Novel furoxan NO-donor pemetrexed derivatives: design, synthesis, and preliminary biological evaluation

Medicinal Chemistry Research

Volumn 18, Issue 7, 2009, Pages 495-510

  Min, Tao ^a   Yi, Bixin ^a   Zhang, Peng ^a   Liu, Jun ^a   Zhang, Can ^a   Zhou, Huiping ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Drug design; Furoxans; Hybrid; Medicinal chemistry; Pemetrexed

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; FOLIC ACID ANTAGONIST; FURAN DERIVATIVE; FURAZOLIDONE; NITRIC OXIDE DONOR; PEMETREXED;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL LINE; CELL STRAIN A549 1; CELL STRAIN BGC 1; CELL STRAIN HL 60; CELL STRAIN SMMC 1; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG DESIGN; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; LIVER CARCINOMA; LUNG CARCINOMA; PROMYELOCYTIC LEUKEMIA; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 70349245134     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-008-9144-x     Document Type: Article

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