Angiotensin-converting enzyme genotype affects skeletal muscle strength in elite athletes

Journal of Sports Science and Medicine

Volumn 8, Issue 3, 2009, Pages 410-418

  Costa, Aldo Matos ^a,b,f   Silva, António José ^b,c   Garrido, Nuno Domingos ^b,c   Louro, Hugo ^b,d   Marinho, Daniel Almeida ^a,b   Marques, Mário Cardoso ^a,b   Breitenfeld, Luiza ^e,f  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b RESEARCH CENTER IN SPORTS SCIENCES   (Portugal)

^c UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^d Sports Science Institute of Rio Maior   (Portugal)

^e UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^f CICS   (Portugal)

Author keywords

Genetic polymorphism; Sport performance; Swimming; Triathlon

Indexed keywords

EID: 70349303148     PISSN: None     EISSN: 13032968     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Berk, B.C., Vekshtein, V., Gordon, H.M and Tsuda T. (1989) Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension 13, 305-314.
2. Beunen, G. and Thomis, M. (2004) Gene Powered? Where to Go from Heritability (h2) in Muscle Strength and Power? Exercise and Sport Sciences Reviews 32(4), 148-154.
3. Blanksby, B.A., Gathercole, D.G., Marshall, R.N. (1995) Reliability of ground reaction force data and consistency of swimmers in tumble turn analysis. Journal of Human Movement Studies 28, 193-207.
4. Bosco, C. (1994) La valoración de la fuerza con el test de Bosco. Paidotribo, Barcelona, Spain. Carmelli, D. and Reed, T. (2000) Stability and change in genetic and environmental influences on hand-grip strength in older male twins. Journal of Applied Physiology 89, 1879-1883.
5. Chow, J.W.-C., Hay, J.G., Wilson, B.D., Imel, C. (1984) Turning techniques of elite swimmers. Journal of Sports Science 2(3), 169-182.
6. Costa, A., Silva, A.J., Breitenfeld, L., Marques, M.C., Marinho, D., Garrido, N., Reis, V. and Louro H. (2008) ACE genotype and critical velocity in elite swimmers. Archivos de Medicina del Deporte XXVI(129), 34 (abstract).
7. Crawford, F., Abdullah, L., Schinka, J., Suo, Z., Gold, M., Duara, R. and Mullan, M. (2000) Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease. Neuroscience Letters 280, 215-219.
8. Danser, A.H., Derkx, F.H., Schalekamp, M.A., Hense, H., Riegger, G.A. and Schunkert, H. (1998) Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro) renin levels in humans. Journal of Hypertension 16(6), 853-862.
9. Ellison, K.E., Ingelfinger, J.R., Pivor, M. and Dzau, V.J. (1989) Androgen regulation of rat renal angiotensinogen messenger RNA expression. Journal of Clinical Investigation 83(6), 1941-1945.
10. Fischer, M., Baessler, A. and Schunkert, H. (2002) Renin angiotensin system and gender differences in the cardiovascular system. Cardiovascular Research 53(3), 672-677.
11. Foo, L.H. (2007) Influence of body composition, muscle strength, diet and physical activity on total body and forearm bone mass in Chinese adolescent girls. British Journal of Nutrition 98(6), 1281-1287.
12. Frederiksen, H., Gaist, D., Petersen, H.C., Hjelmborg, J., McGue, M., Vaupel, J.W. and Christensen, K. (2002) Hand grip strength: A phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning. Genetic Epidemiology 23, 110-122.
13. Garfinkel, S. and Cafarelli, E. (1992) Relative changes in maximal force, EMG, and muscle cross-sectional area after isometric training. Medicine & Science in Sports & Exercise 24(11), 1220-1227.
14. Geladas, N.D, Nassis, G.P, Pavlicevic, S. (2005) Somatic and physical traits affecting sprint swimming performance in young swimmers. International Journal of Sports Medicine 26(2), 139-144.
