Changes in the balance between proliferation and apoptosis during the progression of malignancy in thyroid tumours

European Journal of Histochemistry

Volumn 53, Issue 2, 2009, Pages 65-71

  Cvejic, Dubravka ^a   Selemetjev, S ^a   Savin, S ^a   Paunovic, I ^b   Tatic, S ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Anaplastic carcinoma; Apoptosis; Bax; Bcl 2; Papillary carcinoma; Papillary microcarcinoma; Proliferation; Thyroid

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; BAX PROTEIN, HUMAN; CYCLINE;

ANAPLASTIC CARCINOMA; APOPTOSIS; ARTICLE; CANCER DIAGNOSIS; CANCER GROWTH; CELL ACTIVITY; CELL DEATH; CELL PROLIFERATION; CLINICAL FEATURE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; NICK END LABELING; PAPILLARY CARCINOMA; PROTEIN EXPRESSION; THYROID GLAND; THYROID TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; THYROID NEOPLASMS;

EID: 70349246656     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: 10.4081/ejh.2009.65     Document Type: Article

References (37)

1. Aksoy M, Giles Y, Kapran Y, Terzioglu T, Tezelman S. Expression of Bcl-2 in papillary thyroid cancers and its prognostic value. Acta Chir Belg 2005;105:644-648 (Pubitemid 43080978)
2. Aldinger KA, Samaan NA, Ibanez M, Hill CS Jr. Anaplastic carcinoma of the thyroid: a review of 84 cases of spindle and giant cell carcinoma of the thyroid. Cancer 1978;41:2267-2275 (Pubitemid 8370197)
3. Baloch ZW, Li Volsi VA. Microcarcinoma of the thyroid. Adv Anat Pathol 2006;13:69-75.
4. Branet F, Brousset P, Krajewski S, Schlaifer D, Selves J, Reed JC, et al. Expression of the cell death-inducing gene Bax in carcinomas developed from the follicular cells of the thyroid gland. J Clin Endocrinol Metab 1996;81:2726-2730 (Pubitemid 26240302)
5. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 2003;7:249-257 (Pubitemid 37372044)
6. Cvejic D, Selemetjev S, Savin S, Paunovic I, Petrovic I, Tatic S. Apoptosis and proliferation related molecules (Bcl-2, Bax, p53, PCNA) in papillary microcarcinoma versus papillary carcinoma of the thyroid. Pathology 2008;40:475-480 (Pubitemid 351950881)
7. Farid P, Gomb SZ, Peter I, Szende B. Bcl-2, p53 and bax in thyroid tumors and their relation to apoptosis. Neoplasma 2001;48:299-301. (Pubitemid 32802442)
8. Gilliland FD, Hunt WC, Morris DM, Key CR. Prognostic factors for thyroid carcinoma. A population-based study of 15,698 cases from Surveillance, Epidemiology and END Results (SEER) program 1973-1991. Cancer 1997;79:564-573
9. Gross A, McDonell JM, Korsmeyer SJ. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev 1999;13:1899-1911 (Pubitemid 29407357)
10. Guiffrida D, Gharib H. Anaplastic thyroid carcinoma: Current diagnosis and treatment. Annals of Oncology 2000;11:1083-1089 (Pubitemid 30783010)
11. Hedinger C, Williams ED, Sobin LH. Histological typing of thyroid tumours. In: International Histological Classification of Tumours. World Health Organization, 2nd edn. Geneva: Springer-Verlag, 1988;1-66.
12. Hermann S, Sturm I, Mrozek I, Klosterhalfen B, Hauptmann S, Dörken B, Daniel PT. Bax expression in benign and malignant thyroid tumours: dysregulation of wild type p53 is associated with a high Bax and p21 expression in thyroid carcinoma. Int J Cancer 2001;92:805-811.
13. Kirkin V, Joos S, Zörnig M. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 2004;1644:229-249 (Pubitemid 38281277)
14. Letsas KP, Frongou-Lazaridis M, Skyrlas A, Tsatsoulis A, Malamou-Mitsi V. Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesions. Pathology International 2005;55:694-702. (Pubitemid 41726935)
15. Levine AJ, Momand J, Finlay CA. The p53 tumor suppressor gene. Nature 1991;351:453-456
16. Li Volsi VA. Surgical pathology of the thyroid. Philadelphia: WB Saunders 1990;136-172
