Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates

FEBS Journal

Volumn 276, Issue 19, 2009, Pages 5678-5688

  Bussink, Anton P ^a   Verhoek, Marri ^a   Vreede, Jocelyne ^b   Ghauharali Van Der Vlugt, Karen ^a   Donker Koopman, Wilma E ^a   Sprenger, Richard R ^a   Hollak, Carla E ^c   Aerts, Johannes M F G ^a   Boot, Rolf G ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Chitinase; Chitotriosidase; Gaucher disease; Molecular dynamics simulation; Single nucleotide polymorphism

Indexed keywords

CHITOTRIOSIDASE; HYMECROMONE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME POLYMORPHISM; GENE FREQUENCY; GENE MUTATION; GENE STRUCTURE; GLYCOSYLATION; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ALLELES; AMINO ACID SUBSTITUTION; BASE SEQUENCE; DNA PRIMERS; GAUCHER DISEASE; GENE FREQUENCY; GLYCOSYLATION; HEXOSAMINIDASES; HUMANS; HYMECROMONE; MODELS, MOLECULAR; NETHERLANDS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRISACCHARIDES; UMBELLIFERONES;

EID: 70349246708     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07259.x     Document Type: Article

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