15. Gordon, S.E., Davis, B.S., Carlson, C.J. and Booth, F.W. (2001) ANG II is required for optimal overload-induced skeletal muscle hypertrophy. American Journal of Physiology - Endocrinology and Metabolism 280, E150-E159.
16. Gray, M.O., Long, C.S., Kalinyak, J.E., Li, H.T. and Karliner, J.S. (1998) Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts. Cardiovascular Research 40, 352-363.
17. Haidar, S., Kumar, D., Bassi, R. and Deshmukh, S. (2004) Average Versus Maximum Grip Strength: Which is More Consistent. Journal of Hand Surgery: British volume 29(1), 82-84.
18. Hakkinen, K., Newton, R.U., Gordan, S.E., McCormick, M., Volek, J.S., Nindl, B.C., Gotshalk, L.A., Campbell, W.W., Evans, W.J., Hakkinen, A., Humphries, B.J. and Kraemer, W.J. (1998) Changes in muscle morphology, electromyographic activity and force production characteristics during progressive strength training in young and old men. Journal of Gerontology Series A: Biological Sciences and Medical Sciences 53(6), B415-B423.
19. Hopkinson, N.S., Nickol, A.H., Payne, J., Hawe, E., Man, W.D-C., Moxham, J., Montgomery, H. and Polkey, M.I. (2004) Angiotensin converting enzyme genotype and strength in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 170, 395-399.
20. Jones, D.A. (1992) Strength of skeletal muscle and the effects of training. British Medical Bulletin 48, 592-604.
21. Macarthur, D.G. and North, K.N. (2005) Genes and human elite athletic performance. Human Genetics 116, 331-339.
22. Markovic, G., Dizdar, D., Jukic, I. and Cardinale, M. (2004) Reliability and factorial vality of squad and countermovement jump tests. Journal of Strength and Conditioning Research 18(3), 551-555.
23. Marques, M.C., Tillaar, R., Vescovi, J.D. and González-Badillo J. (2008) Changes in strength and power performance in elite senior female professional volleyball players during the in-season: a case study. Journal of Strength and Conditioning Research 20(3), 563-571.
24. Mathiowetz, V., Weber, K., Volland, G. and Kashman, N. (1984) Reliability and validity of grip and pinch strength evaluations. Journal of Hand Surgery 9(2), 222-226.
25. McBride, T.A. (2006) AT1 receptors are necessary for eccentric training-induced hypertrophy and strength gains in rat skeletal muscle. Experimental Physiology 91, 413-421.
26. McEwan, P.E., Gray, G.A., Sherry, L., Webb, D.J. and Kenyon, C.J. (1998) Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo. Circulation 98, 2765-2773.
27. Millet, G.P., Jaouen, B., Borrani, F., Candau, R. (2002) Effects of concurrent endurance and strength training on running economy and VO2 kinetics. Medicine & Science in Sports & Exercise 34(8), 1351-1359.
28. Montgomery, H., Clarkson, P., Barnard, M., Bell, J., Brynes, A., Dollery, C., Hajnal, J., Hemingway, H., Mercer, D., Jarman, P., Marshall, R., Prasad, K., Rayson, M., Saeed, N., Talmud, P., Thomas, L., Jubb, M., World, M. and Humphries, S. (1999) Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training. Lancet 353(9152), 541-545.
29. Montgomery, H., Clarkson, P., Dollery, C., Prasad, K., Losi, M., Hemingway, H., Statters, D., Jubb, M., Girvain, M., Varnava, A., World, M., Deanfield, J., Talmud, P., McEwan, J., McKenna, W. and Humphries, S. (1997) Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 96, 741-747.
30. Moran, C., Scott, R., Wilson, R., Georgiade, E., Goodwin, W., Wolde, B. and Pitsiladis Y. (2004) Increased frequency of an ACE polymorphism in Ethiopian elite marathon runners. Medicine & Science in Sports & Exercise 36(5), S259.
