Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles 5-FU-loaded chitosan/polyethylene glycol microparticles Chuen-Chang Lin and Chun-Hsien Fu

Drug Delivery

Volumn 16, Issue 5, 2009, Pages 274-279

  Lin, Chuen Chang ^a   Fu, Chun Hsien ^a  

^a NATIONAL YUNLIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

5 fluorourical; Chitosan; Controlled release controlled release; Phase inversion; Tripolyphosphate

Indexed keywords

CHITOSAN; FLUOROURACIL; MACROGOL; PHOSPHATE; TRIPOLYPHOSPHATE; ANTINEOPLASTIC AGENT; CROSS LINKING REAGENT; MACROGOL DERIVATIVE; POLYPHOSPHATE; TRIPHOSPHORIC ACID;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED RELEASE FORMULATION; CROSS LINKING; DRUG RELEASE; ENCAPSULATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG FORMULATION; PARTICLE SIZE; PHARMACEUTICS;

ANTINEOPLASTIC AGENTS; CHITOSAN; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; FLUOROURACIL; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYPHOSPHATES; TECHNOLOGY, PHARMACEUTICAL;

EID: 70349308252     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540902987625     Document Type: Article

References (10)

1. Ackland, S.P., Garg, M.B., Dunstan, R.H. (1997). Simultaneous determination of dihydrofluorouracil and 5-fluorouracil in plasma by high-performance liquid chromatography. Anal Biochem. 246, 79-85.
2. Dafeng, C., Gua, J., Liu, W., Fawcett, J.P., Dong, O. (2003). Sensitive liquid chromatographic assay for the simultaneous determination of 5-fluorouracil and its prodrug, tegafur, in beagle dog plasma. J Chromatogr B. 795, 377-382
3. Jiang, W.H., Han, S.J. (1999). The interactions of chitosanpoly( ethylene glycol) in the presence of added salt in water viscosity effect. Eur Polym J. 35, 2079-2085
4. Ko, J.A., Park, H.J., Hwang, S.J., Park, J.B., Lee, J.S. (2002). Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm. 249, 165-174
5. Kolhe, P., Kannan, R.M. (2003). Improvement in ductility of chitosan through blending and copolymerization with PEG: FTIR investigation of molecular interations. Biomacromolecules. 4, 173-180
6. Mi, F.L., Shyu, S.S., Chen, C.T., Lai, J.Y. (2002). Adsorption of indomethacin onto chemically modified chitosan beads. Polymer. 43, 757-765
7. Rao, B.S., Murthy, K.V.R. (2002). Studies on rifampicin release from ethylcellulose coated nonpareil beads. Int J Pharm. 231, 97-106.
8. Shu, X.Z., Zhu, K.J. (2000). A novel approach to prepare tripolyphosphate/ chitosan complex beads for controlled release drug delivery. Int J Pharm. 201, 51-58
9. Shu, X.Z., Zhu, K.J. (2002). The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release. Eur J Pharm Biopharm. 54, 235-243
10. Zhang, M., Li, X.H., Gong, Y.D., Zhao, N.M., Zhang, X.F. 2002. Properties and biocompatibility of chitosan films modified by blending with PEG. Biomaterials. 23, 2641-2648