Functional Characterization of the Interaction between the Superantigen Staphylococcal Enterotoxin A and the TCR

Journal of Immunology

Volumn 158, Issue 9, 1997, Pages 4245-4251

  Antonsson, Per ^a,b   Wingren, Anette Gjörloff ^a   Hansson, Johan ^a   Kalland, Terje ^a   Varga, Mikael ^a   Dohlsten, Mikael ^a  

^a LUND UNIVERSITY   (Sweden)

^b Pharmacia & Upjohn AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ENTEROTOXIN; ENTEROTOXIN A, STAPHYLOCOCCAL; ENTEROTOXIN E, STAPHYLOCOCCAL; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; SUPERANTIGEN;

AMINO ACID SEQUENCE; ARTICLE; CELL CULTURE; CHEMISTRY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; ENTEROTOXINS; HUMANS; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPERANTIGENS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031136957     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.158.9.4245     Document Type: Article

References (33)

1. Schad, E. M., I. Zaitseva, V. N. Zaitsev, M. Dohlsten, T. Kalland, P. M. Schlievert, D. H. Ohlendorf, and L. A. Svensson. 1995. Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO J. 14:3292.
2. Ahrahmsén, L., M. Dohlsten, S. Segrén, P. Björk, E. Jonsson, and T. Kalland. 1995. Characterization of two distinct MHC Class II binding sites in the superantigen staphylococcal enterotoxin A. EMBO J. 14:2978.
3. Fraser, J. D., R. G. Urban, J. L. Strominger, and H. Robinson. 1992. Zinc regulates the function of two superantigens. Proc. Natl. Acad. Sci. USA 89:5507.
4. Fraser, J. D., S. Lowe, M. J. Irwin, N. R. J. Gascoigne, and K. R. Hudson. 1993. Structural model of staphylococcal enterotoxin A interactions with MHC class II antigens. In A Pathogen's View of the Immune System: Current Communications in Cell and Molecular Biology. B. T. Huber and E. Palmer, eds. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 7-29.
5. Hudson, K. R., R. E. Tiedmann, R. G. Urban, S. C. Lowe, J. L. Strominger, and J. D. Fraser. 1995. Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II. J. Exp. Med. 182:711.
6. Grossman, D., M. Van, J. A. Mollick, S. K. Highlander, and R. R. Rich. 1991. Mutation of the disulfide loop in staphylococcal enterotoxin A: consequences for T cell recognition. J. Immunol. 147:3274.
7. Kappler, J. W., A. Herman, J. Clements, and P. Marrack. 1992. Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J. Exp. Med. 175:387.
8. Hudson, K. R., H. Robinson, and J. D. Fraser. 1993. Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity. J. Exp. Med. 177:175.
9. Irwin, M. J., K. R. Hudson, J. D. Fraser, and N. R. Gascoigne. 1992. Enterotoxin residues determining T-cell receptor Vβ binding specificity. Nature 359:841.
10. Mollick, J. A., R. L. McMasters, D. Grossman, and R. R. Rich. 1993. Localization of a site on bacterial superantigens that determines T cell receptor beta chain specificity. J. Exp. Med. 177:283.
11. Mahana, W., R. al-Daccak, and C. Leveille. 1995. A natural mutation of the amino acid residue at position 60 destroys staphylococcal entertoxin A murine T-cell mitogenicity. Infect. Immun. 63:2826.
12. Lamphear, J. G., J. A. Mollick, K. B. Reda, and R. R. Rich. 1996. Residues near the amino and carboxyl termini of staphylococcal enterotoxin E independently mediate TCR Vβ-specific interactions. J. Immunol. 156:2178.
13. Fields, B. A., E. L. Malchiodi, H. M. Li, X. Ysern, C. V. Stauffacher, P. M. Schlievert, K. Karjalainen, and R. A. Mariuzza. 1996. Crystal structure of a T cell receptor beta chain complexed with a superantigen. Nature 384:188.
14. Pontzer, C. H., M. J. Irwin, N. R. J. Gascoigne, and H. M. Johnson. 1992. T-cell antigen receptor sites for the microbial superantigen staphylococcal entertoxin A. Proc. Natl. Acad. Sci. USA 89:7727.