31. Myerson, S., Montgomery, H.E., Whittingham, M., Jubb, M., World, M.J., Humphries, S.E. and Pennell, D.J. (2001) Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: a randomized controlled trial with losartan. Circulation 103, 226-230.
32. Narici, M.V., Roi, G.S., Landoni, L., Minetti, A.E. and Cerretelli, P. (1989) Changes in force, cross sectional área and neural activation during strengh training and detraining of the human quadricepts. European Journal of Applied Physiology 59, 310-319.
33. Nazarov, I., Woods, D., Montgomery, H., Shneider, O., Kazakov, V., Tomilin, N. and Rogozkin, V. (2001) The angiotensin converting enzyme I/D polimorphism in Russion athletes. European Journal of Human Genetics 9(10), 797-801.
34. Nickenig, G., Baumer, A.T., Grohe, C., Kahlert, S., Strehlow, K., Rosenkranz, S., Stäblein, A., Beckers, F., Smits, J.F., Daemen, M.J., Vetter, H. and Böhm, M. (1998) Estrogen modulates AT1 receptor gene expression in vitro and in vivo. Circulation 97, 2197-2201.
35. O'Donnell, C.J., Lindpaintner, K., Larson, M.G., Rao, V.S., Ordovas J.M., Schaeder E.J., Myers, R.H. and Levy, D. (1998) Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 97, 1766-1772.
36. Pescatello, L., Kostek, M., Gordish-dressman, H., Thompson, P., Seip, R., Price, T., Angelopoulos, T., Clarkson, P., Gordon, P., Moyna, N., Visich, P., Zoeller, R., Devaney, J. and Hoffman, E. (2006) ACE ID genotype and the muscle strength and size response to unilateral resistance training. Medicine & Science in Sports & Exercise 38(6), 1074-1081.
37. Proudler, A.J., Ahmed, A.I., Crook, D., Fogelman, I., Rymer, J.M., Stevenson, J. (1995) Hormone replacement therapy and serum angiotensin converting-enzyme activity in postmenopausal women. Lancet 346 (8967), 89-90.
38. Rankinen, T., Bray, M.S., Hagberg, J.M., Perusse, L., Roth, S.M., Wolfarth, B. and Bouchard, C. (2006) The human gene map for performance and health-related fitness phenotypes: the 2005 update. Medicine & Science in Sports & Exercise 38, 1863-1888.
39. Rattigan, S., Dora, K., Tong, A. and Clark, M. (1996) Perfused skeletal muscle contraction and metabolism improved by angiotensin II-mediated vasoconstriction. American Journal of Physiology 271, 96-103.
40. Reed, T., Fabsitz, R.R., Selby, J.V. and Carmelli, D. (1991) Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69. Annals Human Biology 18, 425-432.
41. Reneland, R., and Lithell, H. (1994) Angiotensin-converting enzyme in human skeletal muscle: A simple in vitro assay of activity in needle biopsy specimens. Scandinavian Journal of Clinical and Laboratory Investigation 54, 105-111.
42. Rieder, M., Taylor, S., Clark, A. and Nickerson, D. (1999) Sequence variation in the human angiotensin converting enzyme. Nature Genetics 22, 59-62.
43. Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P. and Soubrier, F. (1990) An insertion/deletion polymorphism in the variance of serum enzyme levels. Journal of Clinical Investigation 86, 1343-1346.
44. Roesch, D.M., Tian, Y., Zheng, W., Shi, M., Verbalis, J.G. and Sandberg, K. (2000) Estradiol attenuates angiotensin induced aldosterone secretion in ovariectomized rats. Endocrinology 141(12), 4629-4636.
45. Ross, W.D. and Marfell-Jones, M.J. (1991) Kinanthropometry. In: Physiological testing of the high-performance athlete. Eds: MacDougall, J.D., Wenger, H.A. and Green, H.J. Champaign, Illinois: Human Kinetics Books, 223-308.
46. Sadoshima, J., Xu, Y., Slayter, H.S. and Izumo, S. (1993) Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75, 977-984.
47. Saxena, P.R. (1992) Interaction between the renin-angiotensin-aldosterone and sympathetic nervous systems. Journal of Cardiovascular Pharmacology 19, S80-S88.
