Genetic complementation results in augmented autoantibody responses to lupus-associated antigens

Journal of Immunology

Volumn 183, Issue 5, 2009, Pages 3505-3511

  Sim, Davis L ^a   Bagavant, Harini ^a   Scindia, Yogesh M ^a   Ge, Yan ^a   Gaskin, Felicia ^a   Fu, Shu Man ^a   Deshmukh, Umesh S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; INTERFERON; INTERLEUKIN 6; TOLL LIKE RECEPTOR 7; ANTINUCLEAR ANTIBODY; DNA; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN; TLR7 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC COMPLEMENTATION; KIDNEY DISEASE; MALE; MOUSE; MOUSE STRAIN; NEW ZEALAND; NONHUMAN; NONOBESE DIABETIC MOUSE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; BIOSYNTHESIS; BLOOD; GENETICS; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; LUPUS ERYTHEMATOSUS NEPHRITIS; NEW ZEALAND BLACK MOUSE; PHYSIOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; DNA; FEMALE; GENETIC COMPLEMENTATION TEST; INTERFERON TYPE I; LUPUS NEPHRITIS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; MICE, INBRED NZB; RIBONUCLEOPROTEINS, SMALL NUCLEAR; TOLL-LIKE RECEPTOR 7;

EID: 70349229408     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901207     Document Type: Article

References (27)

1. Tan, E. M., A. S. Cohen, J. F. Fries, A. T. Masi, D. J. McShane, N. F. Rothfield, J. G. Schaller, N. Talal, and R. J. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25: 1271-1277.
2. Barada, F. A., Jr., B. S. Andrews, J. S. Davis IV, and R. P. Taylor. 1981. Antibodies to Sm in patients with systemic lupus erythematosus: correlation of Sm antibody titers with disease activity and other laboratory parameters. Arthritis Rheum. 24: 1236-1244.
3. Benito-Garcia, E., P. H. Schur, R. Lahita, and American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines. 2004. Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-Sm and anti-RNP antibody tests. Arthritis Rheum. 51: 1030-1044.
4. Font, J., R. Cervera, M. Ramos-Casals, M. Garcia-Carrasco, J. Sents, C. Herrero, J. A. del Olmo, A. Darnell, and M. Ingelmo. 2004. Clusters of clinical and immunologic features in systemic lupus erythematosus: analysis of 600 patients from a single center. Semin. Arthritis Rheum. 33: 217-230.
5. Pisitkun, P., J. A. Deane, M. J. Difilippantonio, T. Tarasenko, A. B. Satterthwaite, and S. Bolland. 2006. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312: 1669-1672.
6. Christensen, S. R., J. Shupe, K. Nickerson, M. Kashgarian, R. A. Flavell, and M. J. Shlomchik. 2006. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25: 417-428.
7. Deane, J. A., P. Pisitkun, R. S. Barrett, L. Feigenbaum, T. Town, J. M. Ward, R. A. Flavell, and S. Bolland. 2007. Control of Toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 27: 801-810.
8. Lee, P. Y., Y. Kumagai, Y. Li, O. Takeuchi, H. Yoshida, J. Weinstein, E. S. Kellner, D. Nacionales, T. Barker, K. Kelly-Scumpia, et al. 2008. TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus. J. Exp. Med. 205: 2995-3006.
9. Vollmer, J., S. Tluk, C. Schmitz, S. Hamm, M. Jurk, A. Forsbach, S. Akira, K. M. Kelly, W. H. Reeves, S. Bauer, and A. M. Krieg. 2005. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202: 1575-1585.
10. Lau, C. M., C. Broughton, A. S. Tabor, S. Akira, R. A. Flavell, M. J. Mamula, S. R. Christensen, M. J. Shlomchik, G. A. Viglianti, I. R. Rifkin, and A. Marshak-Rothstein. 2005. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202: 1171-1177.
11. Kirou, K. A., C. Lee, S. George, K. Louca, M. G. Peterson, and M. K. Crow. 2005. Activation of the interferon-α pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. Arthritis Rheum. 52: 1491-1503.
12. Niewold, T. B., J. Hua, T. J. Lehman, J. B. Harley, and M. K. Crow. 2007. High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun. 8: 492-502. (Pubitemid 47365615)
13. Waters, S. T., S. M. Fu, F. Gaskin, U. S. Deshmukh, S. S. Sung, C. C. Kannapell, K. S. Tung, S. B. McEwen, and M. McDuffie. 2001. NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci. Clin. Immunol. 100: 372-383.
14. Waters, S. T., M. McDuffie, H. Bagavant, U. S. Deshmukh, F. Gaskin, C. Jiang, K. S. Tung, and S. M. Fu. 2004. Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J. Exp. Med. 199: 255-264.
15. Hawke, C. G., D. M. Painter, P. D. Kirwan, R. R. Van Driel, and A. G. Baxter. 2003. Mycobacteria, an environmental enhancer of lupus nephritis in a mouse model of systemic lupus erythematosus. Immunology 108: 70-78.
16. Koarada, S., Y. Wu, N. Fertig, D. A. Sass, M. Nalesnik, J. A. Todd, P. A. Lyons, J. Fenyk-Melody, D. B. Rainbow, L. S. Wicker, L. B. Peterson, and W. M. Ridgway. 2004. Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain. J. Immunol. 173: 2315-2323.
17. Irie, J., Y. Wu, D. A. Sass, and W. M. Ridgway. 2006. Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region. Immunogenetics 58: 9-14.
18. Deshmukh, U. S., H. Bagavant, D. Sim, V. Pidiyar, and S. M. Fu. 2007. A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading. J. Immunol. 178: 2565-2571.
19. + T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis. J. Immunol. 175: 944-950.
20. T) method. Methods 25: 402-408.
21. Bagavant, H., U. S. Deshmukh, H. Wang, T. Ly, and S. M. Fu. 2006. Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes. J. Immunol. 177: 8258-8265.
22. Hua, J., K. Kirou, C. Lee, and M. K. Crow. 2006. Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies. Arthritis Rheum. 54: 1906-1916.
23. Nacionales, D. C., K. M. Kelly-Scumpia, P. Y. Lee, J. S. Weinstein, R. Lyons, E. Sobel, M. Satoh, and W. H. Reeves. 2007. Deficiency of the type I interferon receptor protects mice from experimental lupus. Arthritis Rheum. 56: 3770-3783.
24. Chaturvedi, A., D. Dorward, and S. K. Pierce. 2008. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 28: 799-809.
25. Watanabe, K., and T. Tsubata. 2009. Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes. Autophagy 5: 108-110.
26. 1 mice: a new model of lupus-like disease. J. Exp. Med. 179: 1429-1435.
27. Kelley, J., M. R. Johnson, G. S. Alarcon, R. P. Kimberly, and J. C. Edberg. 2007. Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects. Arthritis Rheum. 56: 3375-3378.