Sensitivity and specificity for detecting basal cell carcinomas in Mohs excisions with confocal fluorescence mosaicing microscopy

Journal of Biomedical Optics

Volumn 14, Issue 3, 2009, Pages

  Gareau, Daniel S ^a   Karen, Julie K ^a   Dusza, Stephen W ^a   Tudisco, Marie ^a   Nehal, Kishwer S ^a   Rajadhyaksha, Milind ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

basal cell carcinoma; confocal fluorescence mosaicing microscopy; Mohs surgery

Indexed keywords

BASAL CELL CARCINOMA; CLINICAL UTILITY; CONFOCAL FLUORESCENCE; CONFOCAL FLUORESCENCE MOSAICING MICROSCOPY; CONFOCAL IMAGE; GOLD STANDARDS; HIGH RESOLUTION; MOHS SURGERY; MOSAICING; NEGATIVE PREDICTIVE VALUE; POSITIVE PREDICTIVE VALUES; PRECLINICAL STUDIES; SEMI-QUANTITATIVE; SENSITIVITY AND SPECIFICITY; SURGICAL EXCISION; SURGICAL PATHOLOGY;

DISEASES; PATHOLOGY; TISSUE; TRANSPLANTATION (SURGICAL);

FLUORESCENCE;

ACRIDINE ORANGE;

ARTICLE; BASAL CELL CARCINOMA; CHEMOSURGERY; CONFOCAL MICROSCOPY; CYTOCHEMISTRY; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; METHODOLOGY; PATHOLOGY; PREDICTION AND FORECASTING; SENSITIVITY AND SPECIFICITY; SKIN TUMOR;

ACRIDINE ORANGE; CARCINOMA, BASAL CELL; HISTOCYTOCHEMISTRY; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOHS SURGERY; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; SKIN NEOPLASMS;

EID: 70349241792     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3130331     Document Type: Article

References (7)

1. M., Rajadhyaksha, G., Menaker, T. J., Flotte, P. J., Dwyer, and S., Gonzalez, " Rapid confocal examination of non-melanoma cancers in skin excisions to potentially guide Mohs micrographic surgery, ", J. Invest. Dermatol., 117, 1137-1143 (2001). eae JIDEAE 0022-202X 10.1046/j.0022-202x.2001. 01524.x
2. D. S., Gareau, Y., Li, B., Huang, Z., Eastman, K. S., Nehal, and M., Rajadhyaksha, " Confocal mosaicing microscopy in Mohs skin excisions: feasibility of rapid surgical pathology, ", J. Biomed. Opt., 13 (5), 054001 (2008). jbo JBOPFO 1083-3668 10.1117/1.2981828
3. Y. P., Patel, K. S., Nehal, I., Aranda, Y., Li, A. C., Halpern, and M., Rajadhyaksha, " Confocal reflectance mosaicing of basal cell carcinomas in Mohs surgical skin excisions, ", J. Biomed. Opt., 12 (3), 034027:1-10 (2007). jbo JBOPFO 1083-3668 10.1117/1.2750294
4. D. S., Gareau, Y. G., Patel, Y., Li, I., Aranda, A. C., Halpern, K. S., Nehal, and M., Rajadhyaksha, " Confocal mosaicing microscopy in skin excisions: A demonstration of rapid surgical pathology, ", J. Microsc., 233 (1), 149-159 (2009). jmi JMICAR 0022-2720
5. Reflectance Confocal Microscopy of Cutaneous Tumors - An Atlas with Clinical, Dermoscopic and Histological Correlations, S. G., Gonzalez, M., Gill, and, A. C., Halpern, Eds., Informa Healthcare, London (2008).
6. D. M., Benson, J., Bryan, A. L., Plant, A. M., Gotto, and L. C., Smith, " Digital imaging fluorescence microscopy: spatial heterogeneity of photobleaching rate constants in individual cells, ", J. Cell Biol., 100, 1309-1323 (1985). jla JCLBA3 0021-9525 10.1083/jcb.100.4.1309
7. See, http://www.dangareau.net/mohs08/index.html.