Rational design of improved pharmabiotics

Journal of Biomedicine and Biotechnology

Volumn 2009, Issue , 2009, Pages

  Sleator, Roy D ^a,b   Hill, Colin ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b Institute of Technology Rossa Avenue ^*  (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CARNITINE; PROBIOTIC AGENT; PROLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIUM ADHERENCE; BACTERIUM CULTURE; BIFIDOBACTERIUM BREVE; BIOTECHNOLOGY; DRUG DESIGN; DRUG EFFICACY; ESCHERICHIA COLI; GASTROINTESTINAL TRACT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; LACTOBACILLUS; LACTOBACILLUS DELBRUECKII; LACTOBACILLUS JENSENII; LACTOBACILLUS JOHNSONII; LACTOBACILLUS PARACASEI; LACTOBACILLUS SALIVARIUS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MEDICAL RESEARCH; NONHUMAN; STREPTOCOCCUS GORDONII; ANIMAL; CHEMISTRY; HUMAN; METHODOLOGY; REVIEW;

ANIMALS; BIOTECHNOLOGY; HUMANS; PROBIOTICS;

EID: 70349237033     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2009/275287     Document Type: Article

References (34)

1. http://www.fao.org/es/ESN/Probio/probio.htm
2. Shanahan F., Probiotics: promise, problems, and progress Gastroenterology Hepatology Annual Review 2006 1 41 45
3. Madara J., Building an intestine: architectural contributions of commensal bacteria New England Journal of Medicine 2004 351 16 1685 1686
4. Sleator R. D., Hill C., Pathobiotechnology: using bad bugs to make good bugs better Science Progress 2007 90 1 1 14
5. Sleator R. D., Hill C., Pathobiotechnology: using bad bugs to do good things Current Opinion in Biotechnology 2006 17 2 211 216
6. Sleator R. D., Hill C., Bioengineered Bugs: a pathobiotechnology approach to probiotic research and applications Medical Hypotheses 2007 70 1 167 169
7. Sleator R. D., Hill C., Improving probiotic function using a pathobiotechnology approach Gene Therapy and Molecular Biology 2007 11 2 269 274
8. Sheehan V., Sleator R. D., Fitzgerald G., Hill C., Heterologous expression of BetL, a betaine uptake system, enhances the stress tolerance of Lactobacillus salivarius UCC118 Applied and Environmental Microbiology 2006 72 3 2170 2177
9. Sheehan V. M., Sleator R. D., Hill C., Fitzgerald G. F., Improving gastric transit, gastrointestinal persistence, and therapeutic efficacy of the probiotic strain Bifidobacterium breve UCC2003 Microbiology 2007 153 10 3563 3571
10. Paton A. W., Morona R., Paton J. C., Designer probiotics for prevention of enteric infections Nature Reviews. Microbiology 2006 4 3 193 200
11. Hill C., Cotter P., Sleator R. D., Gahan C. G. M., Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing International Dairy Journal 2002 12 2-3 273 283
12. De Dea Lindner J., Canchaya C., Zhang Z., Exploiting bifidobacterium genomes: the molecular basis of stress response International Journal of Food Microbiology 2007 120 1-2 13 24
13. Sleator R. D., Hill C., Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence FEMS Microbiology Reviews 2002 26 1 49 71
14. Sleator R. D., Gahan C. G. M., Hill C., A postgenomic appraisal of osmotolerance in Listeria monocytogenes Applied and Environmental Microbiology 2003 69 1 1 9
15. Sleator R. D., Gahan C. G. M., Abee T., Hill C., Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28 Applied and Environmental Microbiology 1999 65 5 2078 2083
16. Smiddy M., Sleator R. D., Patterson M. F., Hill C., Kelly A. L., Role for compatible solutes glycine betaine and L-carnitine in listerial barotolerance Applied and Environmental Microbiology 2004 70 12 7555 7557
17. Smiddy M., OGorman L., Sleator R. D., Greater high-pressure resistance of bacteria in oysters than in buffer Innovative Food Science and Emerging Technologies 2005 6 1 83 90
18. Corcoran B. M., Ross R. P., Fitzgerald G. F., Dockery P., Stanton C., Enhanced survival of GroESL-overproducing Lactobacillus paracasei NFBC 338 under stressful conditions induced by drying Applied and Environmental Microbiology 2006 72 7 5104 5107
19. Sleator R. D., Hill C., New frontiers in probiotic research Letters in Applied Microbiology 2008 46 2 143 147
20. Watson D., Sleator R. D., Hill C., Gahan C. G. M., Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract BMC Microbiology 2008 8 176
21. Termont S., Vandenbroucke K., Iserentant D., Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance Applied and Environmental Microbiology 2006 72 12 7694 7700
22. Denou E., Pridmore R. D., Berger B., Panoff J.-M., Arigoni F., Brssow H., Identification of genes associated with the long-gut-persistence phenotype of the probiotic Lactobacillus johnsonii strain NCC533 using a combination of genomics and transcriptome analysis Journal of Bacteriology 2008 190 9 3161 3168
23. Sleator R. D., Gahan C. G., Hill C., Mutations in the listerial proB gene leading to proline overproduction: effects on salt tolerance and murine infection Applied and Environmental Microbiology 2001 67 10 4560 4565
24. Paton A. W., Morona R., Paton J. C., A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans Nature Medicine 2000 6 3 265 270
25. Paton A. W., Morona R., Paton J. C., Neutralization of Shiga toxins Stx1, Stx2c, and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose Infection and Immunity 2001 69 3 1967 1970
26. Paton A. W., Jennings M. P., Morona R., Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea Gastroenterology 2005 128 5 1219 1228
27. Rao S., Hu S., McHugh L., Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide Proceedings of the National Academy of Sciences of the United States of America 2005 102 34 11993 11998
28. Chang T. L.-Y., Chang C.-H., Simpson D. A., Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4 Proceedings of the National Academy of Sciences of the United States of America 2003 100 20 11672 11677
29. Guimares V. D., Gabriel J. E., Lefvre F., Internalin-expressing Lactococcus lactis is able to invade small intestine of guinea pigs and deliver DNA into mammalian epithelial cells Microbes and Infection 2005 7 5-6 836 844
30. Holmgren J., Czerkinsky C., Mucosal immunity and vaccines Nature Medicine 2005 11 supplement 4 S45 S53
31. Sleator R. D., Hill C., Probiotics as therapeutics for the developing world Journal of Infection in Developing Countries 2007 1 7 12
32. Steidler L., Neirynck S., Huyghebaert N., Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10 Nature Biotechnology 2003 21 7 785 789
33. Sleator R. D., Hill C., Battle of the bugs Science 2008 321 5894 1294 1295
34. Sleator R. D., Hill C., Designer probiotics: a potential therapeutic for clostridium difficile? Journal of Medical Microbiology 2008 57 6 793 794