Do pediatric patients with septic shock benefit from steroid therapy? A critical appraisal of "low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock" by Oppert et al. (Crit Care Med 2005; 33:2457-2464)

Pediatric Critical Care Medicine

Volumn 8, Issue 2, 2007, Pages 174-176

  Van Schaik, Sandrijn M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adrenal insufficiency; Review; Sepsis; Shock; Steroids

Indexed keywords

CORTICOSTEROID; DOPAMINE; HYDROCORTISONE; NORADRENALIN;

CASE REPORT; CENTRAL VENOUS CATHETER; CONTINUOUS INFUSION; DRUG DOSE REDUCTION; FEMALE; HUMAN; HYPOTENSION; LOW DRUG DOSE; MORTALITY; OXYGEN THERAPY; PNEUMONIA; PRIORITY JOURNAL; REVIEW; SCHOOL CHILD; SEPSIS; SEPTIC SHOCK;

EID: 34147113760     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PCC.0000257037.10815.C9     Document Type: Article

References (16)

1. Oppert M, Schindler R, Husung C, et al: Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005; 33:2457-2464
2. Guyatt GH, Sackett DL, Cook DJ: Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA 1993; 270:2598-2601
3. Guyatt GH, Sackett DL, Cook DJ: Users' guides to the medical literature. II. How to use an article about therapy or prevention. B. What were the results and will they help me in caring for my patients? Evidence-Based Medicine Working Group. JAMA 1994; 271:59-63
4. Vanhorebeek I, Langouche L, Van den Berghe G: Glycemic and nonglycemic effects of insulin: How do they contribute to a better outcome of critical illness? Curr Opin Crit Care 2005; 11:304-311
5. Annane D, Bellissant E, Bollaert PE, et al: Corticosteroids for severe sepsis and septic shock: A systematic review and meta-analysis. BMJ 2004; 329:480
6. Lopez A, Lorente JA, Steingrub J, et al: Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock. Crit Care Med 2004; 32:21-30
7. Annane D, Sebille V, Charpentier C, et al: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288:862-871
8. Keh D, Boehnke T, Weber-Cartens S, et al: Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: A double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003; 167:512-520
9. Reinhart K, Wiegand-Lohnert C, Grimminger F, et al: Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 1996; 24:733-742
10. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
11. Annane D, Sebille V, Troche G, et al: A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283:1038-1045
12. Hatherill M, Tibby SM, Hilliard T, et al: Adrenal insufficiency in septic shock. Arch Dis Child 1999; 80:51-55
13. Pizarro CF, Troster EJ, Damiani D, et al: Absolute and relative adrenal insufficiency in children with septic shock. Crit Care Med 2005; 33:855-859
14. Markovitz BP, Goodman DM, Watson RS, et al: A retrospective cohort study of prognostic factors associated with outcome in pediatric severe sepsis: What is the role of steroids? Pediatr Crit Care Med 2005; 6:270-274
15. Carcillo JA, Fields AI: Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med 2002; 30:1365-1378
16. Briegel J, Forst H, Haller M, et al: Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study. Crit Care Med 1999; 27:723-732