The contribution of acetaldehyde from alcohol to cancer: A review and exposure estimate for Germany

Sucht

Volumn 55, Issue 2, 2009, Pages 111-117

  Kanteres, Fotis ^a   Lachenmeier, Dirk W ^b   Rehm, Jürgen ^a,c,d  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe   (Germany)

^c UNIVERSITY OF TORONTO   (Canada)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Acetaldehyde; Alcohol; Cancer; Esophagus; Metabolism; Risk assessment

Indexed keywords

ACETALDEHYDE; ALCOHOL; CARCINOGEN;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ARTICLE; BREAST CANCER; CANCER RISK; CARCINOGENICITY; CIGARETTE SMOKING; COLON CANCER; ENVIRONMENTAL EXPOSURE; ESOPHAGUS CANCER; EVIDENCE BASED PRACTICE; GENOTOXICITY; GERMANY; HIGH RISK BEHAVIOR; HUMAN; INGESTION; LARYNX CANCER; LIVER CANCER; MOUTH CANCER; NEOPLASM; NONHUMAN; PHARYNX CANCER; PUBLIC HEALTH; RATING SCALE; RECTUM CANCER; RISK ASSESSMENT; RISK FACTOR; STOMACH CANCER; WORLD HEALTH ORGANIZATION;

EID: 70349213625     PISSN: 09395911     EISSN: None     Source Type: Journal    
DOI: 10.1024/2009.02.07     Document Type: Article

References (47)

