Randomized controlled trial of aspirin and clopidogrel versus aspirin and placebo on markers of smooth muscle proliferation before and after peripheral angioplasty

Journal of Vascular Surgery

Volumn 50, Issue 4, 2009, Pages 861-869

  Wilson, Alasdair M ^a   Brittenden, Julie ^a   Bachoo, Paul ^b   Ford, Isobel ^a   Nixon, Graeme F ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; CLOPIDOGREL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLACEBO; PLATELET DERIVED GROWTH FACTOR; VON WILLEBRAND FACTOR;

ADULT; AGED; ANGIOPLASTY; ANIMAL CELL; ARTERY DISEASE; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CLASSIFICATION; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; LOADING DRUG DOSE; MALE; MONOTHERAPY; NONHUMAN; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; SMOOTH MUSCLE FIBER; THROMBOCYTE ACTIVATION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ANGIOPLASTY, BALLOON; ASPIRIN; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; E-SELECTIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GRAFT OCCLUSION, VASCULAR; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 3; MULTIVARIATE ANALYSIS; MUSCLE, SMOOTH, VASCULAR; PERIPHERAL VASCULAR DISEASES; PLATELET AGGREGATION INHIBITORS; PLATELET-DERIVED GROWTH FACTOR; PROBABILITY; REFERENCE VALUES; STATISTICS, NONPARAMETRIC; TICLOPIDINE;

EID: 70349310078     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2009.06.017     Document Type: Article

References (36)

