High-dose aprotinin effectively reduces blood loss during on-pump coronary artery bypass grafting with bivalirudin anticoagulation

Journal of Thoracic and Cardiovascular Surgery

Volumn 135, Issue 3, 2008, Pages 685-687

  Koster, Andreas ^a   Buz, Semih ^a   Krabatsch, Thomas ^a   Dehmel, Frank ^a   Kuppe, Hermann ^a   Hetzer, Roland ^a   Aronson, Solomon ^b   Dyke, Cornelius M ^c  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c Gaston Memorial Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; HIRULOG;

ADULT; AGED; ANTICOAGULATION; ARTICLE; BLOOD TRANSFUSION; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; FEMALE; HUMAN; MALE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL;

AGED; ANTICOAGULANTS; APROTININ; BLOOD LOSS, SURGICAL; CORONARY ARTERY BYPASS; CORONARY DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HIRUDINS; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROBABILITY; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; REFERENCE VALUES; RISK ASSESSMENT; SINGLE-BLIND METHOD; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 40149090649     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2007.09.018     Document Type: Article

References (5)

1. Koster A., Dyke C.M., Aldea G., et al. Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial. Ann Thorac Surg 83 (2007) 572-577
2. Koster A., Yeter R., Buz S., et al. Assessment of hemostatic activation during cardiopulmonary bypass for coronary artery bypass grafting with bivalirudin: results of a pilot study. J Thorac Cardiovasc Surg 129 (2005) 1391-1394
3. Koster A., Spiess B.D., Chew D.P., et al. Effectiveness of bivalirudin as a replacement for heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting. Am J Cardiol 93 (2004) 356-359
4. Mangano D.T., Tudor I.C., Dietzel C., and Multicenter Study of Perioperative Research Group. Ischemia Research and Education Foundation. The risk associated with aprotinin in cardiac surgery. N Engl J Med 354 (2006) 353-365
5. Mangano D.T., Miao Y., Vuylsteke A., et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 297 (2007) 471-479