Interaction between superantigen and T-cell receptor Vβ element determines levels of superantigen-dependent cell-mediated cytotoxicity of CD8+ T cells in induction and effector phases

Microbiology and Immunology

Volumn 53, Issue 8, 2009, Pages 451-459

  Li, Zhong Juan ^a   Omoe, Katsuhiko ^b   Shinagawa, Kunihiro ^b   Yagi, Junji ^a   Imanishi, Ken'Ichi ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b IWATE UNIVERSITY   (Japan)

Author keywords

Cd8+ T cell; SAG dependent cell mediated cytotoxicity; Superantigen

Indexed keywords

GRANZYME B; PERFORIN; STAPHYLOCOCCUS ENTEROTOXIN A; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN; ENTEROTOXIN; ENTEROTOXIN A, STAPHYLOCOCCAL; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLAST CELL; CD8+ T LYMPHOCYTE; CELL MEDIATED CYTOTOXICITY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNOSTIMULATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CYTOTOXICITY; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MICROBIOLOGY; STAPHYLOCOCCUS; STAPHYLOCOCCUS INFECTION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; ENTEROTOXINS; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; SUPERANTIGENS;

EID: 70349322738     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2009.00136.x     Document Type: Article

References (32)

1. Marrack P., Kappler J.W. (1989) The staphylococcal enterotoxins and their relatives. Science 248: 705-11.
2. Baker M.D., Acharya K.R. (2004) Superantigens: structure-function relationships. Int J Med Microbiol 293: 529-37.
3. Uchiyama T., Imanishi K., Miyoshi-Akiyama T., Kato H. (2006) Staphylococcal superantigens and the diseases they cause. In:Alouf J., Popoff M., eds. The Comprehensive Sourcebook of Bacterial Protein Toxins, 3rd edn. New York, USA: Elsevier Ltd, pp. 830-43.
4. Uchiyama T., Miyoshi-Akiyama T., Ueshiba H. (2007) Superantigens from gram-negative bacteria and the diseases that they cause. In:Kotb M., Fraser J., eds. Superantigens: Molecular Basis for their Role in Human Diseases.Washington, DC: ASM Press, pp. 77-89.
5. Takimoto H., Yoshikai Y., Kishihara K., Matsuzaki G., Kuga H., Otani T., Nomoto K. (1990) Stimulation of all T cells bearing V beta 1, V beta 3, V beta 11 and V beta 12 by staphylococcal enterotoxin A. Eur J Immunol 20: 617-21.
6. Callahan J.E., Herman A., Kappler J.W., Marrack P. (1990) Stimulation of B10.BR T cells with superantigenic staphylococcal toxins. J Immunol 144: 2473-9.
7. + T cells. J Immunol 168: 3817-24.
8. Dohlsten M., Lando P.A., Hedlund G. Trowsdale J., Kalland T. (1990) Targeting of human cytotoxic T lymphocytes to MHC class I1-expressing cells by staphylococcal enterotoxins. Immunology 71: 96-100.
9. + mononuclear leukocytes and freshly prepared leukemia cells. Cell Immunol 129: 426-34.
10. Hedlund G., Dohlsten M., Petersson C., Kalland T. (1993) Superantigen-based tumor therapy: in vivo activation of cytotoxic T cells. Cancer Immunol Immunother 36: 89-93.
11. Friedman M.E., Howard M.B. (1971) Induction of mutants of Staphylococcus aureus with increased ability to produce enterotoxin A. J Bacteriol 106: 289-91.
12. Hu D.L., Omoe K., Shimoda Y., Nakane A., Shinagawa K. (2003) Induction of emetic response to staphylococcal enterotoxins in the house musk shrew (Suncus murinus). Infect Immun 71: 567-70.
