A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: A novel model for dry-eye disease?

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 9, 2009, Pages 4311-4318

  Puk, Oliver ^a   Esposito, Irene ^a,b   Söker, Torben ^a,c   Löster, Jana ^a   Budde, Birgit ^d,e   Nürnberg, Peter ^d,e   Michel Soewarto, Dian ^a,f   Fuchs, Helmut ^a   Wolf, Eckhard ^g   de Angelis, Martin Hrabé ^a   Graw, Jochen ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; ETHYLNITROSOUREA; FGF10 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CHROMOSOME 13; CONTROLLED STUDY; DRY EYE; EMBRYO; EXON; EYE DEVELOPMENT; FEMALE; FRAMESHIFT MUTATION; GENE MAPPING; GENE SEQUENCE; HARDER GLAND; HETEROZYGOTE; HISTOLOGY; IN SITU HYBRIDIZATION; INTRON; LINKAGE ANALYSIS; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; ORGAN SIZE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SLIT LAMP; SPLICING DEFECT; STOP CODON; AMINO ACID SEQUENCE; ANIMAL; C3H MOUSE; C57BL MOUSE; CHROMOSOME; DISEASE MODEL; EYE MALFORMATION; GENETIC ASSOCIATION; GENETICS; LENS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; RETINA;

AMINO ACID SEQUENCE; ANIMALS; ATROPHY; BASE SEQUENCE; CHROMOSOMES, MAMMALIAN; DISEASE MODELS, ANIMAL; DRY EYE SYNDROMES; ETHYLNITROSOUREA; EYE ABNORMALITIES; FEMALE; FIBROBLAST GROWTH FACTOR 10; GENOME-WIDE ASSOCIATION STUDY; HARDERIAN GLAND; HETEROZYGOTE; IN SITU HYBRIDIZATION; LENS, CRYSTALLINE; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; RETINA;

EID: 70349240422     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3451     Document Type: Article

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