Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 11, 2009, Pages 2287-2294

  Fitzpatrick, Paul A ^a   Guinan, Anthony F ^a   Walsh, Tony G ^a   Murphy, Ronan P ^a   Killeen, Maria T ^a   Tobin, Nicholas P ^a   Pierotti, Adrian R ^b   Cummins, Philip M ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

Author keywords

Endothelium; Laminar shear stress; NADPH oxidase; Neprilysin; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN II; CATALASE; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COW; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE REPRESSION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LAMINAR FLOW; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SHEAR STRESS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ANIMALS; CATTLE; DOWN-REGULATION; ENDOTHELIAL CELLS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; NADPH OXIDASE; NEPRILYSIN; PROTEIN-TYROSINE KINASES; REACTIVE OXYGEN SPECIES; STRESS, MECHANICAL;

BOVINAE;

EID: 70349272187     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.05.011     Document Type: Article

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