13. Omoe K., Ishikawa M., Shimoda Y., Hu D.L., Ueda S., Shinagawa K. (2002) Detection of seg, seh, and sei genes in Staphylococcus aureus isolates and determination of the enterotoxin productivities of S. aureus isolates harboring seg, seh, and sei genes. J Clin Microbiol 40: 857-62.
14. Omoe K., Imanishi K., Hu D.L., Kato H., Fugane Y., Abe Y., Hamaoka S.,Watanabe Y., Nakane A., Uchiyama T., Shinagawa K. (2005) Characterization of novel staphylococcal enterotoxin-like toxin type P. Infect Immun 73: 5540-6.
15. Yan X.J., Li X.Y., Imanishi K., Kumazawa Y., Uchiyama T. (1993) Study of activation of murine T cells with bacterial superantigens. J Immunol 150: 3873-81.
16. Lyons A. B., Parish C.R. (1994) Determination of lymphocyte division by flow cytometry. J Immunol Methods 171: 131-7.
17. Wells A.D., Gudmundsdottir H., Turka L.A. (1997) Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J Clin Invest 100: 3173-83.
18. Liu L., Chahroudi A., Silvestri G, Wernett M.E., Kaiser W.J., Safrit J.T., Komoriya A., Altman J.D., Packard B.Z., Feinberg M.B. (2002) Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates. Nat Med 8: 185-9.
19. Jerome K.R., Sloan D.D., Aubert M. (2003) Measuring T-cell-mediated cytotoxicity using antibody to activated caspase-3. Nat Med 9: 4-5.
20. Bueno C., Lemke C.D., Criado G., Baroja M.L., Ferguson S.S.G., Nur-Ur Rahman A.K.M., Tsoukas C.D., McCormick J.K., Madrenas J. (2006) Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Gα11-dependent, PLC-β-mediated pathway. Immunity 25: 67-78.
21. Shresta S., Pham C.T.N., Thomas D.A., Graubert T.A., Ley T.J. (1998) How do cytotoxic lymphocytes kill their targets. Curr Opin Immunol 10: 581-7.
22. Lieberman J. (2003) The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 3: 361-70.
23. Russell J.H., Ley T.J. (2002) Lymphocyte- mediated cytotoxicity. Annu Rev Immunol 20: 323-70.
24. Barry M., Bleackley R.C. (2002) Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol 2: 401-9.
25. Babichuk C.K., Duggan B.L., Bleackley R.C. (1996) In vivo regulation of murine granzyme B gene transcription in activated primary T cells. J Biol Chem 271: 16485-93.
26. Griffiths G.M. (1997) Protein sorting and secretion during CTL killing. Semin Immunol 9: 109-15.
27. Fehniger T.A., Cai S.F., Cao X., Bredemeyer A.J., Presti R.M., French A.R., Ley T.J. (2007) Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity 26: 798-811.
28. Hudson K.R., Robinson H., Fraser J.D. (1993) Two adjacent residue in staphylococcal enterotoxins A and E determine T cell receptor Vβ specificity. J Exp Med 177: 175-84.
29. Antonsson P., Wingren A.G., Hansson J., Kalland T., Varga M., Dohlsten M. (1997) Functional characterization of the interaction between the superantigen staphylococcal enterotoxin A and the TCR. J Immunol 158: 4245-51.
30. Miethke T., Wahl C., Heeg K., Echtenacher B., Krammer P.H., Wagner H. (1992) T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: Critical role of tumor necrosis factor. J Exp Med 175: 91-8.
31. Matsuda Y., Kato H., Yamada R., Okano H., Ohta H., Imanishi K., Kikuchi K., Totsuka K., Uchiyama T. (2003) Early and definitive diagnosis of toxic shock syndrome by detection of marked expansion of T-cell-receptor Vβ2-positive T cells. Emerg Infect Dis 9: 387-9.
32. Sundstedt A., Grundstrom S., Dohlsten M. (1998) T cell- and perforin-dependent depletion of B cells in vivo by staphylococcal enterotoxin A. Immunol 95: 6-82.