17. LiVolsi VA. Undifferentiated or anaplastic carcinoma of the thyroid. In: Surgical pathology of the thyroid. Philadelphia: WB Saunders 1990;253-274
18. Manetto V, Lorenzini R, Cordon-Cardo C, Krajewski S, Rosai J, Reed JC, et al. Bcl-2 and Bax expression in thyroid tumours. An immunohistochemical and western blot analysis. Virchow Arch 1997;430:125-130
19. Mazzaferri EL, Jhiang S. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 1994;97:418-428 (Pubitemid 24345593)
20. Mitselou A, Peschos D, Dallas P, Charalabopoulos K, Agnantis N J, Vougiouklakis T. Immunohistochemical analysis of expression of Bcl-2 protein in papillary carcinomas and papillary microcarcinomas of the thyroid gland. Exp Oncol 2004; 26: 282-286. (Pubitemid 44246105)
21. Mizukami Y, Michigishi T, Nonomura A, Noguchi M, Nakamura T. Thyroid carcinoma: clinical, pathologic correlations. Crit Rev Oncol/Hematol 1995;18:67-102.
22. Moore D, Ohene-Fianko D, Garcia B, Chakrabarti S. Apoptosis in thyroid neoplasms: relationship with p53 and Bcl-2 expression. Histopathology 1988;32:35-42.
23. Pelizzo MR, Boschin IM, Toniato A, Piotto A, Bernante P, Pagetta C et al. Papillary thyroid microcarcinoma (PTMC): Prognostic factors, management and outcome in 403 patients. Eur J Surg Oncol 2006;32:1144-1148 (Pubitemid 44774404)
24. Piersanti M, Ezzat S, Asa SL. Controversies in papillary microcarcinoma of the thyroid. Endocrine Pathol 2003;14:183-192
25. Pilotti S, Collini P, Rilke F, Cattoreti G, Del Bo R, Pierotti MA. Bcl-2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland. J Pathol 1994;172:337-342 (Pubitemid 2081586)
26. Pollina L, Pacini F, Fontanini G, Vignati S, Bevilacqua G, Basolo F. Bcl-2, p53 and proliferating cell nuclear antigen expression are related to the degree of differentiation in thyroid carcinomas. Br J Cancer 1996;73:139-143 (Pubitemid 3018597)
27. Reed JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994;124:1-6. (Pubitemid 24054605)
28. Rosai J, Carcangiu ML, De Lellis RA. Tumors of the thyroid gland. In: Atlas of Tumor Pathology, Fascicle 5, 3rd Series, Washington, DC: Armed Forces Institute of Pathology 1992;161-182
29. Roti E, Rossi R, Transforini G, Bertelli F, Ambrosio MR, Busutti L et al. Clinical and histological characteristics of papillary thyroid microcarcinoma: results of a retrospective study in 243 patients. J Clin Endocrinol Metab 2006;91:2171-2178
30. Rubin LI, Philpott Ki, Brooks SF. The cell cycle and cell death. Curr Biol 2003;3:391-394
31. Saltman B, Simgh B, Hedvat CV, Wreesmann VB, Ghossein R. Patterns of expression of cycle/apoptosis genes along the spectrum of thyroid carcinoma progression. Surgery 2006;140: 899-905.
32. Spires JR, Schwartz MR, Miller RH. Anaplastic thyroid carcinoma. Association with differentiated thyroid carcinoma. Arch Otolaryngol Head Neck Surgery 1988;114:40-44
33. Sreelekha TT, Pradeep VM, Vijayalakshmi K, Belthazar A, Chellam VG, Nair MB, et al. In situ apoptosis in the thyroid. Thyroid 2000;10:117-122
34. Van der Laan B, Freeman JL, Tsang RW, Asa SL. The association of well-differentiated thyroid carcinoma with insular or anaplastic thyroid carcinoma: Evidence for dedifferentiation in tumor progression. Endocr Pathol 1993;4:215-221
35. Xu WC, Chen SR, Huang JX, Zheng ZC, Chen LX, Lin JJ, et al. Expression and distribution of S-100 protein, CD83 and apoptosis-related proteins (Fas, FasL and Bcl-2) in thyroid tissues of autoimmune thyroid diseases. Eur J Histochem 2007;51:291-300.
36. Xu W, Li X, Chen S, Huang J, Lin S, Lin J, Li Y, Tan X. Expression and distribution of S-100, CD83 and apoptosis-related proteins (Fas, FasL and Bcl-2) in tissues of thyroid carcinoma. Eur J Histochem 2008;52:153-162
37. Yoshida A, Nakamura Y, Imada T, Asaga T, Shimizu A, Harada M. Apoptosis and proliferative activity in thyroid tumors. Surg Today 1999;29:204-220 (Pubitemid 29119834)