Influence of different ways of euthanasia on the activity of cholinesterases in the rat

Journal of Applied Biomedicine

Volumn 7, Issue 3, 2009, Pages 133-136

  Novotný, Ladislav ^a,b   Misík, Jan ^c   Karasová, Jana ^c   Kuča, Kamil ^a,c   Bajgar, Jiří ^c  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Anesthesia; Animal welfare; Carbon dioxide; Ellman's method; Ether; Nembutal; Pentobarbital

Indexed keywords

ACETYLCHOLINESTERASE; CARBON DIOXIDE; CHOLINESTERASE; PENTOBARBITAL;

ANESTHESIA; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECAPITATION; ENZYME ACTIVITY; EUTHANASIA; EXSANGUINATION; FEMALE; IMMERSION; INTERMETHOD COMPARISON; NONHUMAN; PERICARDIOCENTESIS; RAT;

ANIMALIA; RATTUS;

EID: 70349226363     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.32725/jab.2009.014     Document Type: Article

References (13)

1. Bajgar J, Fusek J, Kuča K, Bartošová L, Jun D: Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction. Mini Rev Med Chem 7:461-466, 2007.
2. Barbaccia ML, Roscetti G, Trabucchi M, Mostallino MC, Concas A, Purdy RH, Biggio G: Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress. Neuroendocrinology 63:166-172, 1996.
3. Blackshaw JK, Fenwick DC, Beattie AW, Allan DJ: The behaviour of chickens, mice and rats during euthanasia with chloroform, carbon dioxide and ether. Lab Anim 22:67-75, 1988.
4. Breazile JE, Kitchell RL: Euthanasia for laboratory animals. Fed Proc 28:1577-1579, 1969.
5. Close B, Banister K, Baumans V, Bernoth EM, Bromage N, Bunyan J, Erhardt W, Flecknell P, Gregory N, Hackbarth H, Morton D, Warwick C: Recommendations for euthanasia of experimental animals: Part 1. DGXI of the European Commission. Lab Anim 30:293-316, 1996.
6. Conlee KM, Stephens ML, Rowan AN, King LA: Carbon dioxide for euthanasia: concerns regarding pain and distress, with special reference to mice and rats. Lab Anim 39:137-161, 2005.
7. Ellman GL, Courtney DK, Andres V, Featherstone RM: A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95, 1961.
8. Fenwick D: Rats and Mice. In Reilly J (ed.): Euthanasia of Animals Used for Scientific Purposes. ANZCCART, Glen Osmond, South Australia 2001, pp. 25-33.
9. Green AR, Metz A, Minchin MC, Vincent ND: Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion. Br J Pharmacol 92:5-11, 1987.
10. Hackbarth H, Küppers N, Bohnet W: Euthanasia of rats with carbon dioxide-animal welfare aspects. Lab Anim 34:91-96, 2000.
11. Kuča K, Jun D, Bajgar J: Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications. Curr Pharm Des 33:3445-3452, 2007.
12. Musílek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuča K: Design of a potent reactivator of tabun-inhibited acetylcholinesterase-synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but- 2-ene dibromide (K203). J Med Chem 50:5514-5518, 2007.
13. 2 in rats: is it a peripheral nociceptive event? Neurosci Lett 128:297-300, 1991.