Unusual base-catalyzed exchange in the synthesis of deuterated PF-2413873

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 52, Issue 10, 2009, Pages 435-442

  Rozzey, Stuart J ^a   Fray, M Jonathan ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Base catalysis; Deuterium exchange; Platinum catalysis; Progesterone receptor antagonist; Pyrazole; Sulfone

Indexed keywords

AROMATIC COMPOUNDS; DEUTERIUM; PLATINUM COMPOUNDS; POTASSIUM COMPOUNDS; SODIUM HYDROXIDE;

BASE CATALYSIS; BASE CATALYZED; BIOANALYTICAL; CYCLOPROPYL; DEUTERIUM EXCHANGE; PLATINUM CATALYSE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR ANTAGONIST; PYRAZOLES; RECEPTOR ANTAGONISTS;

CATALYSIS;

(4 [3 CYCLOPROPYL 1 (METHANESULFONYLMETHYL) 5 METHYL 1H PYRAZOL 4 YL]OXY 2,6 DIMETHYLBENZONITRILE; BASE; DEUTERIUM OXIDE; HYDROGEN; METHYL GROUP; OXIDE; PF 2413873; PHENOL DERIVATIVE; PLATINUM DERIVATIVE; PYRAZOLE DERIVATIVE; SODIUM HYDROXIDE; SULFIDE; SULFONE; UNCLASSIFIED DRUG;

ALKYLATION; ANALYTIC METHOD; ARTICLE; ASSAY; CATALYSIS; HEATING; OXIDATION; SYNTHESIS;

EID: 70349286046     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1657     Document Type: Article

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