Challenges and trends in bioseparations

Journal of Chemical Technology and Biotechnology

Volumn 83, Issue 2, 2008, Pages 117-120

  Asenjo, Juan A ^a   Andrews, Barbara A ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Bioseparations; Challenges; Future trends; Recombinant proteins; Separation processes

Indexed keywords

MATHEMATICAL MODELS; MOLECULAR BIOLOGY; OPTIMIZATION; PHYSICAL CHEMISTRY; PROTEINS; SEPARATION;

BIOSEPARATIONS; CHROMATOGRAPHIC SEPARATIONS; RECOMBINANT PROTEINS;

CHROMATOGRAPHY;

MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

CHROMATOGRAPHY; MATHEMATICAL MODELS; MOLECULAR BIOLOGY; OPTIMIZATION; PHYSICAL CHEMISTRY; PROTEINS; SEPARATION;

ADSORPTION; BIOSEPARATION; CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MATHEMATICAL MODEL; MOLECULAR BIOLOGY; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; REVERSE MICELLE; SEPARATION TECHNIQUE; SHORT SURVEY;

EID: 38849101542     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.1851     Document Type: Short Survey

References (24)

1. Asenjo JA, New separation methods in biotechnology, in ECB6: Proceedings of the 6th European Congress on Biotechnology, ed. by Alberghina L, Frontali L, Sensi P. Elsevier, Amsterdam, pp. 503-510 (1994).
2. Asenjo JA, Leser E and Andrews BA, New Perspectives in Bioseparations: Separation Technology in the Next Ten Years, ed. by Garside J. Institution of Chemical Engineers, Rugby, UK, pp. 97-131 (1994).
3. Brors A and Kroner KH, Electrically enhanced cross flow filtration of biosuspensions, in Harnessing Biotechnology for the 21st Century, ed. by Ladisch MR and Bose A. ACS Conference Proceedings Series, Washington, DC, pp. 254-257 (1992).
4. Brors A, Kroner KH and Deckwer WD, Cross flow electro-filtration of disrupted microbial cells, in ECB6: Proceedings of the 6th European Congress on Biotechnology, ed. by Alberghina L, Frontali L and Sensi P. Elsevier, Amsterdam, pp. 503-510 (1994).
5. Hagen AJ, Hatton TA and Wang DIC, Protein refolding in reversed micelles. Biotechnol Bioeng 35:955-965 (1990).
6. Matzke SF, Creagh AL, Haynes CA, Prausnitz JM and Blanch ???HW, Mechanisms of protein solubilization in reverse micelles. Biotechnol Bioeng 40:91-102 (1992).
7. Andrews BA, Pyle DL and Asenjo JA, The effect of pH and ionic strength on the partitioning of four proteins in reverse micelle systems. Biotechnol Bioeng 43:1052-1058 (1994).
8. van Buel MJ, van der Wielen LAM, Meester R, Verpoorte R and Luyben KChAA, Modelling of centrifugal partition chromatography, in ECB6: Proceedings of the 6th European Congress on Biotechnology, ed. by Alberghina L, Frontali L and Sensi P. Elsevier, Amsterdam, pp. 511-514 (1994).
9. Champluvier B and Kula MR, Dye-ligand membranes as selective adsorbents for rapid purification of enzymes: a case study. Biotechnol Bioeng 40:33-40 (1992).
10. Champluvier B and Kula MR, Microfiltration membranes as pseudo-affinity adsorbents: modification and comparison with gel beads. J Chromatogr 539:315-325 (1991).
11. Clonis Y, Atkinson A, Bruton C and Lowe C, Reactive Dyes in Protein and Enzyme Technology. Macmillan, Basingstoke, UK (1987).
12. Clonis Y, Process affinity chromatography, in Separation Processes in Biotechnology, ed. by Asenjo JA. Marcel Dekker, New York, pp. 401-445 (1990).
13. Albertsson PA, Partition of Cell Particles and Macromolecules (3rd edn). Wiley, New York (1986).
14. Walter H, Brooks DE and Fisher D, Partitioning in Aqueous Two-Phase Systems: Theory, Methods, Uses and Applications to Biotechnology. Academic Press, London (1985).
15. Hart RA, Lester PM, Reifsnyder DH, Ogez JR and Builder SE, Large scale, in situ isolation of periplasmic IGF-1 from E. coli. Bio/ Technology 12:1113-1117 (1994).
16. Schmidt A, Ventom AM and Asenjo JA, Partitioning and purification of α-amylase in aqueous two-phase systems. Enzyme Microb Technol 16:131-142 (1994).
17. Pungor E, Afeyan NB, Gordon NF and Cooney CL, Continuous affinity-recycle extraction: a novel protein separation technique. Bio/Technology 5:604 (1987).
18. Rodrigues MI, Zaror CA, Maugeri F and Asenjo JA, Dynamic modelling, simulation and control of continuous adsorption recycle extraction. Chem Eng Sci 47:263-269 (1992).
19. Asenjo JA and Andrews BA, Is there a rational way to purify proteins? From expert systems to proteomics. J Mol Recogn 17:236-247 (2004).
20. Lienqueo ME, Salgado JC and Asenjo JA, An expert system for selection of protein purification processes: experimental validation. J Chem Technol Biotechnol 74:293-299 (1999).
21. Lienqueo ME, Leser EW and Asenjo JA, An expert system for the selection and synthesis of multistep protein separation processes. Comp Chem Eng 20:189-194 (1996).
22. Leser EW and Asenjo JA, The rational design of purification processes for recombinant proteins. J Chromatogr 584:43-57 (1992).
23. Shene C, Andrews BA, Lucero A and Asenjo JA, Mathematical modelling of elution curves for a protein mixture in ion exchange chromatography and for the optimal selection of operational conditions. Biotechnol Bioeng 95:704-713 (2006).
24. Kaltenbrunner O, Giaverinni O, Woehle D and Asenjo JA, Application of chromatographic theory for process characterization towards validation of an ion-exchange operation. Biotechnol Bioeng 98:201-210 (2007).