1. Norgen L., Hiatt W.E., Dormandy J.A., Nehler M.R., Harris K.A., and Fowkes F.G.R. Inter-society consensus for the management of Peripheral Arterial Disease (TASC II). J Vasc Surg 45 (2007) S5A-S67A
2. De Vries S.O., and Hunink M.G. Results of aortic bifurcation grafts for aortoiliac occlusive disease: a meta-analysis. J Vasc Surg 26 (1997) 558-569
3. Chandrasekar B., and Tanguay J.F. Platelets and restenosis. J Am Coll Card 35 (2000) 555-562
4. Roller R.E., Janisch S., Kvas E., Schnedl W.J., Binder B.R., Wojta J., et al. Smooth muscle cell migration promoting activity of plasma predicts restenosis in patients with peripheral arterial occlusive disease undergoing angioplasty. Thromb Haemost 84 (2000) 1113-1116
5. Clowes A.W. Pathologic intimal hyperplasia as a response to vascular injury and reconstruction. In: Rutherford R.B. (Ed). Vascular surgery. 5th ed. (2000), WB Saunders, Philadelphia, PA 408-418
6. Camilleri J.P., Berry C.L., Fiessinger J.N., and Bariety J. Diseases of the arterial wall (1989), Springer-Verlag, Berlin pp. 15-31
7. Robinson M.J., and Cobb M.H. Mitogen-activated protein kinase pathways. Curr Opin in Cell Biol 9 (1997) 180-186
8. Bornfeldt K.E., Raines E.W., Nakano T., Graves L.M., Krebs E.G., and Ross R. Insulin-like growth factor-1 and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signalling pathways that are distinct from those proliferation. J Clin Invest 93 (1994) 1266-1274
9. Koyama H., Olson N.E., Dastvan F.F., and Reidy M.A. Cell replication in the arterial wall: activation of signalling pathway following in vivo injury. Circ Res 82 (1998) 713-721
10. Hu Y., Cheng L., Hochleitner B.W., and Xu Q. Activation of mitogen-activated protein kinases (ERK/JNK) and AP-1 transcription factor in rat carotid arteries after balloon injury. Arterioscler Thromb Vasc Biol 17 (1997) 2808-2816
11. Gennaro G., Menard C., Giasson E., Michaud S.E., Palasis M., Meloche S., et al. Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation. Arterioscler Thromb Vasc Biol 23 (2003) 204-210
12. Johansson S.R., Nilsson J., Hamsten A., and Emanuelsson H. Mitogenic activity in connection with coronary angioplasty. Eur Heart J 14 (1993) 904-909
13. Shirotani M., Yui Y., Hattori R., and Kawai C. Serum from patients with restenosis after percutaneous transluminal coronary angioplasty stimulates proliferation of bovine vascular smooth muscle cells under low extracellular calcium conditions. Jpn Circ J 55 (1991) 634-642
14. Uchida K., Sasahara M., Morigami N., Hazama F., and Kinoshita M. Expression of platelet-derived growth factor B-chain in neointimal smooth muscle cells of balloon injured rabbit femoral arteries. Atherosclerosis 124 (1996) 9-23
15. Roller R.E., Schnedl W.J., and Korninger C. Predicting the risk of restenosis after angioplasty in patients with peripheral arterial disease. Clin Lab 47 (2001) 555-559
16. Hoylaerts M.F. Platelet-vessel wall interactions in thrombosis and restenosis role of von Willebrand factor. Verh K Acad Geneeskd Belg 59 (1997) 161-183
17. Heider P., Wildgruber M.G., Weiss W., Berger H.J., Eckstein H.H., and Wolf O. Role of adhesion molecules in the induction of restenosis after angioplasty in the lower limb. J Vasc Surg 43 (2006) 969-977
18. Kilickap M., Tutar E., Aydintug O., Pamir G., Erol C., Tutkak H., et al. Increase in soluble e-selectin level after PTCA and stent implantation: a potential marker of restenosis. Int J Cardiol 93 (2004) 13-18
19. Mlekusch W., Exner M., Schillinger M., Sabeti S., Mannhalter C., Minar E., et al. E-selectin and restenosis after femoropopliteal angoioplasty: prognostic impact of the Ser128Arg genotype and plasma levels. Thromb Haemost 91 (2004) 171-179
20. Barron M.K., Buda A.J., Lake R.S., and Tenaglia A.N. Intimal hyperplasia after balloon injury is attenuated by blocking selectins. Circulation 96 (1997) 3587-3592
21. Belch J.J.F., Shaw J.W., Kirk G., McLaren M., Robb R., Maple C., et al. The white blood cell adhesion molecule e-selectin predicts restenosis in patients with intermittent claudication undergoing percutaneous transluminal angiolasty. Circulation 95 (1997) 2027-2031
22. Smith C.W. Potential significance of circulating e-selectin. Circulation 95 (1997) 1986-1988
23. Mehta S.R., Yusuf S., Peters R.J., Bertrand M.E., Lewis B.S., Natarajan M.K., et al. Effects of pre-treatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358 (2001) 527-533
24. Abrams H.L., Baum S., and Pentecost M.J. Abrams' angiology: interventional radiology. 2nd ed. (2005), Lippincott Williams and Wilkins, Philadelphia, PA pp. 475-81
25. ACA/AHA 2005 Guidelines for the management of patients with peripheral arterial disease (lower extremityrenalmesentericabdominal aortic): Executive summary. J Am Coll Cardiol 47 (2006) 1255-1258
26. Scottish Intercollegiate Guidelines Network. Diagnosis and management of peripheral arterial disease: a national clinical guideline 89 (2000) 1-41
27. Egan C.G., and Nixon G.F. Endothelin-1 and depolarization-induced differential regulation of cAMP response element-binding protein in proliferating and developing vascular smooth muscle cell. Cell Sig 16 (2004) 1387-1396
28. Short P.E., Williams C.E., Picken A.M., and Hill F.G. Factor VIII related antigen: an improved enzyme immunoassay. Med Lab Sci 39 (1982) 351-355
29. Meiklejohn D.J., Vickers M.A., Morrison E.R., Dijkhuisen R., Moore I., Urbaniak S.J., et al. In vivo platelet activation in atherothrombotic stroke is not determined by polymorphisms of human platelet glycoprotein IIa or Ib. Br J Haem 112 (2001) 621-631
30. Cassar K., Ford I., Greaves M., Bachoo P., and Brittenden J. Randomised clinical trial of the antiplatelet effects of aspirin-clopidogrel combination versus aspirin alone after lower limb angioplasty. Br J Surg 92 (2005) 159-165
31. Moshfegh K., Redondo M., Julmy F., Wuillemin W.A., Gebauer M.U., Haeberli A., et al. Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy. J Am Coll Card 36 (2000) 699-705
32. Leppenan O., Janjic N., Carlsson M.A., Pietras K., Levin M., Vargeese C., et al. Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid injury model. Arterioscler Thromb Vasc Biol 20 (2000) e89-e95
33. Johansen O., Brekke M., Seljeflot I., Semb A.G., and Arnesen H. Blood platelet count and reactivity are associated with restenosis 6 months after coronary angioplasty. Scand Cardiovasc J 38 (2004) 211-215
34. Inoue T., Hoshi K., Yaguchi I., Iwasaki Y., Takayanagi K., and Morooka S. Serum levels of circulating adhesion molecules after coronary angioplasty. Cardiology 91 (1999) 236-242
35. Tsakiris D.A., Tschopl M., Jager K., Haefeli W.E., Wolf F., and Marbet G.A. Circulating cell adhesion molecules and endothelial markers before and after transluminal angioplasty in peripheral arterial occlusive disease. Atherosclerosis 142 (1999) 193-200
36. Rossi E. Increased plasma levels of platelet-derived growth factor (PDGF-BB + PDGF-AB) in patients with never-treated mild essential hypertension. Am J Hypertens 11 (1998) 1239-1243