Tyrosine and serine phosphorylation regulate the conformation and subsequent threonine phosphorylation of the L1 cytoplasmic domain

Biochemical and Biophysical Research Communications

Volumn 389, Issue 2, 2009, Pages 257-264

  Chen, Maxine M ^a   Leland, Hyuma A ^a   Lee, Chia Yao ^a   Silletti, Steve ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

CKII; Conformation; Folding; L1 CAM; Phosphorylation; PKC

Indexed keywords

CASEIN KINASE II; MEMBRANE PROTEIN; PHENYLALANINE; PROTEIN KINASE C ALPHA; PROTEIN L1; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANTIBODIES, PHOSPHO-SPECIFIC; CASEIN KINASE II; CYTOPLASM; EPITOPES; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEURAL CELL ADHESION MOLECULE L1; PHOSPHORYLATION; PROTEIN FOLDING; PROTEIN KINASE C-ALPHA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SERINE; THREONINE; TYROSINE;

EID: 70349312348     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.143     Document Type: Article

References (27)

1. Burden-Gulley S.M., Pendergast M., and Lemmon V. The role of cell adhesion molecule L1 in axonal extension, growth cone motility, and signal transduction. Cell Tissue Res. 290 (1997) 415-422
2. S. Silletti, P. Altevogt, A.M.P. Montgomery, L1 cell adhesion molecule (CD171). CD171 Guide for the 2000 International Workshop in Human Leukocyte Differentiation Antigens and the Online "Protein Reviews on the Web (PROW)" (www.ncbi.nlm.nih.gov/prow), PROW, vol. 1, 2000. pp. 31-37.
3. Fogel M., Gutwein P., Mechtersheimer S., et al. L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet 362 (2003) 869-875
4. Fogel M., Mechtersheimer S., Huszar M., et al. L1 adhesion molecule (CD171) in development and progression of human malignant melanoma. Cancer Lett. 189 (2003) 237-247
5. Daponte A., Kostopoulou E., Kollia P., et al. L1-CAM in ovarian serous neoplasms. Eur. J. Gynaecol. Oncol. 29 (2008) 26-30
6. Silletti S., Yebra M., Perez B., et al. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J. Biol. Chem. 279 (2004) 28880-28888
7. Gavert N., Conacci-Sorrell M., Gast D., et al. L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol. 168 (2005) 633-642
8. Gavert N., Sheffer M., Raveh S., et al. Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res. 67 (2007) 7703-7712
9. Fransen E., Lemmon V., van Camp G., et al. CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. Eur. J. Hum. Genet. 3 (1995) 273-284
10. Kamiguchi H., and Lemmon V. A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone. J. Neurosci. 18 (1998) 3749-3756
11. Schaefer A.W., Kamei Y., Kamiguchi H., et al. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J. Cell Biol. 157 (2002) 1223-1232
12. Schultheis M., Diestel S., and Schmitz B. The role of cytoplasmic serine residues of the cell adhesion molecule L1 in neurite outgrowth, endocytosis and cell migration. Cell. Mol. Neurobiol. 27 (2007) 11-31
13. Gast D., Riedle S., Issa Y., et al. The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies. Oncogene 27 (2008) 1281-1289
14. Cheng L., Lemmon S., and Lemmon V. RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. J. Neurochem. 94 (2005) 1102-1110
15. M. Chen, C.-Y. Lee, H. Leland, et al., Inside-out regulation of L1 conformation, proteolysis and integrin binding in pancreatic cancer cells, Am. J. Pathol., submitted for publication.
16. Silletti S., Mei F., Sheppard D., et al. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J. Cell Biol. 149 (2000) 1485-1502
17. Hlavin M.L., and Lemmon V. Molecular structure and functional testing of human L1CAM: an interspecies comparison. Genomics 11 (1991) 416-423
18. Kamiguchi H., Long K.E., Pendergast M., et al. The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway. J. Neurosci. 18 (1998) 5311-5321
19. Haspel J., and Grumet M. The L1CAM extracellular region: a multi-domain protein with modular and cooperative binding modes. Front. Biosci. 8 (2003) s1210-s1225
20. Herron L.R., Hill M., Davey F., et al. The intracellular interactions of the L1 family of cell adhesion molecules. Biochem. J. 419 (2009) 519-531
21. Tyukhtenko S., Deshmukh L., Kumar V., et al. Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins. Biochemistry 47 (2008) 4160-4168
22. Zhang X., Davis J.Q., Carpenter S., et al. Structural requirements for association of neurofascin with ankyrin. J. Biol. Chem. 273 (1998) 30785-30794
23. Nakata A., and Kamiguchi H. Serine phosphorylation by casein kinase II controls endocytic L1 trafficking and axon growth. J. Neurosci. Res. 85 (2007) 723-734
24. Faissner A., Teplow D.B., Kübler D., et al. Biosynthesis and membrane topography of the neural cell adhesion molecule L1. EMBO J. 4 (1985) 3105-3113
25. Gutwein P., Oleszewski M., Mechtersheimer S., et al. Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells. J. Biol. Chem. 275 (2000) 15490-15497
26. Beer S., Oleszewski M., Gutwein P., et al. Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule. J. Cell Sci. 112 (1999) 2667-2675
27. Mechtersheimer S., Gutwein P., Agmon-Levin N., et al. Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J. Cell Biol. 155 (2001) 661-673