'Bioengineered Bugs' - A patho-biotechnology approach to probiotic research and applications

Medical Hypotheses

Volumn 70, Issue 1, 2008, Pages 167-169

  Sleator, Roy D ^a   Hill, Colin ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG VEHICLE; PROBIOTIC AGENT; VACCINE;

ARTICLE; BACTERIUM; BIOENGINEERING; BIOTECHNOLOGY; CLINICAL EFFECTIVENESS; DRUG DELIVERY SYSTEM; HOST RESISTANCE; IMMUNE SYSTEM; PATHOBIOTECHNOLOGY; PRIORITY JOURNAL; PROBIOTIC CULTURE; RESEARCH; STRESS; TREATMENT PLANNING;

ANIMALS; BACTERIA; BIOTECHNOLOGY; BLOOD-BORNE PATHOGENS; ENGINEERING; PROBIOTICS; VACCINES;

EID: 36348934989     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.03.008     Document Type: Article

References (16)

1. Fuller R. Probiotics in man and animals. J Appl Bacteriol 66 (1989) 365-378
2. Shanahan F. The host-microbe interface within the gut. Best Pract Res Clin Gastroenterol 16 (2005) 915-931
3. Backhed F., Ley R.E., Sonnenburg J.L., Peterson D.A., and Gordon J.I. Host-bacterial mutualism in the human intestine. Science 307 (2005) 1915-1920
4. Tlaskalova-Hogenova H., Stepankova R., Hudcovic T., et al. Commensal bacteria (normal microflora) mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol Lett 93 (2004) 97-108
5. Dunne C., Murphy L., Flynn S., et al. Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials. Antonie van Leeuwenhoek 76 (1999) 279-292
6. Shanahan F. Probiotics and the immune response: how much can we expect?. J Pediatr Gastroenterol Nutr 39 (2004) S748-S749
7. Sleator R.D., and Hill C. Patho-biotechnology; using bad bugs to do good things. Curr Opin Biotechnol 17 (2006) 211-216
8. Sleator R.D., and Hill C. Patho-biotechnology; using bad bugs to make good bugs better. Sci Prog 90 (2007) 1-14
9. Sheehan V.M., Sleator R.D., Fitzgerald G.F., and Hill C. Heterologous expression of BetL, a betaine uptake system, enhances the stress tolerance of Lactobacillus salivarius UCC118. Appl Environ Microbiol 72 (2006) 2170-2177
10. Sheehan VM, Sleator RD, Hill C, Fitzgerald GF. Improving gastric transit, gastrointestinal persistence and therapeutic efficacy of Bifidobacterium breve UCC2003 using a patho-biotechnology approach. Microbiology, in press.
11. Holmgren J., and Czerkinsky C. Mucosal immunity and vaccines. Nat Med 11 (2005) S45-S53
12. Roland K.L., Tinge S.A., Killeen K.P., and Kochi S.K. Recent advances in the development of live, attenuated bacterial vectors. Curr Opin Mol Ther 7 (2005) 62-72
13. Li Z., Zhao X., Higgins D.E., and Frankel F.R. Conditional lethality yields a new vaccine strain of Listeria monocytogenes for the induction of cell-mediated immunity. Infect Immun 73 (2005) 5065-5073
14. Guimarães V.D., Gabriel J.E., Lefèvre F., et al. Internalin-expressing Lactococcus lactis is able to invade small intestine of guinea pigs and deliver DNA into mammalian epithelial cells. Microbes Infect 7 (2005) 836-844
15. Sleator R.D., and Hill C. Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence. FEMS Microbiol Rev 26 (2002) 49-71
16. Foster J.W., and Spector M.P. How Salmonella survive against the odds. Annu Rev Microbiol 49 (1995) 145-174