Treatment of acquired severe aplastic anemia: Bone marrow transplantation compared with immunosuppressive therapy - The European Group for blood and marrow transplantation experience

Seminars in Hematology

Volumn 37, Issue 1, 2000, Pages 69-80

  Bacigalupo, Andrea ^a,b   Brand, Ronald ^a,b   Oneto, Rosi ^a,b   Bruno, Barbara ^a,b   Socié, Gerard ^a,b   Passweg, Jakob ^a,b   Locasciulli, Anna ^a,b   Van Lint, Maria Teresa ^a,b   Tichelli, André ^a,b   McCann, Shaun ^a,b   Marsh, Judith ^a,b   Ljungman, Per ^a,b   Hows, Jill ^a,b   Marin, Pedro ^a,b   Schrezenmeier, Hubert ^a,b  

^a Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; METHOTREXATE;

ADOLESCENT; ADULT; APLASTIC ANEMIA; ARTICLE; BONE MARROW TRANSPLANTATION; CHILD; DISEASE SEVERITY; GRAFT FAILURE; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; RELAPSE; TREATMENT OUTCOME;

EID: 12944332070     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0037-1963(00)90031-3     Document Type: Article

References (46)

1. Ascensao J, Kagan W, Moore M, et al: Aplastic anemia: Evidence for an immunological mechanism. Lancet 1:669-671, 1976
2. Bacigalupo A, Hows J, Gluckman E, et al: Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): A report of the EBMT SAA Working Party. Br J Haematol 177:70-74, 1988
3. Bacigalupo A, Chaple M, Hows J, et al: Treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG) and methylprednisolone (MPred) with or without androgens: A randomized trial from the EBMT SAA working party. Br J Haematol 83:145-151, 1993
4. Bacigalupo A, Broccia G, Corda G, et al: Antilymphocyte globulin, cyclosporin and granulocyte stimulating factor in patients with acquired severe aplastic anemia (SAA): A pilot study of the EBMT SAA working party. Blood 85:1348-1353, 1995
5. Bayever E, Champlin R, Ho W, et al: Comparison between bone marrow transplantation and antithymocyte globulin in treatment of young patients with severe aplastic anemia. J Pediatr 105:920-925, 1984
6. Brodsky RA, Sensenbrenner LL, Jones RJ: Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation. Blood 87:491-494, 1998
7. Camitta BM, Thomas ED, Nathan DG, et al: A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia. Blood 53:504, 1979
8. Camitta B, O'Reilly RJ, Sensenbrenner L, et al: Antithoracic duct lymphocyte globulin therapy of severe aplastic anemia. Blood 62:883-888, 1983
9. Champlin R, Ho W, Gale RP: Antithymocyte globulin treatment in patients with aplastic anemia: A prospective randomized trial. N Engl J Med 308:113-118, 1983
10. Champlin RE, HO WG, Nimer SD, et al: Bone Marrow transplantation for severe aplastic anemia. Transplantation 49:720-724, 1990
11. Deeg HJ, Leisenring W, Storb R, et al: Long term outcome after marrow transplantation for severe aplastic anemia. Blood 91:3637-3645, 1998
12. Doney K, Martin P, Storb R, et al: A randomized trial of antihuman thymocyte globulin versus murine monoclonal antihuman T-cell antibodies as immunosuppressive therapy for aplastic anemia. Exp Hematol 13:520-524, 1985
13. Doney K, Kopecky K, Storb R, et al: Long-term comparison of immunosuppressive therapy with antithymocyte globulin to bone marrow transplantation in aplastic anemia, in Shahidi NT (ed): Aplastic Anemia and Other Bone Marrow Failure Syndromes. 1990, p 104-114
14. Doney K, Leisenring W, Storb R, et al: Primary treatment of acquired aplastic anemia: Outcomes with bone marrow transplantation and immunosuppressive therapy. Ann Intern Med 126:107-115, 1997
15. Faille A, Barrett AJ, Balitrand N, et al: Effect of antilymphocyte globulin on granulocyte precursors in aplastic anemia. Br J Haematol 42:371-380, 1979
16. Frickhofen N, Kaltwasser JP, Schrezenmeier H, et al: Treatment of aplastic anemia with antithymocyte globulin and methylprednisolone with or without cyclosporine. N Engl J Med 324:1297-1304, 1991
17. Fuhrer M, Rampf U, Burdach S, et al: Immunosuppressive therapy (IST) and bone marrow transplantation (BMT) for aplastic anemia (AA) in children. Blood 92:156a, 1998 (suppl 1, abstr 631)
18. Gluckman E, Devergie A, Poros A, Degoulet P: Results of immunosuppression in 170 cases of severe aplastic anaemia. Report of the European Group of Bone Marrow Transplant (EGBMT). Br J Haematol 51:541-50, 1982
19. Gluckman E, Sociè G, Devergie A, et al: Bone marrow transplantation in 107 patients with severe aplastic anemia using cyclophosphamide and thoraco-abdominal irradiation for conditioning: long-term follow-up. Blood78:2451-2455, 1991
