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Volumn 50, Issue 5, 2009, Pages 897-904
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Determination of dexmedetomidine in human plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: Application to a pharmacokinetic study
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Author keywords
Dexmedetomidine; HPLC MS MS; Human plasma; Pharmacokinetics
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Indexed keywords
ACETONITRILE;
DEXMEDETOMIDINE;
ETHER;
FORMIC ACID;
ONDANSETRON;
ACCURACY;
AREA UNDER THE CURVE;
ARTICLE;
CHINESE;
CLINICAL TRIAL;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
DOSE RESPONSE;
DRUG CLEARANCE;
DRUG DETERMINATION;
DRUG DISTRIBUTION;
DRUG DOSE COMPARISON;
DRUG HALF LIFE;
DRUG ISOLATION;
DRUG MEGADOSE;
ELECTROSPRAY MASS SPECTROMETRY;
FEMALE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HUMAN EXPERIMENT;
LOW DRUG DOSE;
MALE;
MAXIMUM PLASMA CONCENTRATION;
MEAN RESIDENCE TIME;
NORMAL HUMAN;
OPEN STUDY;
PRIORITY JOURNAL;
PROCESS DEVELOPMENT;
QUANTITATIVE ANALYSIS;
RANDOMIZED CONTROLLED TRIAL;
SENSITIVITY AND SPECIFICITY;
SEX DIFFERENCE;
TANDEM MASS SPECTROMETRY;
TIME TO MAXIMUM PLASMA CONCENTRATION;
VALIDATION PROCESS;
VOLUNTEER;
ACETONITRILES;
CHEMISTRY, PHARMACEUTICAL;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DEXMEDETOMIDINE;
DRUG STABILITY;
FEMALE;
FORMIC ACIDS;
HUMANS;
IONS;
MALE;
MODELS, CHEMICAL;
ONDANSETRON;
REFERENCE STANDARDS;
REPRODUCIBILITY OF RESULTS;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
TANDEM MASS SPECTROMETRY;
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EID: 70349186586
PISSN: 07317085
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jpba.2009.06.012 Document Type: Article |
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Times cited : (32)
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References (4)
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