ACE gene dosage modulates pressure-induced cardiac hypertrophy in mice and men

Physiological Genomics

Volumn 27, Issue 3, 2006, Pages 237-244

  Silva, Gustavo J J ^a   Moreira, Edson D ^a   Pereira, Alexandre C ^a   Mill, Jose G ^b   Krieger, Eduardo M ^a   Krieger, Jose E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

Author keywords

Angiotensin converting enzyme polymorphism; Hypertension; Pressure overload; Renin angiotensin system

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME BLOOD LEVEL; GENE DISRUPTION; GENE DOSAGE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC ENGINEERING; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE PRESSURE; HUMAN; HUMAN EXPERIMENT; MALE; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYSTOLIC BLOOD PRESSURE; TISSUE LEVEL; ANIMAL; BLOOD; BLOOD PRESSURE; BRAZIL; C57BL MOUSE; FEMALE; GENETIC POLYMORPHISM; GENETICS; HEART LEFT VENTRICLE HYPERTROPHY; MIDDLE AGED; PATHOPHYSIOLOGY;

MUS;

ADULT; ANIMALS; BLOOD PRESSURE; BRAZIL; FEMALE; GENE DOSAGE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; RENIN-ANGIOTENSIN SYSTEM;

EID: 34247155585     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00023.2006     Document Type: Article

References (52)