15. Blackmann, M. A., H. P. Smith, R. Wen, A. M. Deckhut, and D. L. Woodland. T-cell recognition of superantigen: role of non-Vβ TCR elements and MHC class II molecules. In A Pathogen's View of the Immune System: Current Communications in Cell and Molecular Biology. B. T. Huber and E. Palmer, eds. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 75-92.
16. Lundin, K. E., J. E. Brinchmann, and T. Hansen. 1994. Interactions between staphylococcal superantigens and human T-cell clones are predominantly but not exclusively governed by their T-cell receptor Vβ usage. Scand. J. Immunol. 39: 387.
17. Deckhut, A. M., Y. Chien, M. A. Blackmann, and D. L. Woodland. 1994. Evidence for a functional interaction between the β chain of major histocompatibility complex class II and the T cell receptor a chain during recognition of a bacterial superantigen. J. Exp. Med. 180:1931.
18. Horton, R. M., Z. L. Cai, S. N. Ho, and L. R. Pease. 1990. Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques 8:528.
19. Larson, L. N., C. Johansson, L. Lindholm, and J. Holmgren. 1988. Mouse monoclonal antibodies for experimental immunotherapy promotes killing of tumor cells. Int. J. Cancer 42:877.
20. von Heijne, G. 1986. A new method for predicting signal sequence cleavage sites. Nucleic Acids Res. 14:1483.
21. Lando, P. A., M. Dohlsten, G. Hedlund, T. Brodin, D. Sansom, and T. Kalland. 1993. Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity. Immunology 80: 236.
22. Lando, P. A., C. Olsson, T. Kalland, D. Newton, M. Kotb, and M. Dohlsten. 1996. Regulation of superantigen-induced T cell activation in the absence and presence of MHC class II. J. Immunol. 157:2857.
23. Thibodeau, T., I. Cloutier, P. M. Lavoie, N. Labrecque, W. Mourad, T. Jardetzky, and R.-P. Sékaly. 1994. Subsets of HLA-DRI molecules defined by SEB and TSST-1 binding. Science 266:1874.
24. Hedrick, S. M., I. Engel, D. L. McElligott, P. J. Fink, M.-L. Hsu, D. Hansburg, and L. A. Matis. 1988. Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science 239:1541.
25. Fleury, S., D. Lamarre, S. Meloche, S. E. Ryu, C. Cantin, W. A. Hendrickson, and R. P. Sékaly. 1991. Mutational analysis of the interaction between CD4 and class II MHC: class II antigens. Cell 66:1037.
26. Dohlsten, M., L. Ahrahmsén, P. Björk, P. A. Lando, G. Hedlund, G. Forsberg, T. Brodin, N. R. J. Gascoigne, C. Förberg, P. Lind, and T. Kalland. 1994. Monoclonal antibody-superantigen fusion proteins: tumor specific agents for T cell based tumor therapy. Proc. Natl. Acad. Sci. USA 91:8945.
27. Dohlsten, M., G. Hedlund, E. Åkerblom, P. A. Lando, and T. Kalland. 1991. Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents. Proc. Natl. Acad. Sci. USA 88:9287.
28. Kraulis, P. J. 1991. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Cryst. 24:946.
29. Cullen, C. M., L. R. Blanco, P. F. Bonventre, and E. Choi. 1995. A toxic shock syndrome toxin I mutant that defines a functional site critical for T-cell activation. Infect. Immun. 63:2141.
30. Valitutti, S., S. Müller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
31. Yagi, J., M. Nakata, T. Uchiyama, M. Nishikawa, Y. Mizuushima, K. Nishioka, K. Ito, K. Okumura, C. A. Janeway, Jr., and K. Yamamoto. 1994. Superantigen-like properties of antibody bispecific for MHC class II molecules and the Vβ domain of the T cell antigen receptor. J. Immunol. 152:2833.
32. Malchiodi, E. L., E. Eisenstein, B. A. Fields, D. H. Ohlendorf, P. M. Schlievert, K. Karjalainen, and R. A. Mariuzza. 1995. Superantigen binding to a T cell receptor b chain of known three-dimensional structure. J. Exp. Med. 182:1833.
33. Avery, A. C., J. S. Markowitz, M. J. Grusby, L. H. Glimcherand, and H. Cantor. 1994. Activation of T cells by superantigen in class II-negative mice. J. Immunol. 153:4853.