-92
4. Sørensen B., and Ingerslev J. A direct thrombin inhibitor studied by dynamic whole blood clot formation: Haemostatic response to ex-vivo addition of recombinant factor VIIa or activated prothrombin complex concentrate. Thromb Haemost 96 (2006) 446-453