48. Schunkert, H., Danser, A.H., Hense, H.W., Derkx, F.H., Kurzinger, S. and Riegger, G.A. (1997) Effects of estrogen replacement therapy on the renin-angiotensin system in post-menopausal women. Circulation 95, 39-45.
49. Seeman, E., Hopper, J.L., Young, N.R., Formica, C., Goss, P. and Tsalamandris, C. (1996) Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study. American Journal of Physiology Endocrinology and Metabolism 270, E320-E327.
50. Serresse, O., Ama, P.F., Simoneau, J.A., Lortie, G., Bouchard, C. and Boulay, M.R. (1989) Anaerobic performances of sedentary and trained subjects. Canadian Journal of Sport Sciences 14(1), 146-152.
51. Silva, G.J., Moreira, E.D., Pereira, A.C., Mill, J.G., Krieger, E.M. and Krieger J.E. (2006) ACE gene dosage modulates pressure-induced cardiac hypertrophy in mice and men. Physiological Genomics 27, 237-244.
52. Silva, A.J., Costa, A.M., Oliveira, P. M., Reis V. M., Saavedra, J., Pearl, J., Rouboa, A., Marinho, A.D. (2007) The use of neural network technology to model swimming performance. Journal of Sports Science and Medicine 6, 117-125.
53. Thomis, M.A., Huygens, W., Heuninckx, S., Chagnon, M., Maes, H.H., Claessens, A., Vlietinck, R., Bouchard, C. and Beunen G. P. (2004) Exploration of myostatin polymorphism and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training. European Journal of Applied Physiology 92, 267-274.
54. Tiainen, K., Sipila, S., Alen, M., Heikkinen, E., Kaprio, J., Koskenvuo, M., Tolvanen, A., Pajala, S. and Rantanen, T. (2004) Heritability of maximal isometric muscle strength in older female twins. Journal of Applied Physiology 96, 173-180.
55. Tiret, L., Visvikis, B.R.S., Breda, C. and Corvolt, P. (1992) Evidence, from Combined Segregation and Linkage Analysis, That a Variant of the Angiotensin I-converting Enzyme (ACE) Gene Controls Plasma ACE Levels. American Journal of Human Genetics 51, 197-205.
56. Tsianos, G., Sanders, J., Dhamrait, S., Humphries, S., Grant, S. and Montgomery, H. (2004) The ACE gene polimorphism and elite endurance swimming. European Journal of Applied Physiology 93(3), 360-362.
57. Walsh, P.S., Metzger, D.A. and Higuchi, R. (1991) Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 10(4), 506-513.
58. Weiss, L.W., Relyea, G.E., Ashley, C.D. and Propst, R.C. (1997) Using velocity-spectrum squats and body composition to predict standing vertical jump ability. Journal of Strength and Conditioning Research 11(1), 14-20.
59. Westerkamp, C.M. and Gordon, S.E. (2005) Angiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 289, R1223-R1231.
60. Williams, A.G., Day, S.H., Folland, J.P., Gohlke, P., Dhamrait, S. and Montgomery, H.E. (2005) Circulating angiotensin converting enzyme activity is correlated with muscle strength. Medicine & Science in Sports & Exercise 37, 944-948.
61. Williams, A. G., Rayson, M.P., Jubb, M., World, M., Woods, D.R., Hayward, M., Martin, J., Humphries, S.E. and Montgomery, H.E. (2000). The ACE gene and muscle performance. Nature 403(Fev), 614.
62. Woods, D., Hickman, M., Jamshidi, Y., Brull, D., Vassiliou, V., Jones, A., Humphries, S. and Montgomery, H. (2001) Elite swimmers and D allele of the ACE I/D polymorphism. Human Genetics 108(3), 230-232.
63. Woods, D.R., Brull, D. and Montgomery, H.E. (2000) Endurance and the ACE I/D polymorphism. Science Progress 83(4), 317-336.
64. Zampagni M.L, Casino, D., Benelli, P., Visani, A., Marcacci, M., De Vito, G. (2008) Anthropometric and strength variables to predict freestyle performance times in elite master swimmers. Journal of Strength Conditioning Research 22(4), 1298-307.