A comparison before and after aprotinin was suspended in cardiac surgery: Different results in the real world from a single cardiac center in China

Journal of Thoracic and Cardiovascular Surgery

Volumn 138, Issue 4, 2009, Pages 897-903

  Wang, Xianqiang ^a   Zheng, Zhe ^a   Ao, Hushan ^b   Zhang, Shiju ^a   Wang, Yang ^a   Zhang, Hao ^a   Li, Lihuan ^b   Hu, Shengshou ^a  

^a Research Center for Cardiovascular Regenerative Medicine   (China)

^b FUWAI HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ;

ADULT; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTICLE; ARTIFICIAL VENTILATION; BLOOD TRANSFUSION; CHINA; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART DISEASE; HEART SURGERY; HUMAN; KIDNEY DISEASE; LOADING DRUG DOSE; LUNG COMPLICATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUROLOGICAL COMPLICATION; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; REOPERATION; RISK ASSESSMENT;

AGED; APROTININ; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; CARDIAC SURGICAL PROCEDURES; FEMALE; HEMOSTATICS; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; REOPERATION; RESPIRATION, ARTIFICIAL; SERINE PROTEINASE INHIBITORS;

EID: 70349227137     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2009.03.021     Document Type: Article

References (26)

1. Royston D., Bidstrup B.P., Taylor K.M., and Sapsford R.N. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 2 (1987) 1289-1291
2. Havel M., Grabenwöger F., and Schneider J. Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood. J Thorac Cardiovasc Surg 107 (1994) 807-810
3. Hayashida N., Isomura T., Sato T., Maruyama H., Kosuga K., and Aoyagi S. Effects of minimal-dose aprotinin on coronary artery bypass grafting. J Thorac Cardiovasc Surg 114 (1997) 261-269
4. Murkin J.M. Attenuation of neurologic injury during cardiac surgery. Ann Thorac Surg 72 (2001) S1838-S1844
5. Sedrakyan A., Treasure T., and Elefteriades J.A. Efect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials. J Thorac Cardiovasc Surg 128 (2004) 442-448
6. Poston R.S., White C., and Gu J. Aprotinin shows both hemostatic and antithrombotic effects during off-pump coronary artery bypass grafting. Ann Thorac Surg 81 (2006) 104-110
7. Royston D., Levy J.H., and Fitch J. Full-dose aprotinin use in coronary artery bypass graft surgery: an analysis of perioperative pharmacotherapy and patient outcomes. Anesth Analg 103 (2006) 1082-1088
8. Ronald A., and Dunning J. Does use of aprotinin decrease the incidence of stroke and neurological complications in adult patients undergoing cardiac surgery?. Interact Cardiovasc Thorac Surg 5 (2006) 767-773
9. Mangano D.T., Tudor I.C., and Dietzel C. Multicenter Study of Perioperative Ischemia Research Group; Ischemia Research and Education Foundation. The risk associated with aprotinin in cardiac surgery. N Engl J Med 354 (2006) 353-365
10. Mangano D.T., Miao Y., Vuylsteke A., Tudor I.C., Juneja R., Filipescu D., et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 297 (2007) 471-479
11. Kertai M.D., Varga K.S., Royston D., London M.J., Szabolcs Z., Grebenik C.R., et al. Aprotinin and perioperative complications in cardiac surgery. J Cardiovasc Surg (Torino) 48 (2007) 761-772
12. Mouton R., Finch D., Davies I., Binks A., and Zacharowski K. Effect of aprotinin on renal dysfunction in patients undergoing on-pump and off-pump cardiac surgery: a retrospective observational study. Lancet 371 (2008) 475-482
13. Koster A., Buz S., Krabatsch T., Dehmel F., Kuppe H., Hetzer R., et al. High-dose aprotinin effectively reduces blood loss during on-pump coronary artery bypass grafting with bivalirudin anticoagulation. J Thorac Cardiovasc Surg 135 (2008) 685-687
14. Pagano D., Howell N.J., Freemantle N., Cunningham D., Bonser R.S., Graham T.R., et al. Bleeding in cardiac surgery: the use of aprotinin does not affect survival. J Thorac Cardiovasc Surg 135 (2008) 495-502
15. Schneeweiss S., Seeger J.D., Landon J., and Walker A.M. Aprotinin during coronary-artery bypass grafting and risk of death. N Engl J Med 358 (2008) 771-783
16. Shaw A.D., Stafford-Smith M., White W.D., Phllips-Bute B., Swaminathan M., Milano C., et al. The effect of aprotinin on outcome after coronary-artery bypass grafting. N Engl J Med 358 (2008) 784-793
17. Fergusson D.A., Hébert P.C., Mazer C.D., Fremes S., MacAdams C., Murkin J.M., et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 358 (2008) 2319-2331
18. Kain K., Catto A.J., and Grant P.J. Impaired fibrinolysis and increased fibrinogen levels in South Asian subjects. Atherosclerosis 156 (2001) 457-461
19. Forouhi N.G., Rumley A., and Lowe G.D. Specific elevation in plasma tissue plasminogen activator antigen concentrations in South Asians relative to Europeans. Blood Coagul Fibrinolysis 14 (2003) 755-760
20. El Rouby S., Mestres C.A., LaDuca F.M., and Zucker M.L. Racial and ethnic differences in warfarin response. J Heart Valve Dis 13 (2004) 15-21
21. Yu H.Y., Liu C.H., Chen Y.S., Wang S.S., Chu S.H., and Lin F.Y. Relationship of international normalized ratio to bleeding and thromboembolism rates in Taiwanese patients receiving vitamin K antagonist after mechanical valve replacement. J Formos Med Assoc 104 (2005) 236-243
22. McEvoy M.D., Reeves S.T., Reves J.G., and Spinale F.G. Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action. Anesth Analg 105 (2007) 949-962
23. Khan T.A., Bianchi C., and Voisine P. Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest. J Thorac Cardiovasc Surg 128 (2004) 602-608
24. Lazar H.L., Bao Y., Tanzillo L., O'Gara P., Reardon D., Price D., et al. Aprotinin decreases ischemic damage during coronary revascularization. J Card Surg 20 (2005) 519-523
25. Kunt A.S., Darcin O.T., Aydin S., Demir D., Selli C., and Andac M.H. Mini-dose pump-prime aprotinin inhibited enhanced fibrinolytic activity and reduced blood loss and transfusion requirements after coronary artery bypass surgery. J Thromb Thrombolysis 19 (2005) 197-200
26. Erdogan M., Kalaycioglu S., and Iriz E. Protective effect of aprotinin against lung damage in patients undergoing CABG surgery. Acta Cardiol 60 (2005) 367-372