Synthesis and evaluation of pyrrolin-2-one compounds, a series of plasminogen activator inhibitor-1 inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 57, Issue 9, 2009, Pages 979-985

  Miyazaki, Hiroshi ^a   Ogiku, Tsuyoshi ^a   Sai, Hiroshi ^a   Moritani, Yasunori ^a   Ohtani, Akio ^a   Ohmizu, Hiroshi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Antithrombotic drug; Furan 2 one; Inhibitor; Plasminogen activator inhibitor 1; Pyrrolin 2 one

Indexed keywords

[3 (5 OXO 3,4 DIPHENYL 1,5 DIHYDROPYRROLYLIDENEMETHYL)PHENOXY]ACETIC ACID SODIUM; FURAN 2 ONE DERIVATIVE; FURANONE DERIVATIVE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PYRROLIN 2 ONE DERIVATIVE; PYRROLINE DERIVATIVE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; THROMBOSIS;

ANIMALS; FIBRINOLYTIC AGENTS; HUMANS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PYRROLES; PYRROLIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70349165391     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.57.979     Document Type: Article

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