1. Baan, R., Straif, K., Grosse, Y., Secretan, B., El Ghissassi, F., Bouvard, V. et al. (2007). Carcinogenicity of alcoholic beverages. Lancet Oncology, 8, 292-293.
2. Babor, T., Caetano, R., Casswell, S., Edwards, G., Giesbrecht, N., Graham, K. et al. (2005). Alkohol: kein gewöhnliches Konsumgut. Forschung und Alkoholpolitik. Göttingen, Hogrefe.
3. Boffetta, P. & Hashibe, M. (2006). Alcohol and cancer. Lancet Oncology, 7, 149-156.
4. Boffetta, P., Hashibe, M., La Vecchia, C., Zatonski, W. & Rehm, J. (2006). The burden of cancer attributable to alcohol drinking. International Journal of Cancer, 119, 884-887.
5. Brooks, P.J., Enoch, M.A., Goldman, D., Li, T.K. & Yokoyama, A. (2009). The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Medicine, 6, 258-263.
6. Coutelle, C., Höhn, B., Benesova, M., Oneta, C.M., Quattrochi, P., Roth, H.J. et al. (2004). Risk factors in alcohol associated breast cancer. International Journal of Oncology, 25, 1127-1132.
7. Ebeler, S.E. & Spaulding, R.S. (1998). Characterization and measurement of aldehydes in wine. In A.L. Waterhouse & S.E. Ebeler (Eds.), Chemistry of wine flavor (pp. 166-179). Washington, DC: American Chemical Society.
8. Egerer, G., Stickel, F., & Seitz, H.K. (2005). Alcohol and the gastrointestinal tract. In V.R. Preedy & R.R. Watson (Eds.), Comprehensive handbook of alcohol related pathology. (pp. 557-570). London: Elsevier Academic Press.
9. Eriksson, C.J. (2007). Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? Novartis Foundation Symposium, 285, 247-255.
10. Eriksson, C.J. & Fukunaga, T. (1993). Human blood acetaldehyde (update 1992). Alcohol and Alcoholism, Suppl. 2, 9-25.
11. European Food Safety Authority (2005). Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA Journal, 282, 1-31.
12. Ezzati, M., Lopez, A., Rodgers, A. & Murray, C. (2004). Comparative quantification of health risks. Global and regional burden of disease attributable to selected major risk factors. Geneva, Switzerland: WHO.
13. Feron, V.J., Til, H.P., de Vrijer, F., Woutersen, R.A., Cassee, F.R. & van Bladeren, P.J. (1991). Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment. Mutation Research, 259, 363-385.
14. Hall, R.L. & Oser, B.L. (1965). Recent progress in the consideration of flavoring ingredients under the food additives amendment. III. GRAS substances. Food Technology, 19, 197.
15. Homann, N., König, I.R., Marks, M., Benesova, M., Stickel, F., Millonig, G. et al. (2009). Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1C polymorphism. Alcoholism: Clinical and Experimental Research, 33, 551-556.
16. Homann, N., Stickel, F., König, I.R., Jacobs, A., Junghanns, K., Benesova, M. et al. (2006). Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. International Journal of Cancer, 118, 1998-2002.
17. Homann, N., Tillonen, J., Meurman, J.H., Rintamäki, H., Lindqvist, C., Rautio, M. et al. (2000). Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer. Carcinogenesis, 21, 663-668.
18. IARC (1987). IARC Monographs on the evaluation of carcinogenic risks to humans, supplement 7. Overall evaluations of carcinogenicity: an updating of IARC monographs vols 1-42. Lyon, France: IARC.
19. IARC. (1988). IARC Monographs on the evaluation of carcinogenic risks to humans. Alcohol Drinking. Vol. 44. Alcohol Drinking. Lyon, France: IARC.
20. IARC (1999). IARC Monographs on the evaluation of carcinogenic risks to humans, vol. 71. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. Lyon, France: IARC.
21. IARC (2008). World cancer report 2008. Lyon, France: IARC.
22. Joint FAO/WHO Expert Committee on Food Additives (1998). Saturated aliphatic acyclic linear primary alcohols, aldehydes, and acids. In WHO (Ed). Food additives series 40. Safety evaluation of certain food additives and contaminants. (pp. 148-188). Geneva, Switzerland: WHO.
23. Lachenmeier, D.W., Kanteres, F. & Rehm, J. (2009). Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. Addiction, 104, 533-550.
24. Lachenmeier, D.W. & Sohnius, E.M. (2008). The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: evidence from a large chemical survey. Food and Chemical Toxicology, 46, 2903-2911.
25. Linderborg, K., Joly, J.P., Visapää, J.P. & Salaspuro, M. (2008). Potential mechanism for Calvados-related oesophageal cancer. Food and Chemical Toxicology, 46, 476-479. (Pubitemid 350297527)
26. Liu, S.Q. & Pilone, G.J. (2000). An overview of formation and roles of acetaldehyde in winemaking with emphasis on microbiological implications. International Journal of Food Science, 35, 49-61.
27. Paton, A. (2005). Alcohol in the body. British Medical Journal, 330, 85-87.
28. Pöschl, G. & Seitz, H.K. (2004). Alcohol and cancer. Alcohol and Alcoholism, 39, 155-165.
29. Rehm, J. & Greenfield, T.K. (2008). Public alcohol policy: current directions and new opportunities. Clinical Pharmacology and Therapeutics, 83, 640-643.
30. Rehm, J., Klotsche, J. & Patra, J. (2007). Comparative quantification of alcohol exposure as risk factor for global burden of disease. International Journal of Methods in Psychiatric Research, 16, 66-76.
31. Rehm, J., Patra, J., Baliunas, D., Popova, S., Roerecke, M., & Taylor, B. (2008). Alcohol, the burden of disease of. In K. Heggenhougen & S. Quah (Eds.), International Encyclopedia of Public Health (pp. 135-151). San Diego, CA: Academic Press.
32. Rehm, J., Rehn, N., Room, R., Monteiro, M., Gmel, G., Jernigan, D. et al. (2003). The global distribution of average volume of alcohol consumption and patterns of drinking. European Addiction Research, 9, 147-156. (Pubitemid 37140369)
33. Rehm, J., Room, R., Graham, K., Monteiro, M., Gmel, G., & Sempos, C. (2003). The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease - An overview. Addiction, 98, 1209-1228. (Pubitemid 37082815)
34. Rehm, J., Room, R., Monteiro, M., Gmel, G., Graham, K., Rehn, N. et al. (2003). Alcohol as a risk factor for global burden of disease. European Addiction Research, 9, 157-164.
35. Rehm, J., Room, R., Monteiro, M., Gmel, G., Graham, K., Rehn, N. et al. (2004). Alcohol Use. In M. Ezzati, A.D. Lopez, A. Rodgers, & C.J.L. Murray (Eds.), Comparative quantification of health risks. Global and regional burden of disease attributable to selected major risk factors. Volume 1 (pp. 959-1109). Geneva, Switzerland: WHO.
36. Salaspuro, M.(2009).Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. Scandinavian Journal of Gastroenterology, (in press).
37. Salaspuro, M. (2009). Acetaldehyde: a cumulative carcinogen in humans. Addiction, 104, 551-553.
38. Sanner, T., Dybing, E., Willems, M. I. & Kroese, E. D (2001). A simple method for quantitative risk assessment of non-threshold carcinogens based on the dose descriptor T25. Pharmacology & Toxicology, 88, 331-41. (Pubitemid 32595841)
39. Seitz, H.K. & Becker, P. (2007). Alcohol metabolism and cancer risk. Alcohol Research & Health, 30, 38-47.
40. Seitz, H.K. & Stickel, F. (2007). Molecular mechanisms of alcohol-mediated carcinogenesis. Nature Reviews. Cancer., 7, 599-612.
41. Väkeväinen, S., Mentula, S., Nuutinen, H., Salmela, K.S., Jousimies-Somer, H., Färkkilä, M. et al. (2002). Ethanol-derived microbial production of carcinogenic acetaldehyde in achlorhydric atrophic gastritis. Scandinavian Journal of Gastroenterology, 37, 648-655.
42. Väkeväinen, S., Tillonen, J., Agarwal, D.P., Srivastava, N. & Salaspuro, M. (2000). High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: strong evidence for the local carcinogenic action of acetaldehyde. Alcoholism: Clinical and Experimental Research, 24, 873-877.
43. Väkeväinen, S., Tillonen, J., & Salaspuro, M. (2001). 4-Methylpyrazole decreases salivary acetaldehyde levels in ALDH2-deficient subjects but not in subjects with normal ALDH2. Alcoholism: Clinical and Experimental Research, 25, 829-834. (Pubitemid 32552488)
44. Visapää, J.P., Götte, K., Benesova, M., Li, J., Homann, N., Conradt, C. et al. (2004). Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde. Gut, 53, 871-876.
45. Xue, F.B., Xu, Y.Y., Wan, B.R., Pan, B.R., Ren, J. & Fan, D.M. (2003). Association of H. pylori Infection with gastric carcinoma: a meta-analysis. World Journal of Gastroenterology, 7, 801-804.
46. Yokoyama, A., Muramatsu, T., Ohmori, T., Yokoyama, T., Matsushita, S., Higuchi, S. et al. (2001). Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis, 22, 433-439.
47. Yokoyama, A., Tsutsumi, E., Imazeki, H., Suwa, Y., Nakamura, C., Mizukami, T. et al. (2008). Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. Alcoholism: Clinical and Experimental Research, 32, 1607-1614.