1. 1999 World Health Organization-International Society of Hypertension Guidelines Subcommittee. Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. J Hypertens 17: 151-183, 1999.
2. Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439: 851-855, 2006.
3. Baker KM, Chernin MI, Wixson SK, Aceto JF. Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats. Am J Physiol Heart Circ Physiol 259: H324-H332, 1990.
4. Buikema H, Pinto YM, Rooks G, Grandjean JG, Schunkert H, van Gilst WH. The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences in human arteries. Eur Heart J 17: 787-794, 1996.
5. Costerousse O, Danilov S, Alhenc-Gelas F. Genetics of angiotensin I-converting enzyme. Clin Exp Hypertens 19: 659-669, 1997.
6. Dahlof B. The importance of the renin-angiotensin system in reversal of left ventricular hypertrophy. J Hypertens Suppl 11: S29-S35, 1993.
7. Danser AH, Derkx FH, Hense HW, Jeunemaitre X, Riegger GA, Schunkert H. Angiotensinogen (M235T) and angiotensin-converting enzyme (I/D) polymorphisms in association with plasma renin and prorenin levels. J Hypertens 16: 1879-1883, 1998.
8. Danser AH, Schalekamp MA. Is there an internal cardiac renin-angiotensin system? Heart 76: 28-32, 1996.
9. Danser AH, Schalekamp MA, Bax WA, van den Brink AM, Saxena PR, Riegger GA, Schunkert H. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation 92: 1387-1388, 1995.
10. Danser AH, van Kats JP, Admiraal PJ, Derkx FH, Lamers JM, Verdouw PD, Saxena PR, Schalekamp MA. Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension 24: 37-48, 1994.
11. Dellgren G, Eriksson MJ, Blange I, Brodin LA, Radegran K, Sylven C. Angiotensin-converting enzyme gene polymorphism influences degree of left ventricular hypertrophy and its regression in patients undergoing operation for aortic stenosis. Am J Cardiol 84: 909-913, 1999.
12. Devereux RB, Dahlof B, Gerdts E, Boman K, Nieminen MS, Papademetriou V, Rokkedal J, Harris KE, Edelman JM, Wachtell K. Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the losartan intervention for endpoint reduction in hypertension (LIFE) trial. Circulation 110: 1456-1462, 2004.
13. Dzau VJ. Cell biology and genetics of angiotensin in cardiovascular disease. J Hypertens Suppl 12: S3-S10, 1994.
14. Evangelista FS, Krieger JE. The influence of ACE on exercise training-induced cardiac hypertrophy in mice: a gene dosage study. Physiol Genomics 27: 231-236, 2006.
15. Evans AE, Poirier O, Kee F, Lecerf L, McCrum E, Falconer T, Crane J, O'Rourke DF, Cambien F. Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. QJM 87: 211-214, 1994.
16. Graciano ML, Cavaglieri Rde C, Delle H, Dominguez WV, Casarini DE, Malheiros DM, Noronha IL. Intrarenal renin-angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. J Am Soc Nephrol 15: 1805-1815, 2004.
17. Harada K, Komuro I, Shiojima I, Hayashi D, Kudoh S, Mizuno T, Kijima K, Matsubara H, Sugaya T, Murakami K, Yazaki Y. Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation 97: 1952-1959, 1998.
18. Hoffmann S, Krause T, van Geel PP, Willenbrock R, Pagel I, Pinto YM, Buikema H, van Gilst WH, Lindschau C, Paul M, Inagami T, Ganten D, Urata H. Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy. J Mol Med 79: 601-608, 2001.
19. Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet 36: 949-951, 2004.
20. Kim HS, Lee MM, Oh BH, Kim KI, Han KH, Park SK, Sohn DW, Yoo KY, Park YB, Choi YS, Lee YW. Synergistic effect of angiotensin-converting enzyme and angiotensinogen gene on cardiac hypertrophy. Int J Cardiol 72: 151-161, 2000.
21. Kim HS, Maeda N, Oh GT, Fernandez LG, Gomez RA, Smithies O. Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem 274: 14210-14217, 1999.
22. Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, Smithies O. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 375: 146-148, 1995.
23. Krege JH, Kim HS, Moyer JS, Jennette JC, Peng L, Hiller SK, Smithies O. Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension 29: 150-157, 1997.
24. Lachurie ML, Azizi M, Guyene TT, Alhenc-Gelas F, Menard J. Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects. Circulation 91: 2933-2942, 1995.
25. Lechin M, Quinones MA, Omran A, Hill R, Yu QT, Rakowski H, Wigle D, Liew CC, Sole M, Roberts R, and Marian AJ. Angiotensin-I converting enzyme genotypes and left ventricular hypertrophy in patients with hypertrophic cardiomyopathy. Circulation 92: 1808-1812, 1995.
26. Lessa I, Fonseca J. [Race, compliance to treatment and/or consultation and control of arterial hypertension]. Arq Bras Cardiol 68: 443-449, 1997.
27. Mazzolai L, Nussberger J, Aubert JF, Brunner DB, Gabbiani G, Brunner HR, Pedrazzini T. Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension 31: 1324-1330, 1998.
28. McKenzie K, Crowcroft NS. Describing race, ethnicity, and culture in medical research. BMJ 312: 1054, 1996.
29. Morgan HE, Baker KM. Cardiac hypertrophy. Mechanical, neural, and endocrine dependence. Circulation 83: 13-25, 1991.
30. Murphey LJ, Gainer JV, Vaughan DE, Brown NJ. Angiotensin- converting enzyme insertion/deletion polymorphism modulates the human in vivo metabolism of bradykinin. Circulation 102: 829-832, 2000.
31. Ortlepp JR, Breithardt O, Ohme F, Hanrath P, Hoffmann R. Lack of association among five genetic polymorphisms of the renin-angiotensin system and cardiac hypertrophy in patients with aortic stenosis. Am Heart J 141: 671-676, 2001.
32. Pereira AC, Morandini Filho AA, Heimann AS, Rabak ET, Vieira AP, Mota GF, Krieger JE. Serum angiotensin converting enzyme activity association with the I/D polymorphism in an ethnically admixtured population. Clin Chim Acta 360: 201-204, 2005.
33. Pereira AC, Mota GA, Bensenor I, Lotufo PA, Krieger JE. Effect of race, genetic population structure, and genetic models in two-locus association studies: clustering of functional renin-angiotensin system gene variants in hypertension association studies. Braz J Med Biol Res 34: 1421-1428, 2001.
34. Pereira AC, Mota GF, Cunha RS, Herbenhoff FL, Mill JG, Krieger JE. Angiotensinogen 235T allele "dosage" is associated with blood pressure phenotypes. Hypertension 41: 25-30, 2003.
35. Perry GJ, Mori T, Wei CC, Xu XY, Chen YF, Oparil S, Lucchesi P, Dell'Italia LJ. Genetic variation in angiotensin-converting enzyme does not prevent development of cardiac hypertrophy or upregulation of angiotensin II in response to aortocaval fistula. Circulation 103: 1012-1016, 2001.
36. Pfeffer MA, Fischer TA, Pfeffer MA. Angiontensin-converting enzyme inhibition and ventricular remodeling after myocardial infarction. Ann Rev Physiol 57: 805-826, 1995.
37. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86: 1343-1346, 1990.
38. Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 73: 413-423, 1993.
39. Sayed-Tabatabaei FA, Oostra BA, Isaacs A, van Duijn CM, Witteman JC. ACE polymorphisms. Circ Res 98: 1123-1133, 2006.
40. Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. J Clin Invest 86: 1913-1920, 1990.
41. Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, Maner S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, Reiner A, Gilliam TC, Trask B, Patterson N, Zetterberg A, Wigler M. Large-scale copy number polymorphism in the human genome. Science 305: 525-528, 2004.
42. Smithies O, Kim HS. Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci USA 91: 3612-3615, 1994.
43. Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. 1949 Ann Noninvasive Electrocardiol 6: 343-368, 2001.
44. Sumida Y, Umemura S, Tamura K, Kihara M, Kobayashi S, Ishigami T, Yabana M, Nyui N, Ochiai H, Fukamizu A, Miyazaki H, Murakami K, Ishii M. Increased cardiac angiotensin II receptors in angiotensinogen-deficient mice. Hypertension 31: 45-49, 1998.
45. Takahashi N, Hagaman JR, Kim HS, Smithies O. Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system. Endocrinology 144: 2184-2190, 2003.
46. Tian XL, Pinto YM, Costerousse O, Franz WM, Lippoldt A, Hoffmann S, Unger T, Paul M. Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats. Hum Mol Genet 13: 1441-1450, 2004.
47. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 51: 197-205, 1992.
48. Ueda S, Elliott HL, Morton JJ, Connell JM. Enhanced pressor response to angiotensin I in normotensive men with the deletion genotype (DD) for angiotensin-converting enzyme. Hypertension 25: 1266-1269, 1995.
49. Van Kats JP, Methot D, Paradis P, Silversides DW, Reudelhuber TL. Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice. Direct and indirect effects of angiotensin II on the heart. J Biol Chem 276: 44012-44017, 2001.
50. Weber KT, Sun Y, Guarda E. Structural remodeling in hypertensive heart disease and the role of hormones. Hypertension 23: 869-877, 1994.
51. WHO MONICA Project Principal Investigators. World Health Organization MONICA Project (monitoring trends, and determinants in cardiovascular disease): a major international collaboration. J Clin Epidemiol 41: 105-114, 1988.
52. Xiao HD, Fuchs S, Campbell DJ, Lewis W, Dudley SC Jr, Kasi VS, Hoit BD, Keshelava G, Zhao H, Capecchi MR, and Bernstein KE. Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. Am J Pathol 165: 1019-1032, 2004.