Simultaneous determination of senecionine, adonifoline and their metabolites in rat serum by UPLC-ESIMS and its application in pharmacokinetic studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 5, 2009, Pages 1070-1074

  Xiong, Aizhen ^a,b   Li, Yan ^c   Yang, Li ^a,b   Gao, Jiangguo ^a,c   He, Yuqi ^a,b   Wang, Changhong ^a,b   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

^c XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Adonifoline; Hepatotoxic pyrrolizidine alkaloids; Pharmacokinetics; Senecionine; Solid phase extraction; UPLC ESIMS

Indexed keywords

ADONIFOLINE; ADONIFOLINE N OXIDE; PYRROLIZIDINE ALKALOID; SENECIONINE; SENECIONINE N OXIDE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CALIBRATION; CHEMISTRY TECHNIQUES, ANALYTICAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LACTONES; LIVER; MALE; MODELS, CHEMICAL; PYRROLIZIDINE ALKALOIDS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 70349182001     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.06.037     Document Type: Article

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