20. Goldberg MA, Antin JH, Guinan EC, et al: Cyclophosphamide cardiotoxicity: An analysis of dosing as a risk factor. Blood 68:1114-1148, 1986
21. Haak HL, Speck B: Inhibition of CFUE and BFUE by mononuclear peripheral blood cells during chronic benzene treatment in rabbits. Acta Haematol 67:27-33, 1982
22. Halperlin DS, Grisaru D, Freedman MH, et al: Severe acquired aplastic anemia in children: 11-year experience with bone marrow transplantation and immunosuppressive therapy. Am J Pediatr Hematol Oncol 11:304-309, 1989
23. Locasciulli A, Bacigalupo A, Van Lint MT, et al: Hepatitis B virus (HBV) infection and liver disease after allogeneic bone marrow transplantation: A report of 30 cases. Bone Marrow Transplant 6:25-29, 1990
24. Marsh JCW, Hows J, Bryett KA, et al: Survival after antilymphocyte globulin therapy for aplastic anemia depends on disease severity. Blood 70:1046-1052, 1987
25. Marsh J, Schrezenmeier H, Marin P, et al: Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia. Blood 93:2191-2195, 1999
26. Mathè G, Amiel JL, Schwarzenberg L, et al: Bone marrow graft in man after conditioning by antilymphocytic serum. Br Med J 2:131-136, 1970
27. McCann SR, Lawler M: Mixed chimaerism; detection and significance following BMT. Bone Marrow Transplant 11:91-94, 1993
28. McCann SR, Bacigalupo A, Gluckman E, et al: Graft rejection and second bone marrow transplants for acquired aplastic anaemia: A report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group. Bone Marrow Transplant 13:233-237, 1994
29. McGlave PB, Haake R, Miller W, et al: Therapy of severe aplastic anemia in young adults and children with allogeneic bone marrow transplantation. Blood 70:1325-1330, 1987
30. Moore MAS, Castro-Malaspina H: Immunosuppression in aplastic anemia. Postponing the inevitable? N Engl J Med 324:1358-1360, 1991
31. Paquette RL, Tebyani N, Frane M, et al: Long-term outcome of aplastic anemia in adults treated with antithymocyte globulin: Comparison with bone marrow transplantation. Blood 85:283-290, 1995
32. Passweg JR, Sociè G, Hinterberger W et al: Bone marrow transplantation for severe aplastic anemia: Has outcome improved? Blood 90:858-864, 1997
33. Rosenfeld S, Kimball J, Vming D, et al: Intensive immunosuppression with antithymocyte globulin and cyclosporin as treatment for severe aplastic anemia. Blood 85:3058-3065, 1995
34. Santos GW Owens AH Jr: Allogeneic marrow transplants in cyclophosphamide treated mice. Transplant Proc 1:44-46, 1969
35. Schrezenmeier H, Marin P, Ragavachar A, et al: Relapse of aplastic anaemia after immunosuppressive treatment: A report from the European Bone Marrow Transplantation Group SAA Working Party. Br J Haematol 85:371-377, 1993
36. Sociè G, Henry-Amar M, Cosset JM, et al: Increased incidence of solid malignant tumors after bone marrow transplantation for severe aplastic anemia. Blood 78:277-279, 1991
37. Sociè G, Amar MH, Bacigalupo A, et al: Malignancies occurring after treatment of aplastic anemia: A survey conducted by the severe aplastic anaemia Working Party of the European Group for Bone Marrow Transplantation. N Engl J Med 329:1152-1157, 1993
38. Speck B, Gluckman E, Haak HL, et al: Treatment of aplastic anemia by antilymphocyte globulin with and without allogeneic bone marrow infusion. Lancet 2:1145-1147, 1977
39. Speck B, Grathwohl A, Nissen C, et al: Treatment of severe aplastic anemia with antilymphocyte globulin or bone-marrow transplantation. Br Med J 282:860-863, 1981
40. Speck B, Tichelli A, Grathwohl A, et al: Treatment of severe aplastic anemia: A 12-year follow-up of patients after bone marrow transplantation or after therapy with antilymphocyte globulin, in Shahidi T (ed): Aplastic Anemia and Other Bone Marrow Failure Syndromes. 1990, p 96
41. Storb R, Thomas ED, Buckner CD, et al: Allogeneic marrow grafting for treatment of aplastic anemia: A follow up on long-term survivors. Blood 48:817-841, 1976
42. Storb R, Prentice RL, Thomas ED: Marrow transplantation for treatment of aplastic anemia. An analysis of factors associated with graft rejection. N Engl J Med 296:61-65, 1977
43. Storb R, Thomas ED: Marrow transplantation for treatment of aplastic anemia. Clin Haematol 7:597-609, 1978
44. Storb R, Erzioni R, Anasetti C, et al: Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia. Blood 84:941-949, 1994
45. Tichelli A, Sociè G, Henry-Amar M, et al: Effectiveness of immunosuppressive therapy in older patients with aplastic anemia. Ann Intern Med 130:193-201, 1999
46. Young N, Barrett J: The treatment of severe acquired aplastic anemia. Blood 85:3